Recombinant humanized antivascular endothelial growth factor (rhuMAbVEGF) is a monoclonal IgG1 antibody that is being developed as an antiangiogenic agent for use in treating a variety of solid tumors. Preclinical safety studies included an immunohistochemical tissue cross-reactivity study, in vitro hemolytic potential and blood compatibility studies, and multiple dose toxicity studies. Toxicity studies were conducted in cynomolgus monkey because rhuMAbVEGF is pharmacologically active in this species and does not bind rat or mouse vascular endothelial growth factor (VEGF). Following twice weekly administration of rhuMAbVEGF for 4 or 13 wk, young adult cynomolgus monkeys exhibited physeal dysplasia characterized by a dose-related increase in hypertrophied chondrocytes, subchondral bony plate formation, and inhibition of vascular invasion of the growth plate. In addition, decreased ovarian and uterine weights and an absence of corpora lutea were observed in females receiving 10 and 50 mg/kg/dose in the 13-wk study. Both the physeal and ovarian changes were reversible with cessation of treatment. No other treatment-related effects were observed following rhuMAbVEGF administration at doses up to 50 mg/kg. These findings indicate that VEGF is required for longitudinal bone growth and corpora lutea formation and that rhuMAbVEGF can reversibly inhibit physiologic neovascularization at these sites.

Animals↗

PubMedDate not supplied

Coalition of the hallux sesamoids: a case report.

Multiple variations in partition of the hallux sesamoids have been described; however, to our knowledge, a coalition of the hallux sesamoids has never been presented. A case of coalition of the hallux sesamoids is presented and the literature is reviewed with respect to the possible significance of this anomaly.

Adult↗

PubMedDate not supplied

A new type of dislocation of the first metatarsophalangeal joint: a case report.

We are reporting a case of traumatic dislocation of the first metatarsophalangeal joint that does not correspond to any previously reported type. This new type of dislocation was associated with a rupture of the lateral short sesamophalangeal ligament/plantar plate, partial rupture of the intersesamoid ligament, and separation of a previously bipartite tibial sesamoid. Closed reduction was easily performed; however, the distal portion of the tibial sesamoid remained trapped within the joint. The rationale for and result of surgical treatment are presented.

Adolescent↗

PubMedDate not supplied

A compromise for closed system anesthesia.

Closed system anesthesia is economical, minimally, polluting, and conserves a patient's airway heat and moisture. Yet this method of anesthesia is not widely used because it is considered dangerous by many clinicians. We review the origins of that belief and then test the application of 2 schemes for administering potent agents in a closed system with CO2 absorption. We 1st employed Lowe's square-root-of-time uptake model in 30 patients, using halothane or enflurane. We found that the model provided a good starting point for learning to use the closed system. However, anesthetic concentrations were not accurately predicted. Based on our experience with that model, we examined a simpler approach. We began each of 10 anesthetics using a semiclosed system, then closed the system. Only sufficient O2 for metabolic demand and halothane were added to the closed system. The rate of halothane administration was the same for each patient. This approach proved clinically satisfactory, and the measured halothane concentration remained relatively constant during 45 minutes using the closed system. Changing from a semiclosed to a closed system affords the advantages of the closed system 75 percent of the time, yet requires no extra tasks or equipment.

Anesthesia↗

PubMedDate not supplied

Foodborne illness: implications for the future.

Many outbreaks of foodborne illness, even those involving newly recognized pathogens, could have been avoided if certain precautions had been taken. This article will draw on existing information to suggest realistic measures that, if implemented, are most likely to avert or diminish the impact of new foodborne disease outbreaks.

Food Handling↗