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Biomedical subjects

R L Detlefs

Publications and source records attributed to R L Detlefs.

6 recordsLinked to original sources
PubMed1987

Eosinophil fluorescence: a cause of false positive slide tests for herpes simplex virus.

Two neonates who had different vesicular eruptions were erroneously diagnosed as having herpes simplex infections because of false positive results of herpes simplex fluorescent antibody slide tests. The infants, who proved to have incontinentia pigmenti and histiocytosis X, respectively, had multiple vesicular lesions containing numerous eosinophils. Eosinophils are known to show nonspecific fluorescence in immunofluorescent techniques because the fluorescein isothiocyanate label of the antiserum binds with the basic proteins in the eosinophilic granules. Clinicians should be aware that nonspecific eosinophil fluorescence may result in false positive results of immunofluorescent slide tests.

Eosinophils↗
PubMed1986

Junctional epidermolysis bullosa, pyloric atresia, and genitourinary disease.

The occasional concurrence of junctional epidermolysis bullosa and pyloric atresia has been documented in the literature. Several infants reported as having this combined disorder were also noted to have significant genitourinary disease. We treated a 4 1/2-year-old boy with mild cutaneous manifestations of junctional epidermolysis bullosa, corrected pyloric atresia, and significant renal disease secondary to recurrent obstruction of the ureterovesical junction.

Epidermolysis Bullosa↗
PubMed1986

Collagènome perforant verruciforme.

Transepidermal elimination of foreign material or altered tissue from the dermis has been reported in the literature with increasing frequency. We recently observed a rather dramatic example of transepidermal elimination of altered collagen that seemed to fit the original description of collagènome perforant verruciforme. Although described in Europe, to our knowledge, this entity has not been reported in the American literature.

Aged↗
PubMed1985

Postirradiation angiosarcoma.

A 61-year-old woman developed a cutaneous angiosarcoma of the lower abdomen in the site where she had received radiotherapy for squamous cell carcinoma of the cervix uteri 23 years earlier. The rarity of this event and the dermatologist's general unfamiliarity with this late complication of radiation therapy have prompted a review of cutaneous postirradiation angiosarcoma.

Abdomen↗