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Biomedical subjects

R K Jones

Publications and source records attributed to R K Jones.

At least 73 records · Page 4Linked to original sources
PubMed1975

Fluorescent antibody studies of alpha-1-antitrypsin in adult human lung.

The histologic distribution of alpha-1-antitrypsin in frozen sections prepared from four specimens of human lung was determined by the indirect fluorescent antibody technic. Three of the specimens were obtained directly from surgical procedures and were peripheral tissue excised with tumors. The tumors were a mixed-cell "scar cancer" (Case 1), a bronchiolar carcinoma (Case 2), and a benign hemartoma (Case 3). The fourth specimen (Case 4) was obtained at autopsy following death by myocardial infarction. Specific fluorescence for alpha-1-antitrypsin was observed lining the terminal airways and alveoli throughout the sections from Cases 1 and 4. In specimens from Cases 2 and 3, a few focal areas of specific fluorescence were observed. The results of this study suggest that alpha-1-antitrypsin may be distributed in lung in variable concentration in association with pulmonary surfactant.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1975

Comparative pulmonary carcinogenicity of inhaled beta-emitting radionuclides in beagle dogs.

Beta-emitting radionuclides are important constituents of isotope inventories in light water reactors and may pose an inhalation hazard to industrial workers or the general population if they are released. To study the biological effects of such potential exposures, a series of life span studies was initiated in which beagle dogs were exposed to aerosols of relatively insoluble fused clay particles containing 90Y, 91Y, 144Ce or 90Sr. Groups of dogs exposed to each radionuclide received graded initial lung burdens of radioactivity. When combined with the varied physical half-lives of the four radionuclides, this resulted in a wide variety of radiation doses and dose patterns to the lung. Deaths (greater than 640 days after exposure) were generally associated with pulmonary neoplasia in dogs that inhaled 91Y, 144Ce or 90Sr. These dogs had cumulative lung doses to death greater than 20 000 rads. Exposure to 144Ce or 90Sr with dose rates that decreased slowly induced pulmonary haemangiosarcomas. Pulmonary irradiation from 91Y, with a rapidly decreasing dose rate, resulted in pulmonary epithelial tumours. No malignant lung tumours have been seen within 1540 days after exposure to 90Y. The animals in the main studies have been observed for 1342 to 2756 days after exposure.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1974

Meralgia paresthetica as a cause of leg discomfort.

A series of 74 cases of meralgia paresthetica is presented. All patients were satisfactorily treated with nonsurgical modalities. A brief review of the etiological factors involved supports the impression that it is an entrapment syndrome related primarily to external pressure against the lateral femoral cutaneous nerve in the region of the anterior superior iliac spine. Though its peripheral symptomatology is relatively straightforward, often associated pain referred to the gluteal area results in an incorrect diagnosis of sciatic radiculopathy due to "disc disease". The correct diagnosis can be easily made from the relief obtained by injecting the lateral femoral cutaneous nerve with an anesthetic agent.

Chlorprothixene↗