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Biomedical subjects

R L McIsaac

Publications and source records attributed to R L McIsaac.

28 records · Page 2Linked to original sources
PubMed1978

The effect of highly selective vagotomy on the relationship between gastric mucosal blood flow and acid secretion in man.

Previous work has shown that the duodenal ulcer population can be defined by a lower ratio between gastric mucosal blood flow and acid secretion (during pentagastrin stimulation) than is found in normal subjects. The results of the present investigation have shown that the ratio is restored to normality by highly selective vagotomy. This suggests that increased tonic activity of the vagus on the parietal cell is one of the important disorders in duodenal ulceration.

Adult↗
PubMed1974

Can the actions of adrenoceptor agonists and antagonists on pentagastrin-induced gastric secretion be due to their effects of histamine formation?

1 The effects of some adrenoceptor agonists and antagonists which have been reported to affect histamine formation in leucocytes (Assem & Feigenbaum, 1972) have been investigated on gastric secretion in conscious dogs with Heidenhain pouches.2 Submaximal secretion in response to pentagastrin was enhanced by propranolol (0.1-1.0 mg/kg i.v.) and phenylephrine (1.0 mug kg(-1) min(-1) i.v. for 20 min), which increase histamine formation, and was decreased by phentolamine (2 mg/kg i.v.) and isoprenaline (0.05-0.2 mug kg(-1) min(-1) i.v. for 30 min), which decrease histamine formation. Practolol (2 mg/kg i.v.), which has no effect on histamine formation, had no effect on secretion.3 Acid secretion in response to histamine was either unaffected or affected in the opposite direction by these drugs.4 The effects of the drugs on pentagastrin-induced secretion were not secondary to changes in mucosal blood flow (radioactive aniline clearance).5 The results are consistent with the hypothesis that acid secretion in response to pentagastrin involves the formation of endogenous histamine.

Animals↗