Ileal bypass versus ileal excision: effect on cholesterol synthesis and whole blood cholesterol concentrations in the rabbit. Preliminary report.
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Animals↗
Biomedical subjects
R L Gebhard
Publications and source records attributed to R L Gebhard.
The essential role of bile in the intestinal absorption of cholesterol.
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Animals↗
Bile salts absorption following intestinal bypass.
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Adult↗
Simvastatin, a competitive inhibitor of HMG-CoA reductase, lowers cholesterol saturation index of gallbladder bile.
We tested the possibility that simvastatin, a competitive inhibitor of HMG-CoA reductase related to mevinolin, might alter cholesterol saturation of gallbladder bile. Ten patients with Type IIa or IIb hypercholesterolemia underwent bile sampling before, and again after, treatment with 20 or 40 mg per day simvastatin for 7 to 13 weeks. Mean cholesterol saturation index of gallbladder bile fell from 1.01 to 0.77 during simvastatin treatment (p less than 0.01). This finding strongly suggests that treatment with HMG-CoA reductase inhibitors will not predispose to development of cholesterol gallstones. Indeed, it raises the possibility that such inhibitors might have a future role to play in treatment of gallstones.
Adult↗