The influence of atropine on the release and uptake of acetylcholine by the isolated cerebral cortex of the rat.
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Acetylcholine↗
Biomedical subjects
R L Polak
Publications and source records attributed to R L Polak.
The effect of leptazol and strychnine on the acetylcholine release from the cat brain.
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Acetylcholine↗
Effect of hyoscine on the output of acetylcholine into perfused cerebral ventricles of cats.
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Acetylcholine↗
Congenital myasthenia: end-plate acetylcholine receptors and electrophysiology in five cases.
The nature of the defect in congenital myasthenia was investigated in biopsy specimens of intercostal muscle from 5 male patients whose symptoms presented between birth and 2 years of age. Miniature end-plate potentials were reduced in amplitude in all 5 patients. The number of acetylcholine receptors as determined by alpha-bungarotoxin binding was normal in case 1 and reduced in cases, 2, 4, and 5. The shape of the end-plates as shown by autoradiography and cholinesterase staining was normal in case 1 and elongated in cases 2, 4, and 5. In cases 3, alpha-bungarotoxin binding was slowly reversible, and there were some muscle fibers with multiple end-plate regions. The acetylcholine content of the muscle was normal in all 5 cases. None of the patients had serum antibody to human acetylcholine receptor as measured by immunoprecipitation or inhibition of alpha-bungarotoxin binding. We conclude that congenital myasthenia is a heterogeneous condition of nonimmune etiology in which both presynaptic and postsynaptic defects can be found.
Acetylcholine↗