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Biomedical subjects

R L Kaplan

Publications and source records attributed to R L Kaplan.

45 records · Page 3Linked to original sources
PubMed1979

Incidence and outcome of the respiratory distress syndrome in gram-negative sepsis.

Twenty cases of the adult respiratory distress syndrome (ARDS) in 86 cases of Gram-negative bacteremia were identified. Features of Gram-negative bacteremia associated with the development of ARDS included a history of cardiac disease, hypotension, and thrombocytopenia. The mortality of patients with and without ARDS was 90% and 55%, respectively. The association of hypotension and thrombocytopenia with the subsequent development of ARDS suggests the possible role of endotoxin-induced coagulopathy in this complication.

Coronary Disease↗
PubMed1978

Progressive interstitial lung disease from prolonged methotrexate therapy.

Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years. Examination revealed a combined restrictive and obstructive defect in pulmonary mechanics and severe compromise of gas transfer across the pulmonary alveolar-capillary membrane. Improvement in the level of arterial blood gases and pulmonary diffusing capacity occurred after discontinuation of methotrexate therapy. Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.

Aged↗
PubMed1978

Neurofibromatosis and interstitial lung disease.

The literature suggests that 10% to 20% of adult patients with neurofibromatosis have associated interstitial lung disease. Characteristics of such involvement, as present in the case reported herein, include bilateral lower lobe fibrosis and may include bullous and cystic changes in advanced cases. In addition to pulmonary fibrosis, neurofibromatosis may have other intrathoracic associations; including "dumbbell" neurofibromas, intercostal neurofibromas, and intrathoracic meningoceles.

Humans↗
PubMed1976

Biochemical and biophysical properties of hyphomicrobium bacteriophage hyphi30.

Hyphomicrobium bacteriophage Hyphi30 and its nucleic acid were studied to determine some of their biochemical and biophysical properties. The molecular weight of the phage is 55.4 x 10(6), and its buoyant density is 1.508 g/ml. The nucleic acid of Hyphi30 is linear, double-stranded DNA with a molecular weight of 29.7 x 10(6). The guanine-plus-cytosine content of the DNA was 62% as determined from its melting temperature and buoyant density.

Journal Article↗
PubMedDate not supplied

Campylobacter fetus subsp. jejuni: experience in a large Chicago medical center.

From January 1979 through December 1979, 2069 stool specimens received by our laboratory for enteric culturing were additionally examined for the presence of Campylobacter fetus subsp. jejuni. The study population included inpatients, outpatients and hospital food handlers. Patients were included regardless of symptoms. Enteric pathogens were identified as follows: Salmonella, 27 isolates; Campylobacter fetus subsp. jejuni, 26 isolates; and Shigella, 11 isolates. Twenty-five of 26 patients with stool cultures positive for Campylobacter fetus subsp. jejuni had an acute diarrheal illness. Diarrhea, fever and chills were the most common symptoms. In most patients the disease was self-limited, requiring only supportive therapy. A seasonal variation was noted, with 14 of the 26 patients presenting between July and September.

Adult↗