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Biomedical subjects

R Kashyap

Publications and source records attributed to R Kashyap.

113 records · Page 7Linked to original sources

Evaluation of daily dietary intake of dichloro-diphenyl-trichloroethane (DDT) and benzene hexachloride (BHC) in India.

Duplicate samples of the diet of vegetarian adults were analyzed to estimate the residues of dichloro-diphenyl-trichloroethane (DDT) and benzene hexachloride (BHC). The total food consumed by an adult per day was collected and categorized as fatty food, non-fatty food, water, and beverages. Fatty food was the main source of these chlorinated insecticides, and it contributed almost 50% of the total dietary intake. The average total DDT and BHC consumed by an adult were 19.24 micrograms/d and 77.15 micrograms/d, respectively. Blood DDT and BHC levels reflected intake (r = 0.685 for DDT; r = 0.515 for BHC).

Adult↗

Evaluation of human exposure to the persistent insecticides DDT and HCH in Ahmedabad, India.

Concentrations of two organochlorine insecticides, DDT and HCH, in 21 human adipose tissue samples (from cadavers) and 20 venous blood samples collected in Ahmedabad, India were determined. None of the cases had any history of occupational exposure to organochlorine insecticides. Residue concentrations of DDT and HCH in these samples indicated considerable exposure of the general population to these chemicals. Samples from males had comparatively higher concentrations of these insecticide residues than females. The mean residue concentrations of total DDT and HCH in the blood serum of males was 213.83 and 70.051 ppb, respectively, whereas females had DDT and HCH concentrations of 177.38 and 65.44 ppb, respectively. Total DDT and HCH in adipose tissue was 3.967 and 4.054 ppm in males, and 3.538 and 3.144 ppm in females, respectively. Residue concentrations reported here are lower than those reported earlier.

Adipose Tissue↗

A convenient method for the preparation of 99mTc-labelled pentavalent DMSA and its evaluation as a tumour imaging agent.

A cold kit has been developed for the instant preparation of 99mTc-(V)-DMSA. The radiochemical purity of the radiopharmaceutical was determined by chromatography. A study of the effect of pH and stannous chloride concentrations on its labelling efficiency demonstrated that pH 8.5-9.0 and 0.2 mg stannous chloride for 1.1 mg DMSA provides the optimum formulation (98%). The addition of ascorbic acid stabilized the kit for up to 24 weeks under refrigerated temperatures. The radiopharmaceutical was found to concentrate in the bone and muscles in contrast to trivalent DMSA which accumulates in the liver and kidneys in normal mice. Studies in patients have shown its usefulness in the scintigraphy of thyroid medullary carcinoma and in the brain metastasis of breast carcinoma.

Animals↗