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Biomedical subjects

R Korz

Publications and source records attributed to R Korz.

At least 19 recordsLinked to original sources
PubMed1984

[Fatty liver, metabolic acidosis and brain edema--Reye's syndrome in adults?].

Three, previously healthy, patients developed profuse vomiting. In the further course of the disease there was a marked deterioration in their general condition with massive metabolic acidosis, cerebral symptoms and, finally, deep coma which ended in death, without any evidence of poisoning. Post-mortem examination revealed diffuse, droplet fatty infiltration of the liver of the degenerative type as well as cerebral oedema without inflammatory signs, findings of Reye's syndrome, rarely seen beyond childhood. The aetiology of this prognostically unfavourable disease remains uncertain, clinical features and laboratory results are very variable. In adults the disease is rarely diagnosed because the syndrome is not known. Only liver biopsy can confirm the diagnosis. Main aim of the symptomatic treatment is to counteract the cerebral oedema.

Acidosis↗
PubMed1980

[Investigations for pathogenesis of depression of lymphocyte transformation in chronic uremia (author's transl)].

In order to investigate the depressive effect of the hypothetical low molecular weight "uremic toxins" methylguanidine and phenol on lymphocyte transformation these substances were added to lymphocyte cultures with increasing concentrations. 3H-thymidine uptake and LDH-activity in the supernatant culture medium as a parameter of continuous cell destruction were analyzed after incubation for 5 days. Both substances induced in spontaneous as well as in PHA-stimulated cultures dose-dependent depression of 3H-thymidine uptake and simultaneous increase in LDH-activity. Thus the effect of both toxins may be cytotoxic depression of lymphocyte viability. Furthermore in the same arrangement-way higher molecular weight metabolites from urine of healthy and chronic uremic persons were added in increasing concentrations to lymphocyte cultures. The same result: dose-dependent depression of transformation and increase of LDH-activity was slightly diminished by urine metabolites from uremic patients as compared to healthy persons. This may be due to a shift toward non-toxic compounds. But as these metabolites are excreted in 20-30 fold larger quantities in chronic renal insufficiency, an accumulation in the serum and classification as "uremic toxins" can be excluded.

Adult↗
PubMed1976

Biological balance of sodium and potassium: a control system with oscillating correcting variable.

The rhythm of renal sodium and potassium excretion was measured in 4-h-intervals in 12 subjects. Each person exhibited clear circadian variations of each variable with a maximum between 8 a.m. and 4 p.m. In each subject and for both circadian rhythms the oscillation mean was correlated to the range of oscillation (amplitude). Increase in sodium or potassium excretion during 1 day resulted in an increase of oscillation range. The oscillation means of sodium and potassium periodicity did not correlate. The properties of biological control systems with oscillating correcting variables are comparable to those of technical control systems. The significance of circadian rhythm for the control of electrolyte balance is indicated.

Circadian Rhythm↗
PubMed1975

[Effect of higher molecular urine metabolites on lymphocyte transformation and autohemolysis (author's transl)].

Possible toxic effects of lyophilised not dialysable residue from urine of healthy persons obtained by 4 days dialysing against water were investigated. Therefore, the substance dissolved at a concentration of 2.22 mg/ml in Medium TC 199 respectively in physiological saline solution was added with increasing quantities (0.1 to 1.0 ml) to lymphocyte cultures (3 x 10(6) cells in 4 ml medium) and to erythrocytes (3 ml of blood after separation of granulocytes) from healthy persons. Spontaneous 3H-thymidine uptake of the lymphocytes ascertained 5 days after beginning of incubation was markedly depressed with dependence upon the doses up to 30.4% of the control value, whereas only 65.2% was reached after stimulation with 400 mug PHA. In both cases LDH activity in the supernatant culture medium measured as a parameter of cell destruction showed a dose-dependent increase with inverse trend as compared to 3H-thymidine uptake levels. This negative correlation may be due to impaired cell viability as the main cause for depressed lymphocyte transformation. The autohemolysis of the erythrocytes was diminished with dependence upon the doses until to 59.3% of the control value. Therefore, only cytotoxic effects of uremic serum on the lymphocytes may be due to higher molecular urine metabolites retained in uremia whereas increased autohemolysis will be induced by toxins of lower molecular weight.

Cell Survival↗
PubMed1975

[Spontaneous lymphocyte transformation in chronic renal insufficiency (author's transl)].

3H-thymidine uptake of lymphocytes cultured from patients with regular dialysis treatment was determined at the time of maximal transformation, which was ascertained in previous investigations to be 5 days after the beginning of incubation. Spontaneous DNS synthesis was found to be significantly depressed: 1137 plus or minus 1122 c.p.m./culture; controls: 9783 plus or minus 7499 c.p.m./culture, whereas LDH activity in the supernatant culture medium measured as a parameter of continuous cell destruction showed no alteration. After stimulation with 400 mug PHA DNS synthesis in 7 patients was also decreased, but elevated in 5 patients with previous infections. After incubation with added serum from 11 chronic uremic patients, spontaneous lymphocyte transformation in cultures sampled from 2 healthy subjects was also found to be depressed with positive correlation to the hemoglobin and hematocrit levels in the corresponding blood. The significantly increased LDH activity values in the medium as the consequence of impaired cll viability showed also positive correlation with 3-H-thymidine uptake levels; therefore depressed DNS synthesis cannot be due alone to accelerated cell destruction. In analogy to the erythrocytes, two stimultaneous effects of uremic toxins in serum are assumed to be exerted on the lymphocytes: metabolic inhibition of DNS synthesis and impaired cell viability.

Blood Urea Nitrogen↗