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Biomedical subjects

R L Soutar

Publications and source records attributed to R L Soutar.

28 records · Page 2Linked to original sources
PubMed1993

Parvovirus B19 induced red cell aplasia in myelofibrosis.

A 38-year-old female presented with moderate anaemia and a leucoerythroblastic blood film. Subsequent investigation showed myelofibrosis in cellular phase. Her haemoglobin quickly and spontaneously recovered with concurrent serological evidence of recent parvovirus B19 infection. This is the first report in the literature of parvovirus causing red cell aplasia in myelofibrosis.

Adult↗
PubMed1991

Dysequilibrium/ataxic diplegia with immunodeficiency.

A girl with purine nucleoside phosphorylase (PNP) deficiency is described. The nature of the motor disorder is similar to other children since found to have PNP deficiency. It is suggested that the diagnosis be considered in any child with unexplained dysequilibrium/ataxic diplegia. Other previously unreported features are intracytoplasmic neutrophil inclusion bodies and an improvement in the neutropenia after intravenous immunoglobulin.

Female↗
PubMed1990

Herniated thoracic disc mimicking spinal abscess.

Herniated thoracic discs are uncommon. Although uncommon, their potential for spinal cord damage makes them an important cause of backache. History and examination may be unhelpful, and even misleading. A diagnostic clue is disc space calcification on plain radiographs. Diagnosis can be confirmed by myelography or CT scanning. Cord compression can be prevented by surgery, which carries a low risk. Herniated thoracic disc should be remembered as a cause of backache in view of its serious, but treatable nature.

Abscess↗
PubMed1986

Interaction of tripotassium dicitrato bismuthate with macrophages in the rat and in vitro.

Tripotassium dicitrato bismuthate (TDB), De-Nol, heals peptic ulcers with an efficacy similar to the H2 antagonists. Tripotassium dicitrato bismuthate may also be effective in decreasing relapse rates. Its mode of action is unknown, but it was recently observed that TDB rapidly increased the number of macrophages in experimental ulcers. This might accelerate reparative processes, accounting for the drug's action. Using more sophisticated techniques we could not demonstrate any macrophage influx in response to single, or multiple, doses of TDB. Electron micrographs did demonstrate that monocytes, the precursors of macrophages, could internalize TDB. This process occurred rapidly in the presence of plasma where an avid TDB-protein interaction was observed. It has been suggested that such an interaction upon the ulcer may form a protective layer allowing mucosal regeneration to occur unhindered beneath. We believe our electron micrographs support this theory.

Animals↗
PubMedDate not supplied

Recent advances in the development and use of plasma concentrates.

The consequences of blood donations infected with human immunodeficiency virus, the rapid advances in protein fractionation and the introduction of recombinant DNA technology have revolutionized the range of plasma products available to the clinician. This article reviews these developments and describes recent recommendations on their use.

Blood Coagulation Factors↗