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Biomedical subjects

R Kelly

Publications and source records attributed to R Kelly.

204 records · Page 12Linked to original sources
PubMedDate not supplied

Prostaglandin production and metabolism in self-differentiating human fetal lung organ culture.

PGE2 and PGF2 alpha are released into the media of human fetal lung organ cultures in decreasing amounts with time. This decline in PGs is not due to culture failure or loss of synthetic capacity, which can be stimulated by fetal bovine serum, nor is it due to increased catabolism of PGE2 to 13,14-dihydro-15-keto-PGE2 (PGEM) or of PGF2 alpha to 13,14-dihydro-15-keto-PGF2 alpha (PGFM). Immunohistochemically reactive PGs are not retained within lung cells. Antisera against methyl-moximated derivatives of PGEM or PGFM and preceded by derivatization on tissue sections of PGs by methyl-moximation not only demonstrate the localization of PGEM and PGFM in epithelial cells and blood vessels, but also show an overall decline in immunoreactivity with time. In addition electron microscopy of uncultured fetal lung removed directly after termination reveals various degrees of mitochondrial damage and in some cases plasma membrane blebs which resolve during the period in culture and as fetal lung self-differentiates. It is proposed that oxidative and mechanical stresses, occurring during termination of pregnancy or tissue preparation, result in cell damage and increased lung prostaglandin production, which, although decreasing during culture as cells recover, is sufficient to trigger terminal self-differentiation.

Cell Differentiation↗
PubMedDate not supplied

Oncology focus. Nursing patients with oral cancer.

Oral cancer is a particularly distressing disease, and treatment can be difficult to cope with. It is more common than is often realized, and may be preventable. This article discusses how nurses may help to reduce the incidence of advanced disease, and briefly explains how the treatment of intraoral cancer is managed in one specialised unit.

Adult↗
PubMedDate not supplied

Goings-on in a CCU: an ethnomethodological account of things that go on in a routine hand-over.

The transcripts of two hand-overs in a critical care unit are ethnomethodologically examined. Specimens of nurses' practices in accomplishing forms of social order are identified. The hand-overs show how nurses transfer all sorts of taken-for-granted scientific, technological, medical, nursing, psychological and sociological material. Doing routine work in nursing is shown to be accomplished, with relative ease, during the hand-over when what would otherwise be viewed as dramatic features, such as 'professional authority' and 'telling about dying', are routinely managed by these nurses.

Communication↗
PubMedDate not supplied

Computerized health information networks: house calls of the future?

The Cleveland Free-Net is the nation's first free open-access computer system providing health information to the public. An online survey was developed for the family medicine clinic housed within the Free-Net to study the characteristics of the users of the system and the reason they selected the Free-Net as a source of health information. Three areas were addressed: 1) user demographics; 2) content analysis of questions; and 3) reasons Free-Net was used instead of the person's own health care provider. An analysis of the initial system done in 1985 revealed that early users of the system were known to be predominantly white male professionals, generally in the 25-35 age range. In comparison to that profile, more of the users in this study were women, but the majority of users continued to be white male professionals. Questions asked can be classified in six categories: diagnosis, symptoms, treatment, medications, laboratory tests, and prevention. The main categories of medical concerns were cardiovascular, gastrointestinal, obstetrical, and gynecologic problems. Users tended to use the Free-Net for health information rather than their physician because the traditional means was not always appropriate for the life-style of this population.

Adult↗