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Biomedical subjects

R Kropp

Publications and source records attributed to R Kropp.

At least 37 records · Page 2Linked to original sources
PubMed1981

Amezinium. Synthesis and radioactive labelling.

The synthesis of the novel pharmacologically active substance 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate (ameziniummetilsulfate, LU 1631, Regulton) and the proof of its structure are described. In addition the present paper deals with the microsynthesis of samples which are labelled at a definite site with 14C or 3H, respectively, and which are needed for the examination of its metabolism and the pharmacokinetics.

Chemical Phenomena↗
PubMed1979

[A pilot and a controlled study of the influence of ethambutol on serum urate concentration and uric acid clearance (author's transl)].

Ethambutol is said to be capable of elevating serum urate concentration. This statement was reconsidered in three investigations using strictly supervised administration of ethambutol in a single daily dose of 25 mg. per kg. of body weight: (1) In short term administration 10 healthy subjects received ethambutol for eight days. (2) In a pilot study 13 patients suffering from pulmonary tuberculosis were treated with a triple combination including thambutol for six months. (3) In a controlled trial 23 patients were randomly allocated to one of the following regiments: In the first group patients received ethambutol plus isoniazid plus rifampicin for six months. In the second group patients received streptomycin plus isoniazid plus PAS for three months and thereafter streptomycin plus isoniazid plus ethambutol for another three months. Serum urate concentrations and clearances of uric acid and of creatinine were determined periodically in all subjects. A slight increase in serum urate concentration occurring in long term therapy showed no relation to ethambutol administration, but was obviously dependant on parameters related to the course of the disease in form of increase in body weight and physical activity, or related to the well known syntropy of chronic alcoholism and tuberculosis.

Alcoholism↗
PubMed1977

[Testing of various methods for the determination of processing time for amalgam].

Four different test methods for the determination of the processing time of freshly mixed amalgam pastes were examined with the view to their utility, using 9 commercial powder alloys of different setting speeds. The tests used were a schematised stuffing test, close to the procedure used in practise, the cutting test and the compressive strength test after 10 minutes, both of which are still quoted as alternatives in the provisional standard DIN 13904, as well as a Hg addition test described by Jørgensen. The compressive strength test proved to be the quickest and most accurate. It is therefore best suited for routine examinations and general control and is recommended for inclusion in the DIN. It is necessary to set up calibration curves with the help of the stuffing test in order to estimate the processing time. These have to be separately estimated for filing amalgam and globular amalgam. The cutting test proved to be relatively inaccurate. The Hg addition test, though giving usable values, consumed too much time and material.

Dental Amalgam↗
PubMed1976

[Experiences with depot-ACTH (Tetracosactide) in bronchial obstruction].

The difficulties of long term treatment of chronic obstructive lung disease demand knowledge and use of every reasonable therapeutic regimen. In this study effectivity and side effects of Depot-ACTH (Tetracosactid) are presented. The main indications for the use of Depot-ACTH seem to be the uneffectiveness of usual therapy and the attempt of avoiding or reducing corticosteroids. The study confirms the excellent usefulness of Depot-ACTH which did not diminish during long-term application. The side effects are rare and mostly inferior. Only allergic reactions may be serious and must be accounted for.

Adolescent↗