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Biomedical subjects

R L Font

Publications and source records attributed to R L Font.

256 records · Page 15Linked to original sources
PubMedDate not supplied

Correlation of computed tomographic and histopathologic features in malignant transformation of benign mixed tumor of lacrimal gland.

A 65-year-old man had painless progressive proptosis of five years' duration in his left eye. Sudden increase of the proptosis required a lateral canthotomy. A lateral orbitotomy was performed and a large, encapsulated, globoid mass was totally excised. Histopathologic diagnosis was adenoid cystic carcinoma arising in and surrounding a benign mixed tumor of the lacrimal gland. The computerized tomographic features correlated quite accurately with the gross appearance and histopathologic findings observed in the lacrimal gland mass. The authors discuss the clinical and radiographic features that should alert the clinician to the possibility of malignant transformation in a benign mixed tumor of the lacrimal gland.

Aged↗
PubMedDate not supplied

Blood staining of the cornea: a histopathologic analysis of 16 cases.

Sixteen eyes with corneal blood staining were examined by light microscopy. Two corneal buttons were also studied by electron microscopy and immunohistochemistry. By light microscopy, most eyes disclosed hyphema, angle-closure glaucoma, and endothelial attenuation with marked corneal edema. Extra- and intracellular hemoglobin particles as well as intracellular hemosiderin were found mostly in the central cornea. Frequently we observed a gradient of hemoglobin degradation from the posterior to the anterior corneal stroma with extracellular hemoglobin particles being more concentrated posteriorly while hemosiderin-laden keratocytes predominated anteriorly. By electron microscopy, moderately electron-dense, amorphous material consistent with hemoglobin was found extracellularly as well as incorporated into stromal keratocytes, while highly electron-dense, membrane-bound granules, consistent with hemosiderin, were found intracellularly. There was marked necrosis of keratocytes, mainly those that were overloaded with hemoglobin. We conclude that hemoglobin diffuses into the corneal stroma across an intact Descemet's membrane. Continuous overload with hemoglobin leads to necrosis of keratocytes and irreversible corneal blood staining.

Adult↗