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Biomedical subjects

R L Nolan

Publications and source records attributed to R L Nolan.

28 records · Page 2Linked to original sources

Immunoglobulin light chains in common acute lymphoblastic leukaemia.

A single immunoglobulin light chain lambda was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C-ALL) using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti-lambda reaction. Immunoglobulin mu chain was not identified in these patients. Results of immunoglobulin typing in 103 patients with B chronic lymphocytic leukaemia (B-CLL) are cited to show the increased sensitivity of the APAAP technique as compared to the indirect immunoperoxidase technique for cellular immunoglobulin identification.

Female↗

Castleman's disease with vascular encasement and renal sinus involvement.

Castleman's disease is a relatively rare entity. Approximately 4% of cases are located in the retroperitoneum or pelvis. The plasma cell variety accounts for 10% of all cases of Castleman's disease. A case of the plasma cell variant involving the renal sinus and retroperitoneum is presented.

Castleman Disease↗

Percutaneous endourologic approach for transitional cell carcinoma of the renal pelvis.

A small mass was detected in the renal pelvis during investigation for hypertension and diminished renal function. Its presence was confirmed by computed tomography. Since the patient was not a candidate for nephrectomy, interventional percutaneous techniques were used to confirm the diagnosis of transitional cell carcinoma and ultimately permit endourologic access for resection and cure.

Aged↗

Sonographic features of urinary bladder involvement in regional enteritis.

Three cases of regional enteritis (Crohn disease) with secondary involvement of the urinary bladder diagnosed by ultrasound are presented. The ability of ultrasound to simultaneously and noninvasively demonstrate the changes in bladder and adjacent bowel, unlike other radiologic or urologic investigations, is emphasized.

Abscess↗

Tuberculous pseudotumour of the liver developing during antituberculous chemotherapy.

A 29-year-old Chinese woman presented with a liver mass 2 months after initiation of chemotherapy for disseminated tuberculosis. A percutaneous liver biopsy revealed tuberculous pseudotumour. Although acid-fast bacilli were seen in the biopsy specimen, no organism could be cultured. No changes were made in the antituberculous chemotherapy, and the mass subsequently resolved. The patient was still well 18 months after presentation. To the authors' knowledge, the features of tuberculous pseudotumour seen with ultrasonography and computerized tomography have not previously been described, nor has this condition previously been reported in patients already receiving antituberculous chemotherapy.

Adult↗

Acetazolamide-induced nephrocalcinosis.

Nephrocalcinosis has been reported in patients treated with acetazolamide and other agents, such as furosemide or bicarbonate. We present a case of nephrocalcinosis induced solely by acetazolamide and diagnosed radiographically. Possible mechanisms of pathogenesis are reviewed.

Acetazolamide↗

Complications of hip arthroplasty simulating pelvic or bladder pathology: sonographic and radiographic findings.

BACKGROUND: The purpose of this paper was to describe the imaging features of intrapelvic complications of total hip arthroplasty. METHODS: The clinical presentation, ultrasound, and radiographic findings of three cases were reviewed. RESULTS: Intrapelvic extrusion of cement or medial migration of prosthetic hardware caused extrinsic compression of the bladder. CONCLUSION: Intrapelvic complications due to the mechanical effects of total hip arthroplasty are rare but may simulate intrinsic pelvic or bladder pathology on sonography. Plain radiographs and contrast studies provide clues to the correct diagnosis.

Aged↗

Connectivity and control in the year 2000 and beyond.

By now, most executives are familiar with the famous Year 2000 problem--and many believe that their companies have the situation well in hand. After all, it seems to be such a trivial problem--computer software that interprets "oo" to be the year 1900 instead of the year 2000. And yet armies of computer professionals have been working on it--updating code in payroll systems, distribution systems, actuarial systems, sales-tracking systems, and the like. The problem is pervasive. Not only is it in your systems, it's in your suppliers' systems, your bankers' systems, and your customers' systems. It's embedded in chips that control elevators, automated teller machines, process-control equipment, and power grids. Already, a dried-food manufacturer destroyed millions of dollars of perfectly good product when a computer counted inventory marked with an expiration date of "oo" as nearly a hundred years old. And when managers of a sewage-control plant turned the clock to January I, 2000 on a computer system they thought had been fixed, raw sewage pumped directly into the harbor. It has become apparent that there will not be enough time to find and fix all of the problems by January I, 2000. And what good will it do if your computers work but they're connected with systems that don't? That is one of the questions Harvard Business School professor Richard Nolan asks in his introduction to HBR's Perspectives on the Year 2000 issue. How will you prepare your organization to respond when things start to go wrong? Fourteen commentators offer their ideas on how senior managers should think about connectivity and control in the year 2000 and beyond.

Chronology as Topic↗