Clinical evidence for neurochemical adaptation to psychotropic drugs.
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Adaptation, Physiological↗
Biomedical subjects
R L Sack
Publications and source records attributed to R L Sack.
Inhibition of dopamine-b-hydroxylase in manic patients. A clinical trial and fusaric acid.
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Bipolar Disorder↗
Behavioral effects of a new dopamine-beta-hydroxylase inhibitor (fusaric acid) in man.
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Administration, Oral↗
Central dopamine function in affective illness: evidence from precursors, enzyme inhibitors, and studies of central dopamine turnover.
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Adult↗
Is winter depression a bipolar disorder?
Sixty-one winter depressive patients were evaluated for evidence of bipolar illness. Using the Schedule for Affective Disorders and Schizophrenia-Lifetime Version and the General Behavior Inventory, only nine (15%) could be considered bipolar. On prospective evaluation of patients during the summer following winter depression, few showed signs of manic or hypomanic symptoms. Also, few patients had a family history of bipolar illness. When patients were asked to evaluate symptoms of winter depression, lack of energy was found to be the most prominent feature of the syndrome.
Adult↗