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Biomedical subjects

R L Rozental'

Publications and source records attributed to R L Rozental'.

At least 19 recordsLinked to original sources
PubMed1991

[The use of recombinant erythropoietin with patients on programmed hemodialysis].

The authors analyze the 6-month experience with the use of recombinant erythropoietin drugs to correct anemia in patients with chronic renal failure (CRF) on programmed hemodialysis. 7 patients received recormon, the mean dose was 26.0 +/- 6.0 Units/kg bw given subcutaneously thrice a week. 6 patients were given eprex, the mean dose was 34.6 +/- 4.8 Units/kg bw given intravenously three times a week. The control group was made up of 8 persons. The data obtained indicate that the use of recombinant erythropoietin in patients with CRF treated by programmed hemodialysis results in anemia elimination and appreciable improvement of the general health status, permitting blood transfusions to be avoided. Subcutaneous administration allows the use of the lower drug doses, being especially preferable in patients who are to undergo long treatment with maintenance doses.

Adult↗
PubMed1991

[Experience in treating metabolic osteopathies with 1 alpha-hydroxyvitamin D3 (oksidevit)].

The action of 1 alpha-hydroxycholecalciferol (oxydevit) was estimated in 204 patients with renal osteodystrophy, osteoporosis of varying etiology, osteomalacia because of malabsorption, congenital rickets-like diseases. The drug was shown to be highly effective in the treatment of secondary hyperparathyroidism in uremia, steroidal and senile osteoporosis. The treatment involved replacement therapy.

Bone Diseases, Metabolic↗
PubMed1990

[The diagnosis of cyclosporin nephrotoxicity in patients after kidney transplantation].

The authors review possibilities of thin needle aspiration biopsy of renal allotransplants in the diagnosis of cyclosporin nephrotoxicity. 151 thin needle aspiration biopsy specimens were explored in 55 patients following kidney transplantation. According to the authors, this method when applied in the early postoperative period may turn an informative one. However, if the time elapsed after operation exceeds 3 months, they recommend performing puncture biopsy of renal transplants.

Adolescent↗
PubMed1989

[Clinico-anatomical evaluation of donor kidneys unsuitable for transplantation].

The authors conducted clinicoanatomical analysis of 112 donor kidneys which clinicians found to be unfit for transplantation. The procedure of preparing the donors in these cases did not differ from that commonly accepted. An essential moment was prolonged arterial hypotension (6.0 +/- 0.8 hours), in donors whose kidneys were used for transplantation it lasted 2.0 +/- 0.2 hours. Examination showed that in 90% of cases the kidneys were unfit because of congenital or acquired diseases. It is concluded that the existing clinical methods for appraising the fitness of donor kidneys are adequate.

Adolescent↗
PubMed1989

[Changes in the spectra of lipoproteins and phospholipids in the blood serum of patients with chronic renal failure placed on programmed hemodialysis].

Lipid metabolism was examined over time in patients with chronic renal failure placed on programmed hemodialysis. Altogether 22 patients were examined, with the times of dialysis treatment lasting from 6 months to 3 years. In addition to routine studies of lipid metabolism, this patients' group was assessed for changes in the spectra of lipoproteins and phospholipids. It was revealed that the content of total lipids in blood serum increased because of the rise of the content of cholesterol and triglycerides, the content of low density and very low density lipoproteins and the cholesterol coefficient of atherogeneity also rose. During typing according to Friedereichson IIA, IIB and IV hyperlipidemia types were defined. During typing of normolipidemia according to T. F. Pirogova and B. L. Dundure, alpha 3A and alpha 3C normolipidemia types were identified. According to diffuse electrophoresis in polyacrylamide gel, redistribution of lipoprotein fractions towards increase of low density lipoproteins was discovered, accompanied by the reduction of the percentage of phospholipids in these fractions.

Adult↗
PubMed1987

[Means for decreasing the incidence of postoperative tubular necrosis in kidney transplants].

An analysis of the work on transplanting 264 cadaver kidneys has shown a considerable decrease of delayed functions of the transplants due to an adequate anti-ischemic defense in the donor's organism and during operation in the recipient's organism. An exact scheme of medicamentous management of the potential donors and the corresponding transfusion therapy during transplantation of the kidney has reduced the percentage of delayed functions in renal transplants from 54.4 to 25.8%.

Acute Kidney Injury↗
PubMed1986

[Renal osteodystrophy and its possible correction in patients on chronic hemodialysis].

Results of diagnosis and treatment of renal osteodystrophy are discussed concerning 162 patients with chronic renal failure treated by hemodialysis. In most cases (15%) osteopenia and hyperparathyroidism were revealed. Roentgenologic investigation revealed metastatic calcification mostly in foot vessels, whereas microscopic study of internal organs in the lungs. The increase of calcium concentration in dialysate from 1.75 to 2.5 Mmol/l was not followed by greater calcinosis in patients with hyperphosphatemia. Uremic pruritus was treated by ultraviolet irradiation and administration of prednisolone for 3-5 days. The effect of I alpha-hydroxy-vitamin D3 was studied in 30 patients. Improvement of clinical status and, principally, relief of muscular pains in the extremities was observed as well as positive changes in blood serum biochemical indices.

Adolescent↗
PubMed1984

[Treatment of gastrointestinal hemorrhage in patients following kidney transplant].

In 179 patients there were 218 operations of transplantation of the cadaveric kidney. Gastro-intestinal hemorrhages were found to develop in 16 of them (8.9%) at different terms after operations. Four patients were reoperated, 3 of them died. Twelve patients were treated by conservative methods. Eight patients survived. The transplant was functioning in 6 of them. Analysis of the material showed the conservative treatment to be the method of choice in gastrointestinal hemorrhages in the posttransplantation period. In such cases the transplant function should be given up for the sake of the patient's life. Before transplantation it is necessary to select a group of "high risk" patients. Part of them should be treated by hemodialysis only.

Adult↗
PubMed1984

[Structure of the causes of fatal outcome and functional disorder of grafts in patients following kidney transplantation].

The postmortem analysis of 146 kidney transplantations that have been performed in the Latvian centre for kidney transplantation from 1974 to 1980 is presented. The following three groups of complications as the direct causes of death are found: the complications of the immunosuppressive therapy, those of uncorrected arterial hypertension and uremic complications. These results indicate the necessity of a rational approach to the choice of immunosuppressant doses, the control and correction of the arterial pressure as well as an early programmed hemodialysis of patients with non-functioning transplanted kidneys.

Adolescent↗
PubMed1983

[Causes of removal of kidney allotransplants].

The most frequent causes of cessation of the functioning of 60 kidney transplants was an acute rejection reaction and thrombosis of main vessels of the transplanted kidney. The authors believe the attraction of the cytological analysis of the urine, instrumental and roentgen-radiological examinations as well as biochemical data to improve the diagnosis of pathological changes in the transplant.

Adolescent↗