Search PubMed⌕ Search

Biomedical subjects

R L Sprott

Publications and source records attributed to R L Sprott.

At least 19 recordsLinked to original sources
PubMed1993

FRAR course on laboratory approaches to aging. Mouse and rat genotype choices.

There are advantages and disadvantages to all animal models for aging research. Investigators need to understand these issues as well as the nature of each relevant model, in order to choose the best model for their research. There is no "best" or "worst" model for aging research. Five genetically defined rodent models of potential utility in aging research are: 1. Inbred strains and F1 Hybrid mice and rats; 2. Single gene mutations and other single locus effects; 3. Congenic lines; 4. Recombinant Inbred (RI) strains; 5. Genetically selected strains and stocks. Animals of each of these types are available for research, but only inbred and F1 hybrid mice and rats are commercially available as aged animals. A general understanding of the need for careful genetic definition and for the best available barrier-breeding facilities has improved the quality of aging research significantly in the last two decades.

Aging↗
PubMed1988

Biomarkers of aging.

This article presents a conceptual discussion of some aspects involved in biomarkers of aging. A biomarker of aging is a biological parameter of an organism that either alone or in some multivariate composite will, in the absence of disease, better predict functional capability at some late age than will chronological age. The reasons for undertaking biomarker research, criteria for putative biomarkers, measurement and assessment of putative biomarkers, and the new initiative by the National Institute on Aging in biomarker research are discussed.

Aging↗