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Biomedical subjects

R L Heberling

Publications and source records attributed to R L Heberling.

122 records · Page 7Linked to original sources

Serological studies of the T and tumor antigens of the oncogenic simian adenoviruses.

Tumor-specific antigens and antisera were prepared for eight of the oncogenic simian adenoviruses. Complement-fixation tests revealed three distinct serological subgroups. This grouping was maintained in studies of virus-infected cells (T antigens) although high titered preparations were obtained for only the major subgroup I. The current grouping is as follows: (I) SV1, SV11, SV25, SV33, SV34, SV38; (II) SV20, SV23; (III) SA 7. Antigens from each subgroup were rapidly inactivated at 56 C, and group II and III antigens were also markedly inactivated at 37 C. One of the tumors (SV1) also contained SV40 T antigen, suggesting origin from a simian adenovirus-SV40 "hybrid."

Adenoviridae↗

Particles morphologically resembling mouse hepatitis virus in nude mouse uterus.

Particles morphologically resembling mouse hepatitis virus were observed in uterine gland lumens and endometrial cells of 8 nude mice. Although 3 mice had been experimentally inoculated with baboon type C viral-infected materials, no ultrastructural evidence of oncornavirus-associated structures was observed.

Animals↗