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Biomedical subjects

R L Rudolph

Publications and source records attributed to R L Rudolph.

25 records · Page 2Linked to original sources
PubMed1978

Localization of papillomavirus and virus-specific antigens in the skin of tumor-bearing Mastomys natalensis (GRA Giessen).

In skin neoplasms (so-called keratoakanthomas, papillomas, and squamous cell carcinomas) of Mastomys natalensis (GRA Giessen) virus particles and viral antigens were demonstrated in distinct epithelial layers. Nuclei of the upper parts of the stratum granulosum and disintegrated cell parts of the stratum corneum contain viral structures. The localization of virus particles and viral antigens in any skin neoplasms of M. natalensis (GRA Giessen) corresponded to the sites where papillomavirus-specific material had been demonstrated in papillomas of other species.

Animals↗
PubMed1977

Auditory stimulus control in pigeons: Jenkins and Harrison (1960) revisited.

Pigeons were trained to peck a key in the presence of a 1000-Hz tone on a variable-interval one-minute schedule of reinforcement. One group was trained with an illuminated key; the other was trained in a totally dark chamber. During a generalization test on tonal frequency, subjects trained and tested with the key illuminated produced rather shallow gradients around the training value; subjects trained and tested in the dark produced steeper generalization gradients. These data replicate Jenkins and Harrison's (1960) finding that tone acquires relatively little control over responding and demonstrate that this absence of control is a function of the presence of the keylight.

Journal Article↗
PubMed1975

Diffuse "essential" normolipemic xanthomatosis.

Most types of cutaneous xanthomas are associated with hyperlipidemic states. However, the diffuse normolipemic xanthomatoses have normal lipid blood levels but are often associated with serious hepatic disease or hematologic dyscrasias, especially multiple myeloma. A patient is presented who had "essential" diffuse normolipemic xanthomatosis unassociated with any sytemic disease, and displayed an unusual number of different types of lesions. His condition was clearly different from those of patients reported with xanthoma disseminatum.

Adult↗
PubMed1975

Allergic contact dermatitis caused by haloprogin.

Haloprogin therapy has been used for years, but no cases of allergic contact dermatitis have been observed. On the basis of the results from several series of patch tests and biopsy findings, the first documented case, to my knowledge, of allergic contact dermatitis caused by haloprogin is reported.

Adult↗
PubMed1972

Effects of monochromatic rearing on spectral discrimination learning and the peak shift in chicks.

Chicks were hatched and raised in white or monochromatic sodium (589 nm) light. They were trained on a 590 (+) vs. 580 (-) nm successive discrimination. The combined results of two experiments indicated that rearing illumination did not affect discrimination acquisition. All subjects given generalization tests after discrimination training exhibited peak shifts that were equivalent for the two rearing conditions. The peak shifts exhibited by the monochromatically reared subjects represent maximum responding to stimuli they had not previously seen. This result further confirms the notion that behavioral control by the spectral dimension in birds is organized independently of differential early experience on that dimension.

Animals↗
PubMedDate not supplied

Effects of age and gender on venlafaxine and O-desmethylvenlafaxine pharmacokinetics.

This single- and multiple-dose, nonrandomized, inpatient study was conducted to determine the effects of age and gender on the pharmacokinetic profiles of the antidepressant venlafaxine and its equally active metabolite, O-desmethylvenlafaxine. The subjects were 18 elderly (age 60-80 yrs) and 18 young (age 21-44 yrs) subjects, 9 men and 9 women per age group. They received a single 50-mg venlafaxine dose followed by 50-mg doses every 8 hours for 5 days. No significant differences in venlafaxine single-dose pharmacokinetics were seen between age groups, but the steady-state half-life increased 24% in the elderly. For O-desmethylvenlafaxine, single doses had a significantly lower apparent clearance in the elderly (0.29 vs 0.38 L/hr/kg), longer half-life (13.2 vs 10.3 hrs), and 14% greater steady-state half-life. For the composite (venlafaxine+O-desmethylvenlafaxine), there was a nonsignificant 16% increase in elderly steady-state area under the curve (AUC* = AUC+activity factor AUCm), and AUC* was linear between doses and age groups. We conclude that venlafaxine dosage adjustments for age or gender are not necessary based on pharmacokinetics.

Adult↗