Biomedical subjects

R Kudo

Publications and source records attributed to R Kudo.

166 records · Page 10Linked to original sources

PubMedDate not supplied

A case of carcinoma of the rectum after radiotherapy for carcinoma of the cervix.

Carcinomas are known to develop after radiation therapy for benign or malignant lesions. However, the development of primary carcinoma of the rectum following radiotherapy is relatively rare. This paper presents a case of adenocarcinoma of the rectum in which the history strongly suggested a radiation-induced carcinoma 12 years after initial radiotherapy for carcinoma of the cervix. Furthermore, it was interesting that metastatic adenocarcinoma of the skin was localized only over the pelvic and perineal area that had mild brown pigmentation from the previous irradiation. The relation between the effect of irradiation and a second primary cancer in the irradiated skin is discussed.

Abdomen↗

PubMedDate not supplied

Transmission and scanning electron microscopic study of the same cytologic material.

The same cytologic material was successively examined by light microscopy (LM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). After the SEM examination, the specimens were rehydrated for a long period of time to allow the penetration of Epon 812 into the cells. The TEM examination showed the cell organelles to be comparatively well preserved. These consecutively performed LM-SEM-TEM examinations provided useful information on cytologic subjects, especially concerning the origin of the cells.

Cell Nucleus↗

PubMedDate not supplied

Cytologic diagnosis of primary tubal cancer.

A study was made of the 128 cases of primary tubal cancer reported to date in Japan, especially of the 61 cases with a preoperative cytologic examination, which was positive for malignancy in 28 cases (45.9%). A positive cytologic diagnosis was made on the cervicovaginal smear in 37.9% of the 58 cases so examined and on the endometrial smear in 80.0% of the 15 cases so examined. Of the 12 cases with positive endocervical smear cytologies, 11 were without endometrial invasion and 4 had no cancer cells in the cervicovaginal smear. Histologic examination of endometrial curettage specimens was positive for cancer in 8 (23.5%) of 34 cases so examined. Endometrial invasion by cancer cells was seen in 11.1% of the surgically extirpated endometrial specimens. The results of this study suggest that cytologic diagnosis is one of the most reliable methods for detecting primary tubal cancer before a surgical operation is undertaken. Its efficacy might be improved by more careful sampling and study in patients suspected of having primary tubal cancer.

Endometrium↗

PubMedDate not supplied

Scanning electron microscopy of normal cells, dyskaryotic cells and malignant cells exfoliated from the uterine cervix.

The same exfoliated benign, dyskaryotic and malignant cervical cells were observed by light microscopy and scanning electron microscopy in order to investigate the reflection of the course of malignancy in the surface ultrastructure. The surface ultrastructural features (microridges and microvilli) of normal squamous cells and metaplastic cells showed regularities, with an approximately even thickness, length and distribution of microvilli. In dyskaryotic cells of the superficial type, the microridgelike structure was retained, and some regularity of the microvilli remained. However, in dyskaryotic cells of the deep-layer type, the microvillous surface ultrastructure had a pronounced irregularity and diversity. In malignant cells, there was unevenness in the projections and in the thickness of the cytoplasm, and these cells presented, as a whole, a bizarre appearance. The surface ultrastructure of malignant cells thus reflected a strong atypia of the cytoplasm.

Carcinoma in Situ↗