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Biomedical subjects

R Kirchner

Publications and source records attributed to R Kirchner.

At least 73 records · Page 4Linked to original sources
PubMed1978

[Histometrical studies of liver parenchym in two cirrhotic livers (author's transl)].

Livers of two patients suffering from cirrhosis were weighed at post mortem, and found to have weights of 510 resp. 640 g. The quantity of hepatocytes was measured histometrically and estimated to be approx. 210 g in both patients; this means, that total liver mass in these patients was reduced to approximately 30% of normal, and that hepatic insufficiency had been incumbent in both of these patients. Difficulties in the methods of measuring the quantity of normal liver parenchyma in cirrhotic livers are discussed. Initiation of hepatic coma in liver cirrhosis is dependent in the first place, but not exclusively, upon the degree of reduction of liver parenchyma.

Aged↗
PubMed1978

[Metabolism of endogeneous gastrin (author's transl)].

The localization of production of gastrin is rather well known, the localization of metabolic breakdown however is still being discussed. Liver, kidneys, musculature and small intestine are being taken into consideration. Experiments were performed demonstrating a definite increase of serum gastrin after removal of the small intestine; the duodenum was not removed in these experiments, since enterogastrone is formed mainly in this organ. These results would suggest, that gastrin is metabolized in the small intestine. In order to further prove this point, truncal vagotomy was performed in rabbits, producing elevated serum gastrin levels. In other series subtotal removal of the small intestine was combined with truncal vagotomy. Serum gastrin levels were definitely higher after this latter procedure than after truncal vagotomy alone. These findings seem to support the hypothesis, that endogeneous gastrin is metabolized in the small intestine.

Animals↗
PubMed1978

[Patch widening technic of benign bile duct stenosis in dogs using teflon and Solco grafts].

In 30 dogs, weighing 20 to 30 kg, the common bile duct was ligated. Pre- and postoperative bilirubin, GOT, GPT and alc. phosphatase were controlled. Eight days later a longitudinal incision was made across the stenosed segment, which was then widened with a patch. 15 dogs received a Teflon patch - 15 other dogs a Solcograft pathch. After patch-widening-plasty laboratory parameters returned to normal within a few days. X-ray controls could not find any stenosis two years after Teflon-patch-plasty, while after Solcograft-patch-plasty four dogs showed a common bile duct-stenosis within the first following year. Four weeks after Teflon-patch-plasty the patch was covered with bile duct epithelium inside. After Solcograft-patch-plasty within the first postoperative year no epithelization could be observed.

Alanine Transaminase↗
PubMed1977

[Diagnostic value of thoracic and abdominal x-ray in acute pancreatitis (author's transl)].

Chest and abdominal films were retrospectively examined in 100 patients with acute pancreatitis excluding cases with pancreatitis concomitant to other diseases. Most frequently we found gastric and duodenal distension, diffuse distension of small bowel loops, localized meteorism of transverse colon as well as left flexure and diffuse colonic distension. The chest-films showed: elevated diaphragm and pleural effusion on the left, pneumonitis, pleuritis and and basal platelike atelectases. Pathologic radiological signs were absent in only 1% of the cases.

Acute Disease↗
PubMed1977

[Selection of procedure in the management of recurrent juvenile and aneurismatic bone cysts].

Aneurysmal and juvenile bone cysts are characterized by frequent recurrence and pathological fractures caused by such bone cysts also recur frequently. Curettage of the cyst and spongiosaplasty is often unsuccessful. According to our experience, excochleation must be followed by drilling the cyst wall and fraising off the compact substance. Densely packed homologous spongiosa must then be implanted. In case of recurrence or if the cyst increases in size, radical en-bloc resection is indicated and the defect must be bridged by osteoplastic and osteosynthetic methods. We have treated four difficult cases successfully with this procedure. In one case, resection with limb shortening lead to full recovery.

Age Factors↗
PubMed1976

[Operative treatment of massive hemorrhage from duodenal and gastric ulcers (author's transl)].

Considering the different pathogenesis of gastric and duodenal ulcers, it does not seem proper to speak of "gastroduodenal ulcer" and to postulate that bleeding gastic ulcer must be treated by resection only and the bleeding duodenal ulcer by vagotomy. Certainly our catamnestic enquiry shows that the B II gastric resection is favorable with regard to relapse and mortality rates in bleeding gastric ulcer, and the principle of vagotomy is good in bleeding duodenal ulcer; but we are of the opinion that after the introduction of controlled, selective, proximal vagotomy, only this procedure should be used for bleeding gastric and duodenal ulcers, because in this way the disadvantages of resection and the complications of truncal vagotomy can be avoided and complete intra-operative control is possible.

Adult↗
PubMed1976

Is the Gardner syndrome a separate disease? (author's transl).

A family, the members of which suffer from "Gardner's syndrome" is reported. In this family, and also in another family which is being treated in our clinic with a diagnosis of "familial polyposis of the large intestine", bronchiectasis appears with a frequency more than can be attributed to chance. Our observations suggest the following conclusions: 1. Gardner's syndrome and familial polyposis of the large intestine are diseases which cannot be strictly separated from each other, but the isolated intestinal polyposis is a monosymptomatic form of Gardner's syndrome. 2. Bronchiectasis can be considered a further symptom of this disease caused by a pleiotropic effect of a gene.

Adult↗
PubMed1976

[Roentgenologic diagnosis of splenic trauma (author's transl)].

Description of radiologic criteria in splenic trauma. Abdominal plain film: Enlarged shadow of the spleen with blurred margins; elevation - or rupture - of the left diaphragm; homogenous radiodensity in the left hypochondriac region; fractures of ribs or transverse process. Angiography is indicated in doubtful cases to clarify the following lesions: contusion, sub-or extracapsular hematoma, rupture and fragmentation. Possible diagnostic errors in arteriography (63 examined cases) are discussed.

Adult↗
PubMed1976

[Use of alloplastic material on the extrahepatic bile ducts].

Dogs (20 kg body weight) were laparotomized and the choledochous duct was ligated. Pre- and postoperative laboratory-parameters such as bilirubin, GOT, GPT, and alcaline phosphatase were controlled. Then, 8 days later, a patch-widening-plasty was performed after incision of the stenosis in 10 dogs. In the 10 other dogs the stenosis was resected and the defect was bridged over with a Teflon prosthesis. A few days later laboratory parameters became normal. Histologic investigation showed that after 4 weeks the Teflon prosthesis was covered with a bile duct-epithelial layer. In one of 3 patients with normal laboratory findings who have a Teflon patch, the operation took place 2 years ago.

Alkaline Phosphatase↗
PubMedDate not supplied

[Results following percutaneous intramedullary pin fixation in distal radius fractures].

42 distal radius fractures have been submitted to further examination after percutaneous intramedullary pin fixation. The outcome were 95.3% of very good to good anatomic results and 90.5% of satisfying functional results. This showed the close link between the radiological-anatomical and functional results. The success of the treatment was very acceptable, although the Morbus Sudeck as the major complication--with 7.2%--was still relatively frequently observed. It could be seen that particularly fractures at the risk of dislocation with smash zone constituted an indication for the percutaneous intramedullary pin fixation, that is to say all fractures for which a retention is primarily difficult. It constitutes a supplement, as well as an extension to the therapy of the distal radius fractures.

Adult↗
PubMedDate not supplied

GLP-1 release in man after lower large bowel resection or intrarectal glucose administration.

BACKGROUND: This study addresses the question whether the insulinotropic gut hormone, glucagon-like peptide-1 (GLP-1), is released from the lower large bowel upon oral or rectal glucose uptake. METHODS: It was evaluated whether rectum or sigmoid colon resection alters glucose homeostasis or the plasma levels of the insulinotropic gut hormone, gastric inhibitory polypeptide (GIP), or GLP-1. Six men and 3 women (age 63 +/- 8 years, BMI 25.4 +/- 4.0 kg/m2) with normal preoperative fasting glucose values were treated before and after resection of large bowel segments. Fasting oral glucose tolerance (OGT, 75 g glucose/300 ml) tests were performed both before and 10 days postoperatively. Another approach aimed to clarify whether luminal glucose stimulation in the rectum/sigmoid colon increases GLP-1 plasma levels. Ten healthy volunteers (4 males, 6 females, age 25 +/- 2 years, BMI 22.1 +/- 2.4 kg/m2) received enemas with both saline and, 7 days later, 1 g/kg body weight glucose (70% glucose solution) intrarectally. RESULTS: Neither rectum nor sigmoid colon resection led to significant changes in the pre- and postoperative glucose responses to OGT testing, or insulin, GIP and GLP-1 release. Intrarectal glucose instillation increased blood glucose by about 10 mg/dl with parallel small elevations in immunoreactive insulin and immunoreactive C peptide. However, plasma GLP-1 levels remained unaltered. CONCLUSION: Our data make it unlikely that GLP-1 derived from the lower large bowel contributes significantly to maintain normal glucose tolerance.

Administration, Rectal↗
PubMedDate not supplied

Management of perineal impalement injuries.

Between 1975 and 1990, 18 cases of sphincter and pelvic floor injuries, of which 7 isolated and 11 part of severe polytraumas, were treated. Thirteen cases benefited from primary repair. Colostomy was required in 9 cases due to the complexity of lesions, in other 5 cases the wounds drainage and colostomy were undertaken. Secondary repair was done after 2-6 months. The functional results in 11 patients indicate a good continence in 6 of 7 cases with primary repair. The results of secondary repair are satisfactory.

Adolescent↗