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Biomedical subjects

R L Goode

Publications and source records attributed to R L Goode.

At least 163 records · Page 9Linked to original sources
PubMed1969

Mediastinoscopy. A valuable diagnostic aid.

Mediastinoscopy is a safe and simple endoscopic procedure for the exploration of the superior mediastinum. It provides useful information as to the possible resectability of bronchogenic carcinoma, or for establishing the diagnosis of primary tumors of the mediastinum, metastatic disease and a variety of chronic granulomata.

Adult↗
PubMedDate not supplied

Radiofrequency ablation of the nerve to the corrugator muscle for elimination of glabellar furrowing.

Glabellar furrows are caused by hyperdynamic activity of the corrugator supercilii muscles. A minimally invasive, percutaneous technique for eliminating glabellar furrows is described. An insulated, bipolar needle is inserted vertically through the eyebrow skin to entrap the corrugator nerve plexus. To confirm proper positioning, a stimulating current is delivered to the needle during observation of corrugator supercilii muscle response. Radiofrequency energy is then delivered to the needle, thereby ablating the intervening nerve tissue. This technique is in the early stage of optimization and is being evaluated in an ongoing Stanford University Human Subjects protocol, Stanford, Calif. The preliminary results are reported herein.

Cosmetic Techniques↗
PubMedDate not supplied

Efficacy of octyl-2-cyanoacrylate tissue glue in blepharoplasty. A prospective controlled study of wound-healing characteristics.

OBJECTIVE: To compare the surgical efficacy and wound-healing characteristics of the tissue adhesive octyl-2-cyanoacrylate (approved by the Food and Drug Administration) with traditional suture closure in upper blepharoplasty. METHODS: Prospective, randomized, blinded study comparing cosmetic and functional outcome and time efficiency. Twenty subjects underwent upper eyelid blepharoplasty. Each patient had a control side and an experimental side determined randomly. One eyelid incision was closed with octyl-2-cyanoacrylate (Dermabond; Ethicon Inc, Somerville, NJ) tissue glue, and the other with 6.0 suture (polypropylene or fast-absorbing gut). Comparisons were performed for the time for closure by each method, wound healing, and patient satisfaction. Macrophotographs of the wounds at 1, 2, and 4 weeks after surgery were graded by 5 observers blinded to the closure method, using a 10-point scale and a modified Hollander wound evaluation scale. RESULTS: No statistically significant difference was found between the quality of octyl-2-cyanoacrylate closure and suture closure at 1 month. There were no differences in wound complications, duration of healing, inflammation, or final incision appearance. By 2 weeks, the sides were indistinguishable in 15 (75%) of the patients. Time for closure averaged 7 minutes with suture and 8 minutes with glue. CONCLUSIONS: Octyl-2-cyanoacrylate glue is an excellent alternative to suture closure, producing equivalent quality of closure at all time points and no difference in appearance. This adhesive was sufficient to withstand the forces of closure in upper eyelid blepharoplasty without dehiscence in the absence of sutures.

Blepharoplasty↗
PubMedDate not supplied

Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase.

Type I and type II steroid 5alpha-reductases (5alpha-R) catalyze the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 is a benzoquinolinone (BQ) that inhibits 5alpha-R activity in human scalp skin (Ki(typeI)=28.7+/-1.87 nM) and prostatic homogenates (Ki(typeII)=10.6+/-4.5 nM). Lineweaver-Burk, Dixon, and non-linear analysis methods were used to evaluate the kinetics of 5alpha-R inhibition by LY320236. Non-linear modeling of experimental data evaluated V(max) in the presence or absence of LY320236. Experimental data modeled to the following equation 1v=+ fixing the In0c value equal to 1.0 or 0 are consistent with non-competitive or competitive inhibition, respectively. LY320236 is a competitive inhibitor of type I 5alpha-R (In0c=0, Ki=3.39+/-0.38, RMSE = 1.300) and a non-competitive inhibitor of type II 5alpha-R (In0c=1, Ki=29. 7+/-3.4, RMSE = 0.0592). These data are in agreement with linear transformation of the data using Lineweaver-Burk and Dixon analyses. These enzyme kinetic data support the contention that the BQ LY320236 is a potent dual inhibitor with differing modes of activity against the two known human 5alpha-reductase isozymes. LY320236 represents a class of non-steroidal 5alpha-R inhibitors with potential therapeutic utility in treating a variety of androgen dependent disorders.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMedDate not supplied

Long-term stenting in the treatment of subglottic stenosis.

Long-term stenting (3 to 12 months) with silicone rubber stents was found successful in 12 of 14 cases (86%) with severe subglottic stenosis. A new silicone rubber stent is described that is suitable for long-term stenting in infants or adults.

Adult↗
PubMedDate not supplied

Effect of mastoid cavity modification on middle ear sound transmission.

The modified radical mastoidectomy and intact canal wall mastoidectomy are the two most popular procedures used today for the treatment of chronic middle ear and mastoid disease. Their effects on the anatomy of the middle ear and mastoid cavity are quite different and it might also be expected that they would modify middle ear sound transmission in different ways. This paper describes experiments with human temporal bones and a middle ear computer analog model that attempt to define acoustic differences produced by cavity modifications in these two procedures. The temporal bone studies showed that blocking the aditus (as in modified radical mastoidectomy) produced improved sound transmission in the 1,500- to 4,000-Hz range and decreased transmission below 1,000 Hz when compared to the enlarged aditus and enlarged mastoid condition (as in intact canal wall mastoidectomy). Computer model showed better transmission at all frequencies with the intact canal wall mastoidectomy simulation.

Acoustic Stimulation↗
PubMedDate not supplied

Cis-platinum chemotherapy in head and neck cancers.

Sixteen patients with advanced head and neck carcinomas were treated with cis-diaminedichloro platinum chemotherapy; seven preoperatively and nine for recurrent disease. Cis-platinum was given by 24-hour infusions of 80 mg/m2 every three weeks. There was 50% regression in 38% (6) of the patients; another 38% (6) had 25% to 50% regression. Toxicity was minimal, with vomiting occurring in 75% (12) of the courses, renal toxicity in 6% (2), leukopenia in 13% (4), thrombocytopenia in 9% (3), and anemia in 31% (10). Of the seven patients who had serial audiograms, only one experienced ototoxicity. Cis-platinum, given by 24-hour infusion, was effective in reducing tumor bulk in 75% (12) of the patients, with advanced head and neck carcinomas, without undue morbidity.

Adult↗
PubMedDate not supplied

Frontal sinus septectomy for chronic unilateral sinusitis.

Frontal sinus trephination with removal of the intersinus septum has been found to be an effective therapy in selected cases of chronic unilateral frontal sinusitis; in addition, it may be combined with unilateral duct reconstruction in the treatment of chronic bilateral sinusitis. It may also be performed as a prophylactic measure when nasofrontal duct injury occurs during unilateral nasal or maxillary sinus surgery. The authors' experience with the procedure in 20 cases is described.

Adult↗
PubMedDate not supplied

Mandibular fracture reduction with eccentric dynamic compression plate: new treatment for an old problem.

We describe a technique and theory of application of the Eccentric Dynamic Compression Plate (EDCP) and the Dynamic Compression Plate (DCP) for mandibular fracture fixation, developed by Speissl in Switzerland, and our experience with the application of 15 plates in ten edentulous or nearly edentulous patients over the past 18 months. While we have had soft tissue infections in 4 of 15 fracture sites, our results reveal satisfactory bony healing in 14 of 15 fracture sites. We, therefore, believe that while this technique is still in the infant stages of clinical application in the United States, it has the potential to revolutionize the thinking and practice of mandibular fracture therapy.

Bone Plates↗
PubMedDate not supplied

Heat myringotomy for the treatment of serous otitis media.

A new heat myringotomy device is described that produces a 2-mm myringotomy which remains open three to four weeks without the need for a ventilation tube. The device can be used in the office in young children under iontophoretic anesthesia and may eliminate the need for tube insertion in 50% of chronic serous otitis media cases.

Child, Preschool↗
PubMedDate not supplied

Measurement of the ossicular vibration ratio in human temporal bones by use of a video measuring system.

Vibration modes of the ossicles and the lever function were studied in human cadaver temporal bones with an intact cochlea. After placing tiny steel spheres on the ossicles, ossicular vibration to a sound stimulus was measured by observing the displacements of the spheres under a microscope with strobe illumination by means of a video measuring system. The lever ratio varied from 1.9 at 0.6 kHz (minimum) to a peak of 6 near 2 kHz. This relatively high lever ratio at higher frequencies was considered to be caused by a shift of the malleus-incus rotation axis secondary to the loading of the cochlear fluid on the ossicular system. Dependence of the lever ratio on frequency indicated that the rotation axis of the ossicles was not fixed, but variable according to frequency due to a relative increase in the translational movements of the rotation axis of the malleus and incus with frequency.

Aged↗