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Biomedical subjects

R K Menon

Publications and source records attributed to R K Menon.

76 records · Page 5Linked to original sources
PubMedDate not supplied

Diabetic pregnancy managed with intraperitoneal insulin.

A woman with insulin-dependent diabetes (IDDM) and resistance to subcutaneously injected insulin conceived while being treated with intraperitoneal (i.p.) insulin administered through a recently developed subcutaneous peritoneal access device (SPAD). She continued on this regimen during the pregnancy and at 37 weeks was delivered of a normal baby by Caesarian section. During her pregnancy, she had 2 episodes of infection of the SPAD, which were rapidly controlled by local instillation of antibiotics. Her diabetes remained under excellent control (HbA1: 7.3-7.5%) throughout her pregnancy. This case demonstrates that in such patients i.p. administration of insulin through a SPAD is a feasible mode of management during pregnancy.

Adult↗
PubMedDate not supplied

Insulin absorption accelerated by alpha-adrenergic blockade at injection site.

The effect of the addition of phenoxybenzamine to a regular insulin preparation on the absorption of insulin and plasma glucose concentrations was investigated in five normal subjects. The addition of phenoxybenzamine (20 micrograms) to insulin (0.2 U/kg body wt) resulted in an acceleration of insulin absorption, with a higher and earlier peak insulin concentration at 45 min and higher insulin concentrations throughout the 180 min of investigation. With phenoxybenzamine, plasma glucose concentrations fell more rapidly; nadirs were lower and more rapidly achieved. Two subjects experienced hypoglycemic symptoms when phenoxybenzamine was added to insulin. It is concluded that the addition of phenoxybenzamine to subcutaneously injected insulin increases the bioavailability of insulin for at least 3 h, which leads to a greater fall in plasma glucose concentrations.

Absorption↗