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Biomedical subjects

R K Wolf

Publications and source records attributed to R K Wolf.

33 records · Page 2Linked to original sources
PubMed1998

Early results of thoracoscopic internal mammary artery harvest using an ultrasonic scalpel.

OBJECTIVE: We developed a thoracoscopic internal mammary artery harvest technique using an ultrasonic scalpel, the Harmonic Scalpel (Ethicon Endo-Surgery, Cincinnati, OH). This is the first report of 9 month follow-up using this technique. METHODS: The Harmonic Scalpel is activated ultrasonically by vibrating at 55000 Hz. Compared with electrocautery, lower heat (<100 degrees C) and less smoke are generated. Thoracoscopic harvest using the Harmonic Scalpel with a hook blade was performed for 48 internal mammary arteries (42 left, six right) in 46 patients. Four (8.7%) of them were redo cases. The left internal mammary to left anterior descending artery and the right internal mammary to right coronary artery anastomoses were accomplished on the beating heart. Two left internal mammary arteries were sequentially, anastomosed to diagonal branches. Graft flow velocity was evaluated with pulsatile wave color Doppler test on the second or third postoperative day and repeated 3 and 6 months later. RESULTS: The mean harvest time was 65 min (range 35-95 min) for the left internal mammary artery and 37 min (range 25-45 min) for the right internal mammary artery. One left internal mammary artery was lost due to intimal dissection. The Harmonic Scalpel-related morbidity was transient left phrenic palsy in one case and mild heat injury at the skin incision in the majority of cases. One Patient (2.2%) expired due to ischemic bowel on the second postoperative day. At a mean of 9 months follow-up, 45 alive patients have been free of angina. Doppler studies revealed diastolic augmentation of the graft flow velocity in 22 left and two right internal mammary arteries on the second or third postoperative day and 23 left and five right internal mammary arteries 3 and 6 months after operation. CONCLUSIONS: Thoracoscopic internal mammary artery harvest is feasible and facilitated by the use of the Harmonic Scalpel. Early results of this technique are encouraging.

Coronary Disease↗
PubMed1998

[Video-assisted mammary harvest technique with harmonic scalpel].

We have developed a video-assisted mammary harvest technique using the Harmonic Scalpel. The clinical method and results are reported here. Since Nov. 1995, 70 left and 5 right internal mammary arteries (L/RIMAs) were taken down thoracoscopically and utilized for minimally invasive coronary artery bypass grafting. Each of the IMAs was harvested up to the upper margin of the first rib or higher and down to the bifurcation. Coagulation and cutting of the branches were achieved with excellent hemostasis using only the Harmonic Scalpel with a hook dissector. A CO2 insufflation technique with 8-10 mmHg of intrathoracic pressure safely improved visualization of the IMA in each case. The mean operative time was 65 minutes (range 45-95) for the left and 35 minutes (range 25-45) for the right. All the pedicled IMAs but one which was lost due to intimal dissection had satisfactory free flows. Video-assisted mammary harvest can be accomplished with insufflation technique and facilitated by using the Harmonic Scalpel with a hook dissector.

Coronary Artery Bypass↗
PubMed1997

Video-assisted thoracoscopic surgery (VATS). Endoscopic thoracoplasty technique.

STUDY DESIGN: The study of two patients whose rib deformity was treated using a new endoscopic thoracoplasty technique is reported. OBJECTIVES: To report a new endoscopic thoracoplasty technique for the treatment of rib deformities associated with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Thoracoplasty has traditionally been performed as an open procedure, often necessitating additional incisions and/or tissue dissection. METHODS: Two children with significant rib humps associated with idiopathic scoliosis were treated with a new endoscopic thoracoplasty technique. RESULTS: Both children showed dramatic cosmetic improvement of their rib deformity. CONCLUSIONS: The indications for the use of video-assisted thoracoscopic surgery in the treatment of pediatric spinal deformity are expanding. We have extended our video-assisted thoracoscopic surgery repertoire to include endoscopic thoracoplasty for treatment of rib deformities associated with idiopathic scoliosis. The technique for endoscopic thoracoplasty is discussed, and illustrative cases are presented.

Adolescent↗
PubMed1997

Thoracoscopic internal mammary artery harvest for MICABG using the Harmonic Scalpel.

BACKGROUND: Thoracoscopic internal mammary artery (IMA) harvest is technically demanding, particularly on the left side. We have devised a Harmonic Scalpel (Ethicon Endo-Surgery, Cincinnati, OH) technique to facilitate this procedure, and describe our clinical experience here. METHODS: The Harmonic Scalpel functions with ultrasonic energy, producing less smoke and lower heat than regular electrocautery. A total of 27 (22 left and 5 right) pedicles of the IMA in 23 patients were harvested from the upper margin of the first rib or higher to the lower margin of the fifth rib thoracoscopically using the Harmonic Scalpel with a hook blade. RESULTS: In each case, the IMA harvest was completed thoracoscopically with only the Harmonic Scalpel, decreasing instrument transfers. Each vascular branch was coagulated without charring and was transected with excellent hemostasis. Smokeless views were provided. In the first 17 harvests, Doppler studies 3 months after the procedures demonstrated patent IMAs to the coronary circulation. CONCLUSIONS: The Harmonic Scalpel facilitates thoracoscopic IMA harvest and is expected to minimize hyperthermic damage of the IMA.

Coronary Artery Bypass↗
PubMed1995

Coronary angioplasty to relieve a kinked venous bypass conduit.

An unusual case of kinking of a freshly placed venous bypass conduit was treated by PTCA and catheter traction. This provided translational movement of the conduit with loss of angulation, relief of kinking, and resumption of normal flow.

Angioplasty, Balloon, Coronary↗
PubMed1987

Transbrachial balloon catheter tamponade of ruptured abdominal aortic aneurysms without fluoroscopic control.

The advantages of the transbrachial intra-aortic balloon include preoperative control of hypotension with promptly improved coronary, cerebral, renal, lumbar and hepatic perfusion and control of blood pressure during the induction of anesthesia. The abdomen can then be entered without further hemodynamic decompensation. Careful dissection is facilitated by a drier field and palpation of the balloon in the aorta. These advantages were realized in this series of patients without delay in the operative procedure. The low incidence of organ failure in the three surviving patients, all of whom were in a high risk group, attest to the efficacy of the transbrachial balloon in correcting hypotension perioperatively.

Aged↗
PubMed1986

Transaxillary intra-aortic balloon tamponade in trauma.

A case of exsanguinating intra-abdominal hemorrhage from penetrating trauma in which hypotension was controlled with transaxillary intra-aortic balloon catheter tamponade is presented. Catheter placement without fluoroscopic control through a left brachial arteriotomy with local anesthetics used to control hypotension in exsanguinating abdominal trauma is discussed and compared with resuscitative thoracotomy and descending aortic occlusion in such patients. The efficacy and simplicity of balloon catheter tamponade for abdominal hemorrhage caused by trauma are emphasized.

Abdominal Injuries↗
PubMed1986

Celiac artery aneurysmectomy with pancreatectomy.

A case of symptomatic celiac artery aneurysm with pancreatic involvement treated by excision, 85% pancreatectomy, and direct reanastomosis of the common hepatic artery with restoration of arterial continuity is reported. This is the first reported case, of which we are aware, in which celiac artery aneurysm resection also required partial pancreatectomy. Pancreatic involvement by celiac artery aneurysm is discussed. The rationale for early diagnosis and recommended treatment is presented.

Aneurysm↗
PubMedDate not supplied

Efficacy and safety of constant-rate intravenous cyclosporine infusion immediately after heart transplantation.

Oral cyclosporine therapy immediately after heart transplantation is erratic and difficult to predict. The purpose of this study was to evaluate the relative efficacy and safety of cyclosporine when administered by constant-rate infusion immediately after transplantation. Nineteen patients (17 men and two women) aged 50 years (range 25 to 61 years) who weighed 71 +/- 9 kg, participated in the study and received cyclosporine, 7 to 10 mg/hr (117 +/- 15 micrograms/kg/hr). The infusions were initially maintained for 26 +/- 5 hours (range 18 to 42 hours) without adjustments in dosage. Whole blood samples were obtained at hourly intervals for the first 8 to 12 hours and then daily throughout the 7-day study period and were analyzed by high-performance liquid chromatography. Constant-rate cyclosporine infusion resulted in therapeutic blood levels (350 to 450 ng/ml) at 6 hours. These levels remained relatively steady throughout the 7-day infusion, requiring only minimal dosage adjustments. Kidney function was not altered significantly after 7 days of intravenous cyclosporine therapy as evidenced by a mean serum creatinine level of 1.3 mg/dl before therapy and 1.4 mg/dl after therapy. There, however, was a transient rise in serum creatinine level in most patients on the second or third day after transplantation that resolved without a reduction in cyclosporine dosage. The mean endomyocardial biopsy score at 1 week after transplantation was 0.1, and only four of the patients required additional immunosuppressive therapy to treat rejection during the first 6 weeks after transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Use of cyclosporine and ketoconazole without nephrotoxicity in two heart transplant recipients.

A cyclosporine-ketoconazole drug interaction was first described in 1981. It has been suggested that the two drugs should not be used concomitantly because of the danger of severe nephrotoxicity. Two reported cases indicate that cyclosporine and ketoconazole can be safely coadministered, provided that the dosage of cyclosporine is reduced appropriately. Two patients were initially given 8 mg/kg/day of cyclosporine at the time of heart transplantation, and the dosage was tapered to meet appropriate blood levels (250 to 350 ng/ml by whole blood high-performance liquid chromatography). During ketoconazole therapy (400 mg daily for 4 weeks), patient 1 received 80 to 100 mg/day of cyclosporine, which is equal to approximately 1 mg/kg/day, and patient 2 received between 40 and 80 mg/day of cyclosporine, which is equivalent to 0.4 to 0.8 mg/kg/day. Neither patient exhibited a creatinine value above 1.4 mg/dl while on combined therapy, and there were no problems with allograft rejection. Both patients had inappropriately high cyclosporine blood levels even with this marked reduction in dosage (patient 1, 520 to 1310 ng/ml and patient 2, 320 to 600 ng/ml). Thus it appears that cyclosporine and ketoconazole can be administered together safely, provided that there is an appropriate reduction in the dosage of cyclosporine; this results in the maintenance of adequate immunosuppression without development of nephrotoxicity.

Cyclosporins↗