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Biomedical subjects

R L Green

Publications and source records attributed to R L Green.

At least 73 records · Page 4Linked to original sources
PubMed1978

Comparative in vitro effects of imipramine, oxybutynin, and flavoxate on rabbit detrusor.

The ability of imipramine, oxybutynin, and flavoxate to antagonize carbamylcholine and barium chloride (BaCl2)-induced contractions of rabbit detrusor, and to block impulse conduction in desheathed frog sciatic nerves has been assessed in vitro. Impiramine exerts noncompetitive carbamylcholine and BaCl2 blockade by 10(-5) M and a local anesthetic effect equipotent with that of tetracaine. Oxybutynin exerts a strong competitive antagonism of carbamylcholine by 10(-8) M, a noncompetitive antagonism of BaCl2 equivalent to that of imipramine, and moderate local anesthetic activity. Flavoxate, under these experimental conditions exerts little anticholinergic, antispasmodis, or local anesthetic activity. Imipramine and oxybutynin thus demonstrate a number of smooth muscle effects by which their therapeutic actions may be exerted. The mechanisms of action of flavoxate remain obscure.

Anesthetics, Local↗
PubMed1977

Swabber's ear.

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Ear Diseases↗
PubMed1977

Paradoxical effects of calcium-glucagon interaction on cardiac muscle contractility of isolated guinea pig atria.

The interrelationships of calcium and glucagon, and calcium and Isuprel were investigated in spontaneous and paced isolated guinea pig atria. Positive force responses with glucagon were in part both frequency and [Ca+2]o-dependent. Negative inotropic responses were observed with high concentrations of glucagon (5.0 microgram/ml) and calcium (10.0 mM). Persistence of a positive inotropic response of the atria to Isuprel (1.0 microgram/ml) and high [Ca+2]o (10 mM) was seen. Catecholamines stimulate c-AMP production in guinea pig atria while glucagon may not. The negative inotropism produced via calcium-glucagon interaction is consistent with the known inhibitory action of high calcium concentration on adenylyl cyclase and stimulation of phosphodiesterase. It is hypothesized that since glucagon does not activate c-AMP in this tissue then the combined action of high calcium and glucagon leads to degeneration of contractility; with Isuprel and high calcium, atrial contractility is maintained via Isuprel's c-AMP activation.

Animals↗
PubMed1976

Increased serum immunoglobulin E concentrations in venereal diseases.

Total serum immunoglobulin E (IgE) concentrations were determined by a competitive solid phase radioimmunoassay technique in serum samples from patients with a variety of venereal diseases. The mean IgE concentrations for groups of normal persons without venereal diseases was significantly lower then the means for groups of appropriately matched patients with primary syphilis and gonorrhoea. There were also relatively higher IgE values in patients with trichomoniasis. Our data indicate that patients with urogenital infections have higher concentrations of IgE in the serum than matched control patients without such infections.

Female↗
PubMed1974

Radioimmunoassay on polycarbonate membranes: a sensitive and simplified method for the detection and quantitation of antibody.

A new radioimmunoassay technique is described in which a sampling manifold and polycarbonate filter membranes are used. Antigen-antibody reactions take place on the membranes. The manifold permits the simultaneous running of 30 samples and a rapid wash technique in which the washing solution is introduced into the manifold wells and suctioned off from below. The polycarbonate membrane offers a distinct advantage over the cellulose acetate in that nonspecific protein adsorption is substantially reduced. Antigens employed are whole bacteria or soluble antigen coupled to Sepharose beads and are layered over the membrane surface. A radiolabeled antibody is used to measure the primary antigen-antibody interaction. The sensitivity of the procedure is equal to that of fluorescent antibody tests.

Acetates↗
PubMed1972

Sickle-cell haemoglobin C disease in London.

The manifestations of the sickling disorders are becoming increasingly familiar to clinicians in Great Britain. One of these disorders, sickle-cell haemoglobin disease, has hitherto received little attention, being regarded as a relatively mild condition. This paper describes some of the distinctive clinical features of the disease as seen in a series of nine cases which have recently presented in London, two of which were fatal. The special hazards of the condition in relation to pregnancy, air travel, and general anaesthesia are discussed.

Adolescent↗
PubMed1971

The sickle-cell and altitude.

High altitude seemed to be responsible for seven recent cases of sickling crisis. People with sickle-cell trait are at risk if they fly in unpressurized aircraft, which are used for many local air services. Those with sickle-cell haemoglobin C disease should avoid air travel even in pressurized aircraft. Possibly as a result of "autosplenectomy," patients with sickle-cell anaemia seem to be able to fly in pressurized aircraft with little risk. All passengers and aircrew who might have some form of sickle-cell disease should be screened before flight.

Adolescent↗