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Biomedical subjects

R Kuhn

Publications and source records attributed to R Kuhn.

At least 181 records · Page 10Linked to original sources
PubMed1979

[Heat-induced salivary gland hypertrophy: change during chronic heat exposure (34 degrees C). (author's transl)].

1 A slight rise in ambient temperature (34 degrees C) increased saliva secretion in the rat and this was accompanied by licking behavior, thus increasing heat loss by evaporation. 2 The rise in ambient temperature was accompanied by a hypertrophy of the submaxillary glands (Fig.1, 2), arising from activation of seromucous acini (Fig. 4, 5). 3 The hypertrophy reached a maximum after 2 to 4 days of heat exposure (Fig. 2); it was followed by a slow decrease. Normal values were obtained only after at least 3 weeks in the climatic chamber (Fig. 2, 3), which agreed with behavioral observations. Increased secretion of saliva may help to increase heat loss and maintain survival in a hot environment. 4 The absence of morphological changes in the sublingual g and and the evolution of the granular circonvoluted tubules (Fig. 6) contrast greatly with the hypertrophy of the submaxillary acinus. It is possible that heat-induced saliva secretion may be controlled by both sympathetic and parasympathetic systems.

Animals↗
PubMed1976

[Neuroleptic effect of baclofen in chronic schizophrenia (author's transl)].

In early 1975, surprising therapeutic effects of baclofen (Lioresal) in patients suffering from severe, chronic schizophrenia were reported from Sweden. We have carried out a study in 24 similar cases which we treated with baclofen in dosages up to 25 mg t.i.d. In rougly half of these patients no effect was observed. Of the remainder, four showed some improvement and another four a further deterioration of their condition. Those responding well were patients with acute symptoms or a history of depression, while in some of those whose condition worsened catatonic symptoms had been noted. This therapeutic possibility appears interesting from both the scientific and the practical points of view. The new class of substances merits further investigation to evaluate its psychopharmacological activity.

Aminobutyrates↗