Biomedical subjects
Publications and source records attributed to R L Taylor.
This article provides an overview of assessment in the educational process and a critical analysis of the standardized tests that are typically seen in educational and psychological reports.
Approximately 10 per cent of all school-aged children have some type of learning disorder. These students are usually labeled mentally retarded, learning disabled, or emotionally disturbed/behavior disordered. The authors discuss the commonly used definitions of these disorders, the prognosis in school for children with learning disorders, the educational characteristics of these children, specific teaching and training approaches, and the administrative arrangement and physical environment for learning-disordered students.
Mice were challenged intravenously with Candida albicans, and then treated either with nothing (controls), amphotericin B-desoxycholate (AMB), or amphotericin B associated with liposomes (AMB-lipo). AMB-lipo permitted larger doses of amphotericin B to be given, and also appeared to have no severe toxicity in the animal model. High doses of AMB-lipo were protective, but at equal doses, AMB-lipo was not as effective as commercial AMB.
Increasing recognition of the importance of social support for health has not been accompanied by commensurate increases in knowledge about how to strengthen natural support networks on a large scale. This study evaluated the impact of California's innovative "Friends Can Be Good Medicine" public education campaign in promoting social support. Campaign impact was assessed with pre-, post-, and long-term follow-up interviews with a panel sample of 340 adults in the six county Fresno media market area. Comparisons of exposed and unexposed individuals found that the campaign appeared to have measurable impact on knowledge, attitudes, behavioral intentions, and support enhancing behavior. Follow-up interviews indicated that these gains maintained themselves over the course of a year. The campaign was most effective when it utilized multiple channels of communication. In Fresno City, where there was the most intensive combination of community activities and media exposure, respondents indicating substantial likelihood of engaging in support enhancing behavior increased from 42% to 59% compared to smaller gains in areas which relied primarily on community implementation, and no gains in areas where exposure to the campaign was limited to mass media. The campaign appeared particularly effective with people who had experienced the death of someone close to them during the past year, and within that group, gains were largest among respondents below average in initial levels of social support.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
The results have important heuristic value for several reasons. First, they indicate that contrary to popular belief, individuals with Prader-Willi syndrome do indicate a definite and, in fact, consistent food preference. Further, the degree of food preference seems to be related to the level of cognitive ability. Finally, these subjects consistently chose a lesser amount of preferred food over a greater amount of non-preferred food. This finding has many potential implications for contingent dietary management. These results which are contradictory to many reported observations, also indicate the importance of collecting objective data regarding the eating behaviour of this population.
Congenitally athymic (nu/nu) mice were found to be more susceptible to intravenous challenge with Sporothrix schenckii than their phenotypically normal (nu/+) littermates as measured by lethality and the number of viable yeast cells in the liver 7 days postinfection. Thymus reconstitution of nu/nu mice (nu/thy) conferred a significant degree of resistance to sporotrichosis. Immunization greatly enhanced the resistance of nu/thy and nu/+ mice, but unexpectedly increased the susceptibility of nu/nu mice. The susceptibility of nonimmunized nu/nu mice and the finding that thymus transplants augmented resistance to sporotrichosis suggest that T lymphocytes are critical to host defense.
This study was conducted to explain the lower circulating testosterone levels in chickens exposed to testosterone propionate (TP) on the 3rd day of incubation. Control and TP males were injected with either luteinizing hormone (LH) or gonadotropin-releasing hormone (GnRH). Testosterone (T), dihydrotestosterone (DHT), and LH were measured by radioimmunoassay. Levels of circulating T in 20-wk-old TP males were significantly lower than controls, but the response to GnRH was similar in both groups. LH levels were also similar. Testosterone responses to LH in 20-wk-old TP males were lower than controls, possibly due to their lower initial T concentrations. Pituitary extracts from TP and control birds showed similar abilities to induce testicular 32P uptake in day-old cockerels. The data demonstrate that the anterior pituitary gland and testes of TP birds are capable of responding to GnRH and LH, respectively. The TP males are defective in that they fail to produce testosterone, which may reflect a reduced concentration of LH receptors in their testes.
Calorie-protein deficiency affects humoral immunity in the chicken. Secondary responses to sheep-red blood cells, a T-dependent antigen, were lower in birds fed diets two-thirds deficient in calories (C), amino acids (AA), or both (C/AA). These results led us to question what effects might be found in cell-mediated immunity after nutritional deficiency. Birds fed the same diets as in our previous study showed no reduction in total white blood cells, absolute lymphocytes, or absolute heterophils. Splenic lymphocytes from 3- or 7-week-old nutritionally deficient chickens with the exception of the AA group at 7 weeks, produced a nonsignificant increase in graft-versus-host (GvH) response of 12-day-old embryos. Thymic cells from 3-week-old nutritionally deficient birds were not deficient in the GvH potential. Thymic histology revealed reduced cellularity in AA-deficient birds. The reduced cellularity may not have been in response to stress since the mean corticosterone levels were not significantly different. Birds fed the deficient diets for 10 weeks had a significantly reduced delayed hypersensitivity response to human gamma globulin. The results indicate that the chickens' ability to produce a GvH response was not compromised and that T-cell subpopulations may have differential sensitivities to nutritional deficiencies.
We have observed the rapid development (4 to 7 hr after injection) of an ascitic condition in the hepatoperitoneal sac after the i.v. injection of large amounts of carbon. The amount of ascitic fluid varied from .5 to 12 ml/chicken. The protein content of the fluid was identical with that of the sera, but the specific IgM immunoglobulin was lower in the ascitic fluid than in the sera. The cellularity of the ascitic fluid was poor. Mononuclear cells containing lipid and phagosomes and aggregated thrombocytes were the predominant cells. A mechanism regulating water balance between the liver and cecal pouch was suggested by the ascitic fluid data.
Retinas and anterior pituitary glands of nine readily available mammalian and one avian species have been examined for their TRH-sensitive binding of [3H]-[3-Me-His2]TRH. Among mammals, major species variations in TRH receptor binding have been detected in both tissues, amounting to about 100-fold in the retina and 20-fold in the pituitary. In the retina, TRH receptor binding was very high in the rat, quite high in sheep and guinea pig, intermediate in rabbit, pig, and mouse, and low but detectable in chicken, cat, calf and dog. In the pituitary gland, binding was very high in sheep, quite high in rabbit, rat, pig, calf and guinea pig, intermediate in chicken, and fairly low in mouse, cat, and dog. A number of possible interfering variables, including affinity differences, albino vs. non-albino strains, barbiturate anesthesia, time after death, sex and estrous cycle, age, and history of light exposure, were considered and/or tested directly, with generally negative results.
Liposomes were prepared to incorporate large amounts of amphotericin B. BALB/c mice were challenged with Cryptococcus neoformans and given liposome-associated amphotericin B (AMBL) or amphotericin B-deoxycholate (AMBD) intravenously. Mice that were treated with AMBL survived longer and had lower tissue counts of cryptococci than mice treated with AMBD or untreated control mice. The reduced acute toxicity of AMBL permitted much larger doses of amphotericin B to be given than were possible with AMBD. AMBL is a novel vehicle of administration that reduces toxicity and concentrates the drug in the appropriate target organs.
A survey of the regional distribution of binding of 1 nM [3H](3-Me-His2)thyrotropin-releasing hormone ([3H]MeTRH) to TRH receptors in the brains of eight mammalian species revealed major species differences in both the absolute and relative values of TRH receptor binding in different brain regions. Several brain regions exhibited binding equal to or exceeding that in the anterior pituitary gland of the same species, including the amygdala in the guinea pig and rat, the hypothalamus in the guinea pig, the nucleus accumbens in the rabbit, and all these and other regions in the cat and dog, for which pituitary binding was exceptionally low. Species could be divided into two groups according to which brain region appeared highest in binding: rabbits, sheep, and cattle had highest binding in the nucleus accumbens/septal area, whereas guinea pigs, rats, dogs, cats, and pigs had highest binding in the amygdala/temporal cortex area. The nucleus accumbens consistently exceeded the caudate-putamen in receptor binding. For most brain regions, rabbits, rodents, and sheep tended to be higher than carnivores, cattle, or pigs. Further regions that exhibited appreciable binding in most species included the olfactory bulb and tubercle, hippocampus, and various cortical and brain stem areas. In fact, essentially all brain regions appeared to have detectable levels of TRH receptors in at least some species, but no rat peripheral tissues have yet shown detectable receptor binding. The species differences appeared to reflect largely if not entirely differences in receptor density, although this was not tested in every species.
Incorporation of amphotericin B into liposomes significantly altered its toxicity, tissue distribution, and efficacy. Compared with intravenously administered amphotericin B-desoxycholate, liposome-amphotericin B showed a reduced acute toxicity and a maximal tolerable dose 9 times greater than amphotericin B-desoxycholate. Liposome-amphotericin B also produced higher tissue and lower serum concentrations than amphotericin B-desoxycholate, and was significantly more effective in prolonging survival of mice infected with Histoplasma capsulatum.
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