Biomedical subjects

R Kawano

Publications and source records attributed to R Kawano.

10 recordsLinked to original sources

PubMed1989

The thallium-201 time activity curve in thyroid cancer: a role for the detection of metastases.

The Tl-201 Cl time activity curves were evaluated in 17 patients with histologically proven benign nodules and papillary carcinoma of the thyroid gland. In the dynamic studies, the uptake at the region of interest was counted every 10 sec for 20 min after the intravenous injection of 2mCi Tl-201 Cl. The curves from frame 21 to 100 were transformed to linear plots for clinical evaluation. Papillary carcinoma could not be differentiated from benign lesions by means of the values of the washout rate. However, the "relative washout rate" in papillary carcinoma was lower than that of benign lesions (P less than 0.05). Although the average values of the "relative extrapolated uptake" in papillary carcinoma appeared to be greater than those in benign lesions, the difference was not statistically significant. The difference in the washout rates between lymph node metastases and local recurrences, and pulmonary metastases of the papillary carcinoma was significant (P less than 0.05).

Adenoma↗

PubMed1987

Parathyroid adenoma imaged by gallium-67 citrate. A case report.

A parathyroid adenoma imaged by Ga-67 citrate in a 17-year-old man with primary hyperparathyroidism and a palpable solid tumor in the neck is presented. Although preoperative examination and intraoperative findings suggested a parathyroid carcinoma, histologic studies showed a parathyroid adenoma with predominant chief cell type.

Adenoma↗

PubMed1987

[A case of breast cancer with a chondrosarcomatous appearance].

A case of a breast tumor which showed the appearance of invasive ductal carcinoma and chondrosarcoma is reported. The patient was a 36-year-old female. Simple mastectomy and lymph node dissection were performed for the tumor. Local recurrence and metastases to the contralateral breast, lymph nodes, subcutaneous tissue, and bones arose after the operation. She died of the disease 2 years and 3 months after the operation. It is thought that this tumor had formed as a result of metaplasia of the carcinomatous tissue, since a histological transition between the carcinoma and sarcoma was demonstrated.

Adult↗

PubMed1986

Iodinated proteins in normal human thyroid gland. Thyroid albumin.

Iodinated proteins in normal thyroid tissue extracts were analyzed immunochemically, immunohistochemically and physicochemically after isoelectric focusing. An albumin-like protein ranging from pI 4.80 to 5.21 was found in normal human thyroid tissue extracts, and its pI range was not compatible with that of serum albumin ranging from pI 4.85 to 6.16. An immunodiffusion study suggests that T3 loosely combines with the albumin-like protein, and that this compound is so-called thyroid albumin. Amino acid analysis revealed a difference in the basic amino acid composition of thyroid albumin and serum albumin, and our immunohistochemical study showed that thyroid albumin and T3 were localized in follicular epithelial cells, but not in the colloid. Based on these results, thyroid albumin may be described as consisting of T3 and an albumin-like protein which is distinguishable from serum albumin and distinct from thyroglobulin immunochemically. It appears that a low molecular weight hormone like T3 can be detected when it combines with a protein molecule. Recently, DeGroot et al. (1975) suggested a collateral pathway of hormone metabolism through the thyroid albumin in thyroid follicular cells. Our results seem to support the existence of this pathway.

Albumins↗

PubMed1978