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Biomedical subjects

R Knussmann

Publications and source records attributed to R Knussmann.

21 records · Page 2Linked to original sources

Comparisons of the intra- and inter-individual variability in sex hormone levels of men.

Six blood samples were taken from each of 33 healthy young men during the course of 2 weeks. From these, the testosterone, dihydrotestosterone, and oestradiol levels were determined. In addition, free testosterone was measured using saliva samples obtained from 23 of the subjects. Both coefficients of variation and variance analyses showed that the inter-individual variability is greater than the intra-individual for all of the hormones. No influence of the day of the week could be ascertained. However, it was discovered that the serum hormone levels dropped with age (weakly significant for oestradiol, insignificant for the androgens) in spite of the subjects being in or near their third decade. The pooled intra-individual correlations between the hormones all fell within the moderate to middle-high positive domain, whereas the inter-individual correlations ranged between highly positive (testosterone to dihydrotestosterone), middle highly positive (free testosterone to total testosterone), and slightly negative (free testosterone to oestradiol).

Adult↗

Relations between anthropometric characteristics and androgen hormone levels in healthy young men.

Inter-individual correlations between androgen hormone levels and anthropometric features were computed using data from a sample of 110 healthy young men. Radioimmunoassays were used to determine the total testosterone and dihydrotestosterone in the serum and the free testosterone in the saliva. The 58 body measures encompassed the head, trunk and extremities in terms of their length, breadth and circumference. In addition, skin-fold thicknesses were also measured. This set of features was also subjected to factor analysis; the correlations of the resulting individual factor scores with the body measurements were also determined. The total testosterone and dihydrotestosterone were found to have a number of significant correlations with the various body measures and factors, while the free testosterone did not yield any significant findings. These correlations indicate in particular that there is a relation between the serum androgens and leptomorphism (especially negative correlations to indicators of the fat development), whereas a connection between the serum androgens and masculinity is only hinted at.

Adipose Tissue↗