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Biomedical subjects

R Kikawada

Publications and source records attributed to R Kikawada.

At least 73 records · Page 4Linked to original sources
PubMed1981

A case of Fanconi syndrome with type 1 renal tubular acidosis.

A 32-year-old woman of Fanconi syndrome with disorders of amino acid, glucose, uric acid and phosphate reabsorption system in proximal tubule and of renal acid excretion mechanism in distal tubule was reported. By the ammonium chloride loading test, urinary pH could only be decreased by 5.9, and excretion rates of NH4+ and titratable acids were 18.9 and 31.1 mEq/min, respectively. In the bicarbonate loading test, net renal reabsorption of bicarbonate was 2.86 mEq/100 ml GFR when plasma bicarbonate concentration was 29 mEq/L, and threshold of bicarbonate excretion was 24-26 mEq/L. These results suggest that hydrogen ion excretion disorder in distal tubules exists, while bicarbonate reabsorption ability in proximal tubule is normal.

Acidosis, Renal Tubular↗
PubMed1978

Hemodynamic changes during hemodialysis.

35 patients with chronic renal failure were examined during the first 2 h of hemodialysis by invasive and non-invasive methods. The cardiac output was determined by the dye dilution technique in 11 of these patients and by Swan-Ganz catheterization in 5. In the patients without severe myocardial damage, the cardiac output during hemodialysis showed a significant increase (p less than 0.05), accompanied by a significant decrease of both mean blood pressure (p less than 0.05) and total peripheral resistance (p less than 0.05). Mean pulmonary artery pressure and pulmonary artery wedge pressure were reduced in all cases during hemodialysis. The increase in cardiac output during hemodialysis in patients with chronic renal failure may be attributed to the decrease in afterload.

Blood Pressure↗
PubMed1977

Clinical evaluation of myocardial contractility and its problems.

Studies were performed to assess clinical applicability and usefullness of several non-invasive indices of myocardial contractility, especially, ET/PEP, Pd/ICT and (Pd/ICT)(AO/EO). In dogs preload, afterload or myocardial contractility was altered by durgs. The ET/PEP was influenced by preload as well afterload and PdICT by afterload, respectively. A correction of Pd/ICT with preload, (Pd/ICT)/(AO/EO)showed a satisfactory correlation to Vmas even when the preload and/or afterload were altered. In clinical cases, ET/PEP, Pd/ICT and (Pd/ICT)/(AO/EO) all changed following administration of positive inotropic substances. Moreover, in azotemic cases with primary change in preload the gradient of the Frank-Sterling's curve increased progressively and the entire curve was located upwards with increase of (Pd/ICT)/(AO/EO) value. In case of high-resistance type hypertension, nevertheless, (Pd/ICT)/(AO/EO) showed a tendency to change in association with alteration of its constituent factor Pd. Since there exists no absolutely perfect non-invasive index of myocardial contractility available for clinical application as yet, it would be appropriate to make overall evaluation of myocardial contractility by combined use of several indices, with underlying pathological conditions and characteristics of individual parameters taken into consideration.

Animals↗