[Acrodermatitis enteropathica].
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Biomedical subjects
Publications and source records attributed to R Kodousek.
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On the basis of electronmicroscopic study of 50 cases of plasmocytic myeloma, in part of the cases the maturational nucleoplasmic asynchrony of myelomatous plasmocytes was observed ultrastructurally. The authors discuss its importance for bioptic diagnosos.
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Basing on 13 cases of hair cell leukemia the gross morphology, histopathology and electron microscopy of this peculiar neoplasis is presented. The tricholeukocytes, as seen in Giemsa's preparation and especially in phase and electron microscope are pathognomic for establishing the diagnosis. In some cases the hairy cells may also be recognized in a HE stained tissue section. The staining method with Amidoblack 10 B may be useful for demonstrating hairy surface of the losely arranged neoplastic cells. Using a method with reduced Protargol and especially Timm's reaction after alcohol-sulfide fixation, a strong positivity could also be noticed. Exceptionaly the surface of free tricholeukocytes was found to be coated by proteinaceous precipitate resembling feature in Hoeppli's phenomen.
Report on a case of the malignant APUDOMAP (argyrophil cell carcinoma) of the uterine cervix in a 24-years old women. The tumor appeared during the third pregnancy and fatal generalization resulted cca three month after operative delivery and panhysterectomy. Histologically argyrophil cells were proved both in the primary localization and distant metastases (liver, lymph nodes, ovaries, brain, meninges, skeleton). In the electron microscope of the bioptic specimen specific granules and microfilaments were identified in some tumour cells supporting the diagnosis of a cancer of the APUD-series. Some general features of primary cervical APUDOMAS also outlined.
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