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Biomedical subjects

R L Jacobs

Publications and source records attributed to R L Jacobs.

72 records · Page 4Linked to original sources
PubMed1972

Activity of two chlorinated lincomycin analogues against chloroquine-resistant falciparum malaria in owl monkeys.

The chloroquine-resistant Oak Knoll strain of Plasmodium falciparum, recently adapted to the owl monkey (Aotus trivirgatus), was insusceptible to chloroquine therapy. Two chlorinated lincomycin analogues tested in this host-parasite system cured blood-induced infections. Acute infections were treated orally for 7 consecutive days with either 15 or 75 mg of clindamycin hydrochloride (U-21) per kg per day, 10 or 50 mg of N-demethyl-4'-pentyl clindamycin hydrochloride (U-24) per kg per day, or 20 mg of chloroquine base per kg per day. These lincomycin analogues cleared trophozoites from the peripheral blood by the end of the 7-day treatment period. The speed of clearance of parasites was not dose-related, but curative activity appeared dependent upon the amount of drug given as well as the number of daily treatments. The efficacy of U-21 and U-24 is of particular interest since they represent major structural departures from compounds commonly used in the treatment of malaria.

Animals↗
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Neuropathic spinal arthropathy. A review of the Charcot spine.

The historic, pathogenetic, and clinical aspects of neuropathic spinal arthropathy are reviewed. The disorder is characterized by biologic inflammation and repair reaction to injury. In the absence of adequate pain perception, splinting of the injured portion of the spine does not occur. Motor loss may occur. Surgical stabilization and bone grafting of the injured spine may effect correction of the kyphosis or scoliosis and permit healing of the vertebral fractures. Correction of the deformity depends on the extent of the defor pain perception, splinting of the injured portion of the spine does not occur. Motor loss may occur. Surgical stabilization and bone grafting of the injured spine may effect correction of the kyphosis or scoliosis and permit healing of the vertebral fractures. Correction of the deformity depends on extent of the deformity, the location of the lesion, and associated complicating medical disorders. A successful fusion is in no small way dependent on the desire and the ability of the patient to participate in the protracted period of postoperation care.

Adult↗
PubMedDate not supplied

Hoffman procedure in the ulcerated diabetic neuropathic foot.

Twelve diabetic patients with varying degrees of insensitivity of the foot presented with problems of forefoot ulceration beneath one or more metatarsal heads. This was associated with local abscess formation. Some of these patients had previously been subjected to surgical procedures such as ray resection or single metatarsal head resection for earlier problems and were left with areas of increased pressure in the weightbearing surface of the forefoot. Appropriate antibiotic therapy was started by the Infectious Diseases service in each case. Blood flow to the extremity was evaluated by pulse volume recordings and measurement of Doppler pressures at various levels down the extremity. Vascular reconstruction was indicated in two of these patients. After this reconstruction, circulation was deemed adequate to perform the Clayton (Clayton, M.L.: Surgery of the forefoot in Rheumatoid Arthritis. Clin. Orthop. 16:136-140, 1960) modification of the Hoffman (Hoffman, P.: An operation for severe grades of contracted or clawed toes. Am. J. Orthop. 9:441-449, 1911) procedure. This procedure was also done on 10 other patients with more adequate circulation. Although the time of healing was prolonged in some instances, all feet healed and the patients were successfully graduated to full weightbearing with extra depth shoes with soft neoprene rubber insoles. This procedure should be considered instead of transmetatarsal amputation in some patients with problems of ulceration and abscess formation of the forefoot if circulation is adequate, or can be restored to adequate levels by vascular reconstruction.

Aged↗
PubMedDate not supplied

Plantar abscess in the diabetic patient.

This is a report on 42 plantar abscesses in 40 patients with diabetes mellitus. Data concerning the mode of origin, the microorganisms involved, the antibiotics used, the end results or treatment, and the length of stay are given. Several typical cases are presented. Below-knee amputation can usually be avoided in diabetic patients with plantar abscess. The extremity can often be saved by a team consisting of specialists in infectious diseases, vascular surgery, and orthopaedic surgery.

Abscess↗
PubMedDate not supplied

Improving performance through an organizational culture of employee expertise.

Managers can do many things to improve organizational performance, but the accomplishments of the most skillful employees often are most important. This article makes the point that managers should be aware of employee expertise and its relationship to organizational performance. The article also describes the components of an organizational culture of employee expertise. An organizational culture of employee expertise builds on the learning organization metaphor that has frequently appeared in the management literature. How employees develop expertise to do their jobs is emerging as a critical issue for organizations, and managers will likely play a key role in that process.

Industry↗