Kidney function in experimental malaria.
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Kidney↗
Biomedical subjects
R KEELER
Publications and source records attributed to R KEELER.
The effects of loading rats with intravenous isotonic sodium chloride on the renal response to diuretics.
The effect of a number of diuretic agents was investigated on rats with different degrees of expansion of extracellular fluid volume. With moderate saline loading aminoisometradine and chlorthiazide were the most efficient diuretics. However, with a more severe saline load aminoisometradine and mersalyl had the greatest effect while chlorthiazide had no significant diuretic activity. The action of acetazolamide seemed independent of the saline load. Potassium chloride showed no diuretic activity. Injecting the drugs in pairs resulted in probable potentiation only with acetazolamide plus chlorthiazide. Since all the diuretics were used in doses which gave maximal effects, the summation of the effects of the other pairs of diuretics suggested different sites of action.
Acetazolamide↗
Effect of hypothalamic lesions on renal excretion of sodium.
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Hypothalamus↗
Investigation of mechanism of diuresis produced in the rat by an intravenous infusion of isotonic solution of sodium chloride.
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Animals↗