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Biomedical subjects

R Khardori

Publications and source records attributed to R Khardori.

At least 37 records · Page 2Linked to original sources
PubMed1992

Gene therapy: a status report.

Gene therapy is a way to treat disease by transfer of genetic material into the cells of a diseased organism. Generally it is transferred in the form of one or few genes. There is a tremendous potential for application of this technique to the treatment of human hereditary diseases, particularly single gene disorders. Due to ethical and practical reasons, it is currently being used only as somatic cell therapy but it could be achieved by germline also. The major problem in gene therapy is achieving an efficient gene transfer and a persistent gene expression in appropriate somatic cells.

Animals↗
PubMed1991

Lymphocytic interstitial pneumonitis in autoimmune thyroid disease.

Four patients are described who were found to have autoimmune thyroid disease associated with lymphocytic interstitial pneumonitis. The patients were not receiving any medications known to cause lymphocytic interstitial pneumonitis. Their response to steroid therapy and the relapse of their clinical symptoms after steroid withdrawal support an underlying immunologic dysfunction. It is proposed that lymphocytic interstitial pneumonitis may be yet another manifestation of immune dysfunction in autoimmune thyroid disease.

Adult↗
PubMed1990

Usefulness of MC-540 fluorescent dye as probe versus scanning electron microscopy for assessing membrane changes.

The effect of primaquine enantiomers on cell membranes of glucose-6-phosphate (G-6PD)-deficient erythrocytes was studied in vitro. Staining with merocyanine (Mc-540) showed that exposure to primaquine enantiomers produces significant fluorescence in G-6PD-deficient erythrocytes, indicating marked drug-induced alterations in membrane fluidity. Scanning electron microscopy (SEM) studies confirmed that primaquine enantiomers altered membrane morphology (by producing stomatocytes) in both normal and G-6PD-deficient cells. The concentration-dependent effect, however, was more pronounced with MC-540, a lipophylic dye, than with SEM (an expensive technique).

Erythrocyte Membrane↗
PubMed1987

A mathematical model for insulin kinetics and its application to protein-deficient (malnutrition-related) diabetes mellitus (PDDM).

A nonlinear mathematical model which incorporates both beta-cell kinetics and a glucose-insulin feedback system is proposed for describing the time variations of plasma glucose and insulin levels. Numerical simulations show that this model is consistent with experimental observations on normal groups. An analysis of the changes in the solutions with variations in the parameters showed that a decrease in a single parameter gave results consistent with experimental findings in protein-deficient (malnutrition-related) diabetes mellitus (PDDM). The model predicts that it is the function and not the number of beta cells which is reduced in PDDM.

Blood Glucose↗
PubMed1987

Cardiac bypass surgery with haemorrhagic endocrine sequelae.

Cardiac bypass surgery is associated with changes in haemostatis which can lead to bleeding. This report highlights two examples of such bleeding which led to unusual clinical presentations and endocrinological consequences: adrenal and pituitary haemorrhage.

Adrenal Gland Diseases↗
PubMed1987

Growth hormone responses in isolated protein deficiency state in rhesus monkey.

We have longitudinally studied the effects of protein-deficient diet on serum growth hormone (GH) concentration in rhesus monkey. A biphasic basal GH response and a phenomenon of failure to suppress GH levels after glucose administration were observed in animals fed diet lacking proteins. GH levels remained consistently elevated in protein-deprived monkeys. Whether these elevations in GH will have any deleterious influence on the host remains to be seen.

Animals↗
PubMed1986

Brainstem auditory and visual evoked potentials in type 1 (insulin-dependent) diabetic patients.

Brainstem auditory evoked potentials and pattern shift visual evoked potentials were measured in 34 Type 1 (insulin-dependent) diabetic patients with long-standing disease and in 43 control subjects. Thirty-two percent of diabetic patients had abnormal brainstem auditory evoked potentials and 15% had abnormal visual evoked potentials. These abnormalities were not related to duration of diabetes, diabetic control or individual diabetic complications (retinopathy, nephropathy, peripheral or autonomic neuropathy). The aetiology of the abnormalities must remain a subject for speculation. The findings of this study are consistent with a central diabetic neuropathy involving the brainstem in long-standing diabetic patients.

Adolescent↗
PubMed1985

Electrocardiographic finding simulating acute myocardial infarction in a compound metabolic aberration.

A patient with hypokalemic metabolic alkalosis, hypophosphatemia, and hypomagnesemia/hypocalcemia is described. Electrocardiography demonstrated the pattern of acute anterior myocardial infarction. Further evaluation revealed that the patient had not actually had the acute myocardial infarction and that the electrocardiographic change was a mere simulation. The possible role of hypomagnesemia in the pathogenesis of the electrocardiographic change and the interrelation between the metabolic disturbances noted are discussed.

Alkalosis↗
PubMed1984

Fibrous disease of the breast, thyroiditis, and cheiroarthropathy in type I diabetes mellitus.

Fibrous breast lumps were noted in 12 women with longstanding type I diabetes mellitus who had multiple diabetic complications including cheiroarthropathy (11 of 12). 5 of the 12 women also had thyroid microsomal antibodies (greater than 1:1000). The coexistence of cheiroarthropathy and fibrosis of the breasts raises the possibility of a common link related to the connective-tissue abnormalities observed in diabetes. Although autoimmunity may also be a factor, HLA histocompatibility typing did not indicate that these patients formed a distinct subgroup of type I diabetics.

Adult↗
PubMed1984

Graves' ophthalmopathy. An unusual course.

A patient with an unusual course of Graves' ophthalmopathy is presented; serial computed tomographic scanning of the orbits was used to follow the course of the eye disease. Right-sided unilateral ophthalmopathy first developed two years after thyroid ablation with radioactive iodine and was followed by complete resolution two years later. The remission of this patient's eye disease was short-lived; within eight months, unilateral ophthalmopathy affected the left eye, and ophthalmopathy recurred in the right eye a few months later. Current hypotheses do not readily explain the course of this patient's ophthalmopathy.

Female↗
PubMed1984

Hyperosmolar hyperglycemic nonketotic syndrome. Report of 22 cases and brief review.

In a series of 22 patients with the hyperosmolar hyperglycemic nonketotic syndrome managed during a five-year period in a community hospital setting, 21 patients were known to be diabetic and only six patients were in coma. The overall mortality was 36.3 percent, and seven of the eight deaths were explained by associated nonmetabolic causes. In this study, hyperosmolarity was not related to coma or to final outcome of treatment. Patients were managed with relatively small amounts of fluid, and the type of fluid used did not influence the final outcome.

Adult↗