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Biomedical subjects

R L Kahn

Publications and source records attributed to R L Kahn.

At least 37 records · Page 2Linked to original sources
PubMed1975

Memory complaint and impairment in the aged. The effect of depression and altered brain function.

To clarify the role of memory impairment in the aged as a normal or psychopathological phenomenon, 153 persons 50-years-old and over with varying degrees of depression and altered brain function were compared for their complaints about memory and actual performance on a series of memory tests. It was found that while performance varied with altered brain function, complaint was related to level of depression, regardless of performance. Exaggerated memory complaint was considered one manifestation of a general pattern of discrpant reporting of symptoms by depressed persons, and apparently related to an underlying personality factor. The complaint of superiority of remote over recent memory was not substantiated empirically, but was considered part of the pattern of stereotyped language and attitudes characteristic of depressed persons.

Age Factors↗
PubMed1975

Aging and adaptation to illness.

The relation of age, adaptation to illness, and the severity of cerebral dysfunction was evaluated for persons having suffered cerebrovascular accidents (CVA). All (89) subjects (age range 38 to 84 years, mean 62) were interviewed at least 1 mo. following onset of illness. It was found that older persons were more likely to manifest mental impairment following a DVA but that measures of sensory and motor functions were not similarly affected. The association of age and psychological adaptation varied, depending on the severity of brain dysfunction. Among a minimally impaired group, older persons tended to be more depressed and to use less denial than younger subjects. While denial was increasingly manifested by all persons with severe degrees of cerebral dysfunction, this change was shown to a greater extent by older subjects. The findings suggest that the severity of cerebral dysfunction may be a more critical factor in determining adaptation to illness than chronological age.

Adaptation, Psychological↗
PubMed1975

Molecular restriction of anti-DNP antibodies induced by (DNP)2-gramicidin S.

The molecular properties of anti-DNP antibodies were studied in 80 rabbits hyperimmunized with (DNP)2-gramicidin S. Unimmunized animals or those previously skin-painted with DNFB were subjected to biweekly injections of (DNP)2-gramicidin S. Isoelectric focusing revealed that the spectrotypes of the anti-DNP antibodies fell into three classifications; monoclonal, 18 to 21%; biclonal, 21 to 30%; and restricted, 14 to 26%. In each immunization protocol 35% of the rabbits did not respond. Longer time periods and more intensive immunization were necessary to achieve and anti-DMP response than with conventional DNP-protein conjugates, with skin painting tending to shorten the overall response time. The anti-DNP responses were invariant with respect to affinity and isoelectric spectra regardless of the immunization protocol or degree of restriction. Chain reassociation studies on antibodies purified from the sera of rabbits displaying monoclonal spectrotypes provide additional evidence that such antibodies are biosynthetically homogeneous. These data support the concept that carrier complexity influences the heterogeneity of the anti-hapten response but strongly suggests that the genetics of an outbred population may be an overriding factor in controlling response heterogeneity.

Alkylation↗