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Biomedical subjects

R K Wadhwa

Publications and source records attributed to R K Wadhwa.

18 recordsLinked to original sources

Topical etidocaine during laparoscopic tubal occlusion for postoperative pain relief.

Narcotic requirements in 51 day-surgery patients following laparoscopic tubal occlusion were significantly reduced (P less than .01) by the use of 1% etidocaine 5 mL, dropped on each fallopian tube from uterus to fimbrias before tubal banding when compared with a control group of 51 day-surgery patients who had no topical anesthetic agent. All patients received general anesthesia. Although there was no significant difference in nausea rate, the incidence of vomiting was decreased. Eight of 51 patients (16%) having topical etidocaine and 19 of 51 (37%) who had no etidocaine vomited during the postoperative period. The frequency of overnight stay was significantly reduced in the topical etidocaine group of patients (P less than or equal to .01).

Acetanilides↗

Antiemetic effectiveness of intramuscular hydroxyzine compared with intramuscular droperidol.

In a double-blind randomized study 150 outpatients receivng the same anesthetic for first trimester therapeutic abortions were equally divided into three groups: control; droperidol, 2.5 mg IM; or hydroxyzine, 100 mg IM. The injection was given immediately after thiamylal (Surital) induction of anesthesia, and the incidence of nausea, retching, or vomiting (NRV) was recorded at 15-minute intervals for 3 hours after surgery. NRV occurred in 56% of control patients, in 44% of patients given droperidol, and in 10% of patients given hydroxyzine. The patients receiving hydroxyzine and droperidol were more sedated and experienced a delay in return of hand-eye coordination as measured by the time for the Trieger motor test to reach preoperative levels. All patients equaled their preoperative performance during the 3rd hour after surgery and were discharged 4 hours following general anesthesia. We conclude that intramuscular hydroxyzine hydrochloride, 100 mg, is a significantly better antiemetic than intramuscular droperidol, 2.5 mg.

Abortion, Induced↗

Noninvasive measurement of cardiac output during laparoscopy.

With the use of noninvasive transthoracic impedance cardiography we have demonstrated a consistent fall in stroke volume and cardiac output without significant clinical changes in heart rate in anesthetized patients undergoing laparoscopy. Cardiac output fell to a mean value of 60% in 14 patients undergoing laparoscopy and by a mean value of 6% in four patients undergoing laparotomy. The intraabdominal pressure did not exceed 20 torr in any laparoscopy patient. Some unexplained cardiac arrests during laparoscopy in healthy females may be caused by impaired venous return due to the increased intraabdominal pressure of pneumoperitoneum. Lethal values of cardiac output could result. The routine use of transthoracic impedance cardiography would alert the anesthesiologist to a dangerous situation that cannot be determined by current routine monitoring practice.

Abdomen↗

Anaesthesia for dilatation, evacuation and curettage in outpatients: comparison of subanaesthetic doses of ketamine and sodium methohexitone-nitrous oxide anaesthesia.

Sub-dissociative doses of ketamine compared unfavourably with methohexitonenitrous oxide anaesthesia for dilatation, evacuation and curettage. We could not separate the desirable effects of analgesia and amnesia from the unwanted dream effects and visual disturbances. Although the time of clinical recovery was similar, the Trieger Motor Test revealed a delay in return to normal in both groups.

Adolescent↗

Ketamine as the sole anaesthetic agent for laparoscopic sterilization. The effects of premedication on the frequency of adverse clinical reactions.

Ketamine, as the sole anaesthetic agent, was assessed in a double-blind study of 135 female patients who underwent laparoscopic sterilization. The patients were allocated randomly to one of four groups according to the type (pentobarbitone or droperidol) and route (i.v. or i.m.) of premedication. In addition all the patients received hyoscine i.m. Neither pentobarbitone nor droperidol prevented adverse emergence reactions and the total frequency of dream-like activity. However, patients who received pentobarbitone i.v. did not recall unpleasant dream-like activity. Patients who received droperidol i.v. had the shortest recovery time after ketamine anaesthesia. There was a high incidence of visual disturbances in all groups. Droperidol protected against the initial increase of heart rate, and pentobarbitone against the increase in arterial systolic pressure associated with ketamine.

Adult↗

Anesthesia for jejunoileal shunt: review of 88 cases.

Experience with 88 obese pateints undergoing jejunoileal shunt is reviewed, with emphasis on preoperative preparation and assessment, conduct of anesthesia, postoperative care, and anesthesia-related complications. There was no intraoperative mortality, and postoperative morbidity was minimal. The operation can be viewed as a short-term answer to the malignancy of massive obesity, since physiologic abnormalities are reversible; however, only hospitals that can provide full surgical, medical, endocrinologic, and anesthesia services, backed by modern ancillary investigative ability, should perform this operation.

Adult↗

Regional analgesia following epidural blood patch.

During the period November 1972 through October 1974, 118 epidural blood patch procedures were performed for severe postlumbar-puncture cephalgia. Subsequently, in a period varying from 105 to 380 days, three patients, two of whom had twice undergone epidural blood patch, were readmitted for either surgical operation or delivery. Either epidural, caudal, or spinal block was successfully accomplished. During the epidural block, the epidural block the epidural space was easily identified and no resistance was felt either to injection of the local anesthetic or to advancement of the epidural catheter. During the spinal block, ligmentum flavum was distinctly felt from the dura. The extent of the blocks, the onset and duration of action ofpivacaine, mepivacaine, and lidocaine were within normal limits. It is, therefore, concluded that epidural blood patch does not obliterate the epidural space and should not preclude the use of regional block for later surgical or obstetric procedures.

Adult↗