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R Khattech

Publications and source records attributed to R Khattech.

At least 19 recordsLinked to original sources
PubMed2000

[Adenomyoepithelioma of the breast: two cases].

Adenomyoepithelioma of the breast are very rare and form a heterogeneous tumoral group in terms of their morphology and biological behaviour. We report two adenomyoepitheliomas of the breast. One appeared in a 29-year-old woman and was a tubular adenomyoepithelioma. The patient was free of disease at a 22 months follow-up. The other was a lobular adenomyoepithelioma that appeared in a 76-year-old woman and was characterized by its high mitotic rate and its association with myoepitheliosis. Adenomyoepitheliomas of the breast are currently classified as low grade malignant tumors that may recur and rarely metastasize, but their histoprognostic factors are not yet defined.

Adult↗
PubMed1999

Chondrolipomatous tumor of the breast with myoid differentiation.

Benign human breast lesions containing chondroid tissue are uncommon. Their classification and nomenclature are confusing. We report a case of a voluminous, well circumscribed painless breast mass in a 47-year-old woman. The mass had been present for nine years and measured 17 x 8 x 6 cm. Histologically it was composed of breast parenchymal elements, fat mature cartilage and fibrous tissue with small fascicles of eosinophilic spindle-shaped cells intensely stained with actin and desmin antibodies. A careful review of the literature showed only one similar case reported by Metcalf and Ellis in 1985 and called "choristoma". We discuss this terminology and the other breast lesions containing cartilage.

Breast Neoplasms↗
PubMed1999

[Primary bone leiomyosarcoma. Anatomo-clinical, immunohistochemical, and ultrastructural study].

A variety of tissues in bone can be the origin of neoplastic primitive lesions. Consequently, it can be the site of various sarcomas of tissue type, incursing leiomyosarcoma. The leiomyosarcoma of the bone is considered as primitive after exclusion either a bony extension of a soft tissue tumor of vicinity or the presence of a leiomyosarcoma elsewhere. We report a case of a primary leiomyosarcoma arising on the left femur of a 40-year-old woman. The diagnosis was confirmed by immuno-histochemistry and electron microscopic study. A bloc resection followed by a prothesis was performed. The patient underwent a fractioned postoperative radiotherapy with a total dose of 75 Gy. The postoperative course one year later revealed local recurrence and pulmonary metastases. Despite the resection of pulmonary metastases and the amputation of left lower limb, the patient had developed local recurrence on the stump of amputated limb and was on the outside of all therapeutic resource. In this report, we present the clinicopathologic, immuno-histochemical and ultrastructural profiles of these rare primary bone tumors.

Adult↗
PubMed1996

[Primary leiomyosarcoma of the small intestine in a child].

BACKGROUND: Leiomyosarcomas of the digestive tract are very rare in children. They must be differentiated from benign tumors (leiomyoma, schwannoma...) and from other malignant tumors, sometimes with the aid of immuno-histochemical study. CASE REPORT: A five-year old girl suffered from an abdominal mass associated with fever and alteration of the general condition. An ileal tumor, 8 cm in diameter, was resected. Histological and immunohistochemical studies (anti-vimentin antibodies, anti-actin antibodies and PS100) confirmed the diagnosis of leiomyosarcoma. Uncomplete adjuvant chemotherapy failed to prevent relapse of the tumor. CONCLUSION: This case confirms the bad prognosis of such a tumor.

Child, Preschool↗
PubMed1995

Melanin production in medullary thyroid carcinoma.

A case of melanin-producing medullary thyroid carcinoma is reported in a 51-year-old man. Histologically, the tumour had a typical pattern of medullary thyroid carcinoma with numerous scattered pigmented cells which contained large amounts of melanin pigment as confirmed by bleached Fontana-Masson stain. Immunohistochemical staining revealed positivity of almost all tumour cells for calcitonin and chromogranin, whereas S-100 protein and HMB-45 staining was positive only in the pigmented tumour cells. This finding confirms the ability of medullary thyroid carcinoma cells to have multidirectional differentiation, although melanocytic differentiation remains an exceptional phenomenon.

Amyloid↗
PubMed1995

[Microcystic adenoma of the pancreas].

Microcyst adenomas of the pancreas are rare tumours with characteristic cysts lining the cubic and cylindric epithelia with a clear cytoplasm rich in glycogen. Unlike, mucinous cyst adenomas, there is no tendency toward malignancy. We report a case in a 58-year-old woman and emphasize the importance of precise pre- or per-operative diagnosis in order to avoid excessive exeresis for benign tumour. Certain authors propose abstention and follow up.

Cystadenoma, Serous↗
PubMed1995

[Breast myoepithelioma. Report of a case].

Myoepithelial cell tumors of the breast are rare. They present diagnostic difficulties not only on frozen sections but also after fixation and paraffin embedding. These tumors can give rise to a wide range of clinical evolution... Treatment vary from simple excision for myoepitheliosis to mastectomy with axillary node dissection for malignant myoepitheliomas. Large excision is necessary for adenomyoepitheliomas because of the risk of recurrence and, more uncommonly, their proclivity to metastasis. We report the case of breast myoepithelioma in a 42 years old woman. The tumor was clinically, radiologically and macroscopically well demarcated. Histologically the tumor was composed of myoepithelial cells with few cellular atypias and a low mitotic activity. Tumor cells expressed vimentin, actin, S100 protein and cytokeratin. This particular immunohistochemical phenotype allows the differential diagnosis with other breast tumors.

Adult↗
PubMed1995

[Ovarian hydatic cyst. 7 cases].

Seven cases with echinococcal infection of the ovary, including 3 on both sides, were collected at the Salah Azaiz Institute of Tunis during a period of 23 years. This localisation is rare, even in an endemic country. The aetiology and pathogenesis of this affection may give rise to many different clinical signs, problems with pre-operative diagnosis. It is important to follow up these cases after operation in order to sport recurrences. The objective of surgical treatment is to achieve cure of both the hydatic cyst of the ovary and the primitive cyst simultaneously. Following this treatment, two difficulties may arise: the first one is preoperative rupture of the cyst; the second concerns fertility in these young women after two-sided salpingo-oophorectomy. Finally, when a pelvic cyst is observed systematic hydatic serology must be performed.

Adult↗
PubMed1995

[Breast angiosarcoma. Five case reports].

The authors report 5 cases of breast angiosarcoma collected in the Salah Azaiz Institute of Tunis, the only oncology center in this country, between 1969 and 1990. They enumerated 4,000 malignant breast tumors during this period; i.e. an incidence of 1.25%, higher than that in the world literature (0.4%). The mean age of patients was 44. Three were post-menopausal, and two were of childbearing age, one of whom was pregnant. This rare tumor is virtually limited to women. Affection is scarce, it affect's almost exclusively women. It generally present as a painless, ill-defined mass, without regional lymphadenopathy. The diagnosis of angiosarcoma is difficult since the histologic appearance is sometimes identical to that of a hemangioma. Hence the value of very thorough histologic examination of the entire operative specimen. Treatment is based upon mastectomy. The usefulness of adjuvant chemotherapy and/or radiotherapy is uncertain. The prognosis remains gloomy despite early diagnosis and treatment. The authors attempt in this study to identify the various features of this serious and uncommon condition, based upon the rare published cases in the world literature.

Adult↗
PubMed1994

[Granular cell tumors of the breast. Apropos of two cases].

Granular cell tumors of the breast are rare. The clinical presentation, the poor macroscopical delimitation and the infiltrating appearance of the tumor cells between the mammary lobules and within the adipose tissue may lead to a diagnosis of carcinoma, especially on frozen section. The authors present two cases of granular cell tumor of the breast occurring in two women aged 19 and 59 respectively. Before surgery, the diagnosis was that of a malignant tumor. In both cases, frozen section suggested the diagnosis of a granular cell tumor, which was confirmed by immunohistochemical study in one patient.

Adult↗
PubMed1994

[Tumoral calcinosis: a clinical and pathological study of 8 cases reported in Tunisia].

Tumoral calcinosis is a distinct clinicopathological entity characterized by periarticular soft-tissue calcium deposits. It is a rare condition in Tunisia (8 cases during 23 years). Six patients were aged 14 years or younger. There was male predominance (SR: 7/1). Lesions were located about the hip in five patients and the elbow in three patients. Multiple localisations occurred in two patients. Histologically, all cases exhibited active phase of the disease. In our patients lesions were only surgically excised.

Calcinosis↗