This report describes our experience with both fine-needle aspiration (FNA) biopsies and large-needle biopsies (LNB) or core biopsies (CB) performed at the same time on 23 patients out of a series of 309 patients examined by the FNA technique. There was no significant differences in diagnostic accuracy of tissue obtained with the FNA technique when compared with the LNB or CB biopsy technique. While FNA always yielded tissue adequate for diagnosis, the LNB, and/or CB technique yielded tissue insufficient for diagnosis in four of 26 biopsies (15.4%). We believe that the FNA is better able to sample a mass with fewer insufficient specimens. Using FNA, the diagnosis can be rendered more rapidly, at lower cost, and with decreased potential for complications. The adequacy of the FNA biopsies can be assessed immediately using a modified Wright stain (Diff-Quik). Repeat biopsies can be performed that better sample the lesions with increased patient acceptance.

Adenoma↗

PubMedDate not supplied

Malignant thymic neoplasms: diagnosis by fine-needle aspiration biopsy with histologic, immunocytochemical, and ultrastructural confirmation.

Two cases of malignant thymic neoplasms diagnosed by transthoracic fine-needle aspiration (FNA) biopsy under fluoroscopic and computerized axial tomography (CT) guidance with histologic, immunocytochemical, and ultrastructural confirmation are presented. The clinical and cytomorphologic features of the first case were typical of a malignant thymoma. A characteristic biphasic cell population of benign epithelial cells and mature lymphocytes was seen in Diff-Quik- and Papanicolaou-stained smears from the anterior mediastinal mass and the paravertebral metastasis and was confirmed by histologic examination. Immunoperoxidase studies for T and B cell subsets demonstrated lymphocytes with the thymic lymphocyte phenotype (Leu 6). Electron microscopic (EM) examination revealed epithelial cells with desmosomal attachments, tonofilaments, and extended cell processes along with mature lymphocytes. FNA biopsy of the second case demonstrated features of a thymic carcinoma. Individually scattered and loosely clustered small groups of markedly anaplastic and pleomorphic large cells were seen both in the Diff-Quik- and Papanicolaou-stained smears. EM performed on the FNA specimen demonstrated the poorly differentiated epithelial nature of the malignancy. The mediastinal mass was partially resected and demonstrated an undifferentiated carcinoma staining positively for low-molecular-weight cytokeratin. Ultrastructure demonstrated cell attachments and relationships consistent with carcinoma. The lack of a lung or other extrapulmonary primary tumor was consistent with a thymic carcinoma. These cases demonstrate the value of performing EM and immunocytochemistry on material obtained by fine-needle aspiration, which can aid in establishing the correct diagnosis and facilitate the clinical management of patients with malignant thymic neoplasms.

Adult↗

PubMedDate not supplied

Goal-setting, self-efficacy, and memory performance in older and younger adults.

Research in field and laboratory settings has shown that goals lead to improved self-efficacy and performance, especially when individuals also receive positive feedback. The present study extended goal-setting theory to examine self-set goals and feedback in relation to younger and older adults' memory performance and self-efficacy. Following a baseline recall trial, participants completed three shopping list recall trials. Half of the participants were instructed to set goals for the three experimental trials, and half in each goal condition received performance feedback after each trial. Young adults' self-efficacy, clustering, and recall exceeded that of older adults. Goal setting increased self-efficacy for younger but not older adults, and it did not affect performance. Younger adults and participants in the feedback condition increased their goals across trials, as did participants for whom feedback indicated success. These data provide a first look at the motivational impact of feedback and self-set recall goals in memory aging. Additional study is needed to understand the interactive effects of type of feedback, memory task difficulty, and type of goal setting at different ages.

Adolescent↗

PubMedDate not supplied

The Short Portable Mental Status Questionnaire: assessing cognitive ability in nursing home residents.

BACKGROUND: The Short Portable Mental Status Questionnaire (SPMSQ) and other brief tests of cognitive functioning have been widely used to screen for cognitive dysfunction; however, they are rarely used to assess cognitive ability. OBJECTIVES: To discern whether the SPMSO might adequately substitute for longer assessments in the prediction of memory performance in older adults. METHOD: The SPMSQ and grocery list and prose recall tests were administered to 67 cognitively intact nursing home residents (mean age = 75 years). Demographic characteristics and self-rated health were recorded. RESULTS: The number of items missed on the SPMSQ predicted up to 32% of the variance in more extensive list and prose recall measures, even with demented patients excluded. The SPMSQ retained a strong predictive relationship to memory after age variance was removed, accounting for 11-16% of the variance. CONCLUSIONS: The SPMSQ may be useful as a general measure of cognitive abilities in nursing home residents.

Aged↗

PubMedDate not supplied

A comparison of recruiting strategies for increasing older adults' initial entry and compliance in a memory training program.

Older adults in highrise buildings were recruited for memory training using positive ("build your memory power"), neutral ("learn memory skills"), or negative ("avoid memory failures") content approaches which were: printed on a poster mounted in a prominent place (CSA), presented orally at a building meeting (PC), and, finally, printed on flyers distributed to the residents (DC). There were more volunteers after PC with neutral or positive content, but the CSA respondents were more likely to complete the training. Negative content was most likely to attract persons concerned about age-related memory decline. The discussion focused on the appropriate recruitment methods for particular intervention programs.

Aged↗