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Biomedical subjects

R L Stewart

Publications and source records attributed to R L Stewart.

8 recordsLinked to original sources
PubMed1986

Etiologic factors in diaper dermatitis: the role of urine.

Diaper dermatitis may result after repeated or prolonged contact of skin with urine and feces. A hairless mouse model was used to elucidate the role of urine in this process. The results of this work suggest that an important function of urine in the etiology of diaper dermatitis is to increase the pH of the diaper environment by breaking down urea in the presence of fecal urease. This rise in pH increases the activities of fecal proteases and lipases, which can damage skin. Urine can also increase the permeability of diapered skin to irritants and can directly irritate skin when exposure is prolonged.

Ammonia↗
PubMed1985

Castration method and progesterone-estradiol implant effects on growth rate of suckling calves.

Eighty male calves nursing their dams and averaging 15 d of age were used to evaluate a method of nonsurgical castration and a growth implant in a 196-d experiment. On the 1st d of the experiment, 40 calves were castrated chemically using Chem-Cast (active ingredient: lactic acid 88% wt/wt), and 40 were castrated surgically. Twenty calves on each castration treatment were implanted with STEER-oid on d 1 and reimplanted on d 121 while 20 calves on each treatment were not implanted on either date. Chemical castration resulted in significantly lower scrotal edema and a trend toward increased rate of gain at d 28. Castration treatment did not affect 196-d rate of gain and weaning weights of calves. On d 121, bilateral castration was determined in 30 of 40 chemically castrated calves, a condition that persisted on d 196, resulting in a 75% castration rate. Implanted calves had rates of gain that were 14, 6, and 4% higher, respectively, on d 28, 121, and 196 compared with unimplanted calves.

Animal Population Groups↗
PubMed1982

A prototype generalized network technology for hospitals: initial implementation.

A demonstration implementation of a distributed data-processing hospital information system using an intelligent local area communications network (LACN) technology is described. This system is operational at the UCSF Medical Center and integrates four heterogeneous, stand-alone minicomputers. The applications systems are PID/Registration, Outpatient Pharmacy, Clinical Laboratory, and Radiology/Medical Records. Functional autonomy of these systems has been maintained, and no operating system changes have been required. The LACN uses a fiber-optic communications medium and provides extensive communications protocol support within the network, based on the ISO/OSI Model. The architecture is reconfigurable and expandable. This paper describes system architectural issues, the applications environment, and the local area network.

California↗
PubMedDate not supplied

Age and diet effects on fecal bile acids in infants.

Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 months. Half were solely breast-fed and half were solely formula-fed at the beginning of the study. Breast-fed infants were found to have significantly (p less than 0.05) lower concentrations of cholic acid than the formula-fed group, up to an average age of 5 months. Concentrations of deoxycholic and lithocholic acids were directionally lower in breast-fed infants at all ages. Concentrations of chenodeoxycholic acid were similar for both groups throughout the study. At the end of the study, breast-fed infants were excreting 17% of their total bile acids in the form of secondary acids, compared to 33% for formula-fed infants. This pattern persisted long after the infants began weaning. Formula-fed infants were found to have lithocholic acid in their stools at a significantly (p less than 0.05) earlier age than breast-fed infants. Appearance of deoxycholic acid was at similar ages for both groups. Both of these secondary acids were found to occur at much younger ages (approximately 2 months) than has been previously reported. These observed differences are attributed to the distinct intestinal microbial populations encouraged by the different diets.

Aging↗