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Biomedical subjects

R Kilian

Publications and source records attributed to R Kilian.

At least 19 recordsLinked to original sources

Psychiatric services for people with severe mental illness across western Europe: what can be generalized from current knowledge about differences in provision, costs and outcomes of mental health care?

OBJECTIVE: To report recent findings regarding differences in the provision, cost and outcomes of mental health care in Europe, and to examine to what extent these studies can provide a basis for improvement of mental health services and use of findings across countries. METHOD: Findings from a number of studies describing mental health care in different European countries and comparing provision of care across countries are reported. RESULTS: The development of systems of mental health care in western Europe is characterized by a common trend towards deinstitutionalization, less in-patient treatment and improvement of community services. Variability between national mental healthcare systems is still substantial. At the individual patient level the variability of psychiatric service systems results in different patterns of service use and service costs. However, these differences are not reflected in outcome differences in a coherent way. CONCLUSION: It is conceivable that the principal targets of mental healthcare reform can be achieved along several pathways taking into account economic, political and sociocultural variation between countries. Differences between mental healthcare systems appear to affect service provision and costs. However, the impact of such differences on patient outcomes may be less marked. The empirical evidence is limited and further studies are required.

Cost Control↗

["Home treatment" for mental illness. Concept definition and effectiveness].

A number of projects have used home treatment (HT) for severely mentally ill people in recent years. This paper intends to define HT and show the main differences between it and other forms of psychiatric community service, present the existing evidence for HT, and discuss eligibility criteria. Studies about HT's efficacy in treating severely mentally ill adults were identified by electronic (MEDLINE, PsycLIT) and manual search. Six studies met these inclusion criteria. Compared to inpatient treatment, HT was equally or more efficacious in respect to reduction of symptom distress, social (re-)integration, and patient and carer satisfaction. Furthermore, direct costs for HT were often lower than for inpatient care. However, the number of relevant studies is limited and knowledge on the long-term effects of HT is sparse.

Clinical Trials as Topic↗

Natural mercury enrichment in a minerogenic fen--evaluation of sources and processes.

Mercury (Hg) records in natural archives such as peat bogs are often used to evaluate anthropogenic or climatic influences on atmospheric Hg deposition. In this context, there is an ongoing discussion about natural sources or processes of Hg enrichment in natural archives. In the present study we estimated Hg fluxes from rock weathering, direct atmospheric deposition and from indirect atmospheric deposition in the catchment of a pristine minerogenic fen (GC2) located in the Magellanic Moorlands, southernmost Chile. The Hg record in the bog covers 11 174 cal. (14)C years and shows Hg concentrations of up to 570 [micro sign]g kg(-1) with an average of 268 [micro sign]g kg(-1). Hg was found to be enriched in the peat by a factor of 81 if compared to the mean Hg concentrations in the rocks of the catchment (3.2 [micro sign]g kg(-1)). Hg and also Pb, Fe, and As were found to be enriched predominately in goethite layers indicating high retention of these elements in the bog by iron oxyhydrates. It could also be demonstrated that the high peat decomposition rates in minerogenic bogs can increase the Hg concentrations in the minerogenic peat by a factor of approximately 2 at the same atmospheric Hg deposition rate if compared to ombrotrophic sites. This study has shown that Hg in minerogenic peat can be naturally enriched especially through the retention by autochthonous formed goethite and can be a solely internal process which does not require increased external Hg fluxes.

Arsenic↗

[Methodolocical issues of naturalistic observational studies on the economic evaluation of neuroleptic treatment for schizophrenic disease].

Methodological problems of prospective natural trials are discussed. The application of adequate methods is demonstrated by analysing the effects of antipsychotic medical treatment on the probability and the costs of inpatient episodes of 307 patients with schizophrenia for 2.5 years. Selection bias is controlled by the propensity score method. Effects of medical treatment on the incidence of inpatient episodes are analysed by means of a random-effect logit model. Effects of medical treatment on the costs of inpatient episodes are analysed by means of a random-effect Tobit model. Results of the study show that antipsychotic medical treatment reduces the probability and the costs of inpatient treatment irrespective of the type of neuroleptic drugs. The hypothesis of a higher effectivity of atypical neuroleptics in comparison to conventional antipsychotics regarding the reduction of the incidence and the costs of inpatient treatment was not supported. Beyond the effects of medical treatment the study results indicate that improving social support and competence for coping with life events as well as providing community mental health services may reduce the risk and the costs of inpatient episodes.

Adolescent↗

Quality of life in persons with schizophrenia in out-patient treatment with first- or second-generation antipsychotics.

OBJECTIVE: Effects of first in comparison with second-generation antipsychotics on the subjective quality of life (QoL) of patients with schizophrenia under routine treatment conditions were examined. METHOD: In a prospective naturalistic trial the QoL, social, clinical, and treatment-related characteristics and type of antipsychotic medication of 307 patients with schizophrenia (ICD-10 F 20) were assessed five times with 6-month intervals over 2.5 years. Longitudinal and cross-sectional effects of antipsychotic medication were assessed by hierarchical regression models. Selection bias was controlled by propensity scores. RESULTS: While positive effects of first-generation antipsychotics on subjective QoL in comparison with no antipsychotic treatment were found, second-generation antipsychotics caused no better QoL than first-generation antipsychotics. CONCLUSION: The hypothesis that second-generation in comparison with first-generation antipsychotics have a better effect on the improvement of subjective QoL of people with schizophrenia in routine out-patient treatment was not supported.

Adolescent↗

[The impact of the study design and the sampling procedure on the assessment of mental health services].

In this paper the impact of the study design and the sampling procedure on the assessment of the costs of schizophrenia treatment will be analyzed. The study sample consists of 307 patients with the diagnosis of schizophrenia (ICD 10F20) with the age between 18 and 65 years. Study participants were recruited consecutively in inpatient and outpatient treatment settings and in accommodation facilities according to the proportions of patients treated in these settings in Leipzig which have been assessed before. Treatment costs have been assessed by means of the German version of the Client Sociodemographic and Service Receipt Inventory at five follow-ups at six-months intervals. For the whole study period significant differences of the mean service costs due to the recruitment setting have been found. The mean yearly costs amounted to 44.669 DM for participants recruited in sheltered accommodation, 27.975 DM for participants in inpatient treatment and 5691 DM for patients in outpatient facilities. A random-effect regression model confirmed significant effects of the recruitment setting over all five follow-ups. Additionally, the variance of costs over time indicates that cost assessment by means of cross sectional data involves the danger of errors due to random dispersion.

Activities of Daily Living↗

Effect of peat decomposition and mass loss on historic mercury records in peat bogs from patagonia.

Ombrotrophic peat bogs have been widely used to evaluate long-term records of atmospheric mercury (Hg) deposition. One of the major aims of these investigations is the estimation of the increase in atmospheric Hg fluxes during the industrial age compared to preindustrial fluxes. Comparability of Hg accumulation rates calculated from density, peat accumulation rates, and Hg concentrations requires linearity between these parameters. Peat formation is a dynamic process accompanied by intense mass loss and alteration of the organic material. Our investigations on three peat cores from the Magellanic Moorlands, Chile, indicate that Hg concentrations in peat strongly depend on peat humification. Moreover, differences in mass accumulation rates during peat evolution are not compensated by linear changes in density, peat accumulation, or Hg concentrations. We suggest that Hg accumulation rates be normalized to carbon accumulation rates to achieve comparability of Hg accumulation rates derived from differently altered peat sections. Normalization to the carbon accumulation rates reduces Hg accumulation rates in less degraded peat sections in the upper peat layers by factors of more than 2. Our results suggest that the increase in Hg deposition rates during modern times derived from ombrotrophic peat bogs are potentially overestimated if Hg accumulation rates are not corrected for mass accumulation rates.

Carbon↗

A longitudinal analysis of the impact of social and clinical characteristics on the costs of schizophrenia treatment.

OBJECTIVE: The aim of the study was the longitudinal analysis of the influence of social and clinical factors on the mid-term costs of schizophrenia treatment. METHOD: Treatment costs as well as clinical and social characteristics of 307 patients with the ICD-10 diagnosis of schizophrenia were assessed at five follow-ups over 2.5 years. Between and within effects of clinical and social characteristics on treatment costs were estimated by error component regression models. RESULTS: Effects caused by differences between individuals were found for age, partnership, in-patient history, objective and subjective role functioning, life-events and psychotic relapse. Effects of idiosyncratic transitory changes of social and clinical characteristics were found for symptoms, psychotic relapse, and for social role-functioning. CONCLUSION: Treatment costs can be reduced to a limited extent not only by the prevention of psychotic symptoms and relapse but also by the improvement of role-functioning capacities.

Adult↗

[Longitudinal analysis of factors influencing direct costs of schizophrenia treatment].

In a prospective longitudinal study with 5 points of measurement the direct service costs as well as the clinical and social characteristics of 307 outpatients with the diagnosis of schizophrenia (ICD 10 F 20.0) were assessed over a period of 2.5 years. A random-effect regression model was computed for the assessment of the impact of clinical and social variables on cost variance. Within-effect and between-effect of independent variables on the cost variance were identified by comparing of within and between effect models. Results of the study show that 10 % of the within variance and 32 % of the between variance were explained by the random effect model. Significant within effects were found for a deterioration of emotional health status and for general level of functioning. Significant between effects were found for living situation, partnership, number of inpatient episodes, psychopathological symptoms, depression, alcohol abuse and number of life events. The study results suggest that interventions aiming at the reduction of direct costs should not be restricted to medical treatment but must also include psychosocial interventions for the enhancement of general functioning. However, the explained proportions of within and between variance reveal that the possibilities of manipulating direct treatment costs by means of patient-related interventions may be limited.

Adult↗

Schizophrenic patients' subjective reasons for compliance and noncompliance with neuroleptic treatment.

Although several factors influencing schizophrenic patients' compliance with neuroleptic treatment have been investigated, the subjective reasons that patients are willing or reluctant to take medication have rarely been examined. In a follow-up study of a sample of schizophrenic patients currently undergoing psychiatric treatment in the city of Leipzig, 307 patients were asked about their subjective reasons for medication compliance or noncompliance by administering the Rating of Medication Influences (ROMI) Scale. The perceived benefit from medication proved to be the main reason for patients' compliance with neuroleptic treatment. Respectively, patient-reported noncompliance was mainly explained by negative side effects of medication. However, there were no statistically significant differences in responses between the patients receiving conventional versus second-generation antipsychotics. A positive relationship with the therapist and a positive attitude of significant others toward neuroleptic treatment contributed to patients' medication compliance. Reasons for noncompliance with neuroleptic treatment were lack of acceptance of the necessity of pharmacological treatment and lack of insight into the disease. The results emphasize the importance of psychoeducation in enhancing patient compliance with neuroleptic treatment.

Adolescent↗

Reversible fixation of carbon dioxide at nickel(0) centers: a route for large organometallic rings, dimers, and tetramers.

The reaction between bis(cycloocta-1,5-diene)nickel(0), carbon dioxide and benzaldehyde-N-furfurylideneimine (A) in 1,4-dioxane or THF results in the formation of the 24-membered organometallic macrocycles of the type [(A)Ni(-CH(R1)-N(R2)-COO-)]6(solv)n (R1: phenyl, R2: furfurylidene, solv: 1,4-dioxane in 1a, THF in 1b). According to the X-ray analyses, six monomeric nickelacyclic units are connected through six Ni-mu2-OCO-Ni bridges in these macrocycles. The cavities of the metallomacrocycles (diameter: 9.410(1) A in 1a, 9.250(1) A in 1b) each contain one solvent molecule. Reaction of 1b with Me3P results in the displacement of the peripheral ligands A by the phosphine to form the 24-membered organometallic macrocycle 1c. Both 1a and 1b isomerize in benzene to form the dimeric complex [(A)Ni(-CH(R1)-N(R2)-COO-)]2(solv)n (2). The X-ray crystal structure reveals that 2 consists of the same monomeric units as found in 1a and 1b. However two Ni-mu2-O-Ni bonds link the carboxylato groups. The solvent-dependent isomerization of 1b yielding 2 is a reversible reaction. Furthermore, the macrocycle 1b partially eliminates carbon dioxide above 20 degrees C, followed by elimination of half of the monodentately coordinated Schiff base ligands to form the planar tetrameric complex 6. This is also a reversible process.

Carbon Dioxide↗

Self-perceived social integration and the use of day centers of persons with severe and persistent schizophrenia living in the community: a qualitative analysis.

BACKGROUND: The study examined how persons with severe and persistent schizophrenia perceive their social integration and how particular types of social integration are related to the use of day centers and patient clubs. METHODS: Problem-focused interviews on self-perceived social integration and the use of day structuring services were done with 100 persons with an ICD-9 diagnosis of schizophrenia living in Leipzig. Transcribed interviews were subjected to computer-aided qualitative content analysis. RESULTS: Results of the qualitative content analysis show that the study participants can be classified in five different groups according to their self-perceived degree of social integration. The use and the subjective meaning of existing day structuring services was found to be associated with the type of self-perceived social integration. CONCLUSION: The heterogeneous ways persons with chronic schizophrenia organize their social lives lead to different kinds of needs for support. In order to meet the needs of the whole spectrum of patients this heterogeneity must be taken into account in the process of service planning.

Activities of Daily Living↗

[European standardization and German language adaptation of scales for collection of outcomes and costs of treatment for patients with severe mental disorders].

For the evaluation of the effectiveness of psychiatric service systems internationally standardised instruments for the assessment of the outcome and the costs of psychiatric and psychosocial treatment and care are increasingly needed. Beside the measurement of objective facts there is a growing importance of the consideration of the subjective perspective of patients and relatives. In the research project "Cost-effectiveness analysis of psychiatric service systems in the European comparison" of the Research association for Public Health in Saxony, developments were worked out, in close cooperation with the BIOMED-2 project "European Psychiatric Services: Inputs Linked to Outcome Domains and Needs", German versions of five European standardized instruments for the assessment of needs for care, treatment satisfaction, burden of care on relatives, quality of life and service costs. The psychometric properties of the instruments were tested within the framework of a longitudinal study with 307 patients with the diagnosis of schizophrenia. As a result of this study, German versions of all relevant European instruments for psychiatric service evaluation are now available.

Cost-Benefit Analysis↗

["(...) sometimes I have doubts about myself, when I'm not doing well". Effect of an ambulatory psychoeducational group program from the subjective perspective of patients with schizophrenic illnesses].

PURPOSE: Aim of the study is an analysis of the patients' evaluation of the impact of a psychoedukative group program for patients with schizophrenia in outpatient treatment, which was part of the project "Integrated Treatment of Schizophrenia". METHOD: Problem-focussed interviews were carried out with 30 randomly selected participants of the psychoeducative group programme. Interviews were fully transcribed and analysed by means of qualitative content analysis. RESULTS: With the exception of two persons all patients made a very positive assessment of their participation at the psychoeducative programme. The quality of the information received and the possibilities of exchanging experiences with other patients during the group sessions were mentioned by most of the participants as reasons for this positive assessment. Although only few patients reported on changes of their illness behaviour due as a result of psychoeducation, most of them underlined that that the increase of their illness-related wisdom as well as the exchange of illness experiences with other patients helped them to cope somewhat better with their illness. CONCLUSION: Psychoeducative group programmes contribute to the improvement of patients quality of life even if they have no measurable impact on illness behaviour or compliance. Hence, such group programmes should be integrated into outpatient services even if there is no evidence of a direct impact on relapse rates or cost savings.

Adult↗

["It may be somewhat more demanding sometimes, but also more interesting". Psychiatrists evaluate the impact of psychoeducation on outpatient treatment of schizophrenia].

PURPOSE: Aim of the study is the analysis of the psychiatrists' evaluation of the impact of a psychoeducative group programme on patients with schizophrenia and schizoaffective disorders, which was part of the project "Integrated Treatment of Schizophrenia". METHOD: Semi-structured interviews were carried out with 20 psychiatrists involved in outpatient treatment of patients who participated in the psychoeducative programme. Interviews were analysed by means of qualitative content analysis. RESULTS: For some patients psychiatrist noticed positive changes of the awareness for early signs of psychosis, the illness behaviour and their attitudes regarding their disorder. Although only some of the psychiatrists believe that psychoeducation has a direct impact on the reduction of relapse rates and the necessity of inpatient episodes, most of them regard the observed effects as an important improvement of the patients' ability to cope with their disorder. CONCLUSIONS: The effectiveness of psychoeducational programmes should not only be assessed by their impact on the reduction of relapse rates and health service cost but also by its contribution to the patients' quality of life. The integration of psychoeducational programmes into existing outpatient services seems to be an important task of future service planning.

Acute Disease↗

[Instruments for the economical evaluation of psychiatric service systems: methodological foundations of the European standardisation and the German adaptation].

OBJECTIVE: In the project "Cost-effectiveness of psychiatric service systems. A European comparison" a German version of instruments for the assessment of needs for services (CAN-EU), service satisfaction (VSSS-EU) relatives' burden of care (IEQ-EU) and costs of psychiatric services (CSSRI-EU) was developed in close cooperation with the EPSILON Study group. METHOD: The English original versions of the instruments were translated into German and a back-translation into the original language was carried out by a second translator. The back-translation was screened by the first author of the original version. The German versions of all instruments were tested for comprehensibility and practicability by means of focus groups. The internal consistency of all instruments were tested on a representative sample of 307 patients with schizophrenia according to ICD-10 F20. Test-retest reliability and inter-rater reliability was tested by a sub-sample of 50 patients. RESULTS: Psychometric properties of the translated instruments will be presented and discussed. CONCLUSIONS: Statistical methods for the assessment of the reliability coefficients were identical with those of the EPSILON study, therefore the psychometric properties of the German version of the CAN-EU are directly comparable with the other European versions of the instrument.

Adolescent↗

[The standardized assessment of the need for treatment and support in severe mental illness: the development and testing of the German version of the Camberwell assessment of Need-EU].

OBJECTIVE: The development and the psychometric testing of the German version of the Camberwell Assessment of Need-EU will be presented. METHOD: The internal consistency of the subscales total needs, met needs and unmet needs was tested by the application of the CAN-EU on a representative sample of 307 patients with schizophrenia according to ICD-10 F20.0. Test-retest-reliability and inter-rater-reliability was tested with a sub-sample of 41 patients. RESULTS: The internal consistency and the test-retest-reliability of the German version of the CAN-EU is satisfying and slightly higher in comparison with the other European versions. The inter-rater-reliability is also satisfying but smaller in comparison with the other European versions. CONCLUSIONS: In general, the psychometric properties of the German version of the CAN-EU are satisfying but the lower inter-rater-reliability in comparison with the other European versions suggests that more precise coding rules for the German version of the CAN-EU must be formulated to improve the inter-rater agreement of the instrument.

Adult↗

[German adaptation of the client sociodemographic and service receipt inventory - an instrument for the cost of mental health care].

AIM: Psychiatric health services research has to consider health economic points of view more than before as a result of the present-day financial problems in our health care system. Therefore an instrument was developed, which is suitable for the evaluation of cost of mental health care in Germany. METHOD: The Client Sociodemographic and Service Receipt Inventory (CSSRI-EU), which was developed in the UK, was adapted to the German situation and for the first time used in a cost-effectiveness-analysis of mental health care. The adaptation process of the instrument and the practical application are explained and pros and cons considered. RESULTS: The German adaptation of the CSSRI-EU has proven effective in practical application. The instrument offers feasible solutions for many problems with the cost of mental health care. The instrument can be used for the calculation of direct and indirect costs and gives information about service utilization and medication profiles of the clients. CONCLUSION: The German adaptation of the CSSRI-EU is a feasible instrument for the evaluation of the cost of mental health care in Germany.

Cost-Benefit Analysis↗