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Biomedical subjects

R L Patterson

Publications and source records attributed to R L Patterson.

At least 37 records · Page 2Linked to original sources
PubMed1975

Increasing speech intensity of chronic patients ("mumblers") bu shaping techniques.

The present experiment sought to increase the volume of speech in three adult male institutionalized patients. The method consisted of shaping modeled responses. Reinforcement was contingent upon the vocalization surpassing the threshold on an electronic volume indicator, which could be set at various levels of sensitivity. Results indicated that the volume of speech was increased in all three cases, as a function of manipulation of reinforcement contingencies. Follow-up data indicated that the long term maintenance of the acquired behavior was dependent on the ward environment.

Adult↗
PubMed1975

Rubella and rheumatoid arthritis: hyaluronic acid and susceptibility of cultured rheumatoid synovial cells to viruses.

Synovial cell lines were established from patients with rheumatoid arthritis (RA) and from normal human embryos. High levels of hyaluronic acid (HA) were produced by some RA cell lines, some of which were partially or completely resistant to infection with Newcastle disease virus (NDV), vesicular stomatitis virus (VSV), and rubella virus (RV). Normal fetal synovial cells lines were susceptible to NDV, VSV, and RV. Infection with virus became possible after treatment of RA cells with hyaluronidase to depolymerize HA, and HA prevented infection of normal synovial cells with VSV. These results provide evidence that HA and not chronic or latent viral infection is responsible for the lack of susceptibility of RA synovial cells to certain viruses.

Arthritis, Rheumatoid↗
PubMed1973

Conditioning and post-hospital generalization of nondelusional responses in a chronic psychotic patient.

An operant conditioning approach was successful in getting a chronic psychotic patient to give factual answers to direct questions that had previously elicited only delusional responses. Multiple baseline and reversal controls established that the changes were due to the experimental procedure. The subject was a female patient classified as paranoid schizophrenic who had persisted in giving bizarre responses to direct questions regarding her identity, age, and personal history during 26 yr of hospitalization. She was discharged after factual answers to these questions had been obtained, but operant conditioning trials were continued in the community to promote generalization. Two follow-up interviews were conducted 36 and 52 days after discharge to evaluate generalization. No generalization was found in the first interview, but the second gave evidence of some generalization.

Journal Article↗