Sulphonylurea therapy and hypothyroidism.
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Aged↗
Biomedical subjects
R L Prince
Publications and source records attributed to R L Prince.
Modulation of plasma 1,25-dihydroxyvitamin D in man by stimulation and suppression tests.
In normal volunteers infusion of parathyroid extract raised plasma 1,25-dihydroxyvitamin D (1,25-[OH]2D) levels by 80% (peak 8--40 h after infusion) without producing any significant change in plasma calcium, phosphate, or magnesium. An oral calcium load suppressed plasma 1,25-(OH)2D to 63% of control values within 48--72 h. These responses will be useful in the diagnosis and management of disturbances of calcium and mineral metabolism in which vitamin D metabolism is abnormal.
Administration, Oral↗
Evidence for an aetiological role for adenovirus type 7 in the mesenteric adenitis syndrome.
Previous research has established the relationship between viral infection with adenovirus, influenza B virus and Coxsackie B virus, and mesenteric adenitis. A prospective controlled survey of the incidence of viral infection in mesenteric adenitis was undertaken in children attending a children's hospital over a period of 13 months. Eighteen patients, together with 18 controls who were matched for age, sex, and date of presentation, were studied. There were five cases of adenovirus type 7 infection in the mesenteric adenitis group and none in the control group (P=0.023--Fisher's exact test). The clinical problem at presentation is in differentiating mesenteric adenitis from appendicitis. If further work shows that viral infection is indeed more common in mesenteric adenitis, and is limited to a narrow range of viruses, then rapid identification of these viruses in children with "acute abdomens" would be a valuable aid to differential diagnosis.
Adenoviridae Infections↗
Modelling in economic evaluation: an unavoidable fact of life.
The role of modelling in economic evaluation is explored by discussing, with examples, the uses of models. The expanded use of pragmatic clinical trials as an alternative to models is discussed. Some suggestions for good modelling practice are made.
Clinical Trials as Topic↗
The effect of estrogen on renal phosphorus handling in the rat.
BACKGROUND/AIMS: Phosphorus reabsorption in the kidney is regulated by parathyroid action on the sodium phosphorus cotransporter (Na-Pi cotransporter). There is some evidence that estrogen may also regulate renal phosphorus handling but it is not known if this is an effect of estrogen on filtered phosphorus load. METHODS: This study examined the effect of estrogen on renal phosphorus handling during infusion with calcium or EDTA. Six month old Sprague Dawley rats were bilaterally oophorectomized (OOX) or underwent a sham operation under ether anaesthesia 6 weeks before undergoing infusion with calcium chloride or EDTA. A second study examined renal phosphorus handling after estrogen replacement in the OOX rat injected with 20 microg estradiol valerate, or vehicle alone, prior to calcium infusion. RESULTS: A comparison of filtered phosphorus load with renal phosphorus excretion indicated that the estrogen replete rat had a higher renal excretion of phosphorus when infused with both calcium (p = 0.004) and EDTA (p = 0.037) at all filtered phosphorus loads. A similar analysis in calcium infused, estrogen replaced, OOX rats indicated an effect of estrogen to increase renal phosphorus excretion (p = 0.007) at all filtered phosphorus loads. OOX resulted in a mild metabolic alkalosis, an effect not reversed by estrogen administration, that was not related to renal phosphorus excretion. OOX decreased renal sodium excretion and uncoupled the relation between renal phosphorus and sodium excretion, an effect reversed by estrogen replacement. CONCLUSION: Ovarian hormone deficiency in the rat results in a decrease in renal phosphorus excretion. This finding is comparable to effects of the menopause and hormone replacement therapy in postmenopausal women.
Animals↗