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Biomedical subjects

R K Gupta

Publications and source records attributed to R K Gupta.

At least 793 records · Page 44Linked to original sources
PubMed1973

Loss of isoantigens A, B and H in prostate.

Formalin-fixed tissues from 65 prostates were grouped and investigated by the technic of mixed cell agglutination reaction (MCAR) for studying isoantigens A, B and H. The results of this study indicated that the MCAR was strongly positive at the epithelium of the acini in the majority of patients with benign prostatic hyperplasia. On the other hand, patients with primary carcinomas and metastatic carcinomas of prostates were found to be uniformly negative for any agglutination reaction. Prostates from a group of younger individuals only showed a patchy distribution of the MCAR at the epithelium of the acini. In view of these findings, it seemed that the traces of isoantigens in normal prostates show a considerable increase when the disease process of BPH becomes manifest in this organ, while in cases of primary and metastatic carcinomas the isoantigens are totally lost. In the light of previous studies on similar lines, the various possible mechanisms for this sudden transition are discussed.

Adenocarcinoma↗
PubMed1973

Immunohistochemical study of glomerular lesions in retroperitoneal lymphomas.

An immunohistochemical study was performed on the kidneys of 10 subjects with retroperitoneal lymphomas. Kidneys were first examined by light microscopy and six kidneys were further studied by immunofluorescence. Light microscopic evidence of damage found in 6 of 10 subjects was characterized by thickening of the basement membrane of glomerular capillaries and an increase in the mesangial matrix. In the areas of light microscopically visible damage, deposits of Schiff-positive material and argyrophilic material were present. No significant changes were found in the tubules. Four of the six kidneys which showed damage by light microscopy showed further evidence of histologic change in areas of glomerular damage when examined using the direct immunofluorescence technic. In 2 subjects, diffuse deposits of IgG and beta1C-beta1A globulin in basement membranes and the mesangial region were prominent, while in the remaining 2 subjects IgG and beta1C-beta1A globulin were localized as linear and/or beaded deposits, both inside and outside the basement membranes. Only focal deposits of these conjugates were seen in the mesangium. No localization of IgA, IgM, rabbit antihuman fibrin or fibrinogen was noted in any of the cases. The tubules yielded negative reactions for the localization of any of the conjugates. The results of this study seem to support the concept that, in some cases of retroperitoneal lymphomas, clinical and renal functional disturbances may be explained on the basis of an immunologic injury to the basement membranes of the glomeruli.

Basement Membrane↗
PubMed1973

Isoantigens A, B and H in benign and malignant lesions of breast.

Eighty-five specimens of breast tissue were grouped and investigated by the technic of mixed cell agglutination reation (MCAR) for studying isoantigens A, B and H (O). MCAR was found to be strongly positive at the epithelium of acini in all the 25 subjects with benign lesions (10 fibroadenomas, 10 cystic mastitis and 5 gynecomastias). On the other hand, all the subjects with diagnosis of primary carcinomas in breast (45 subjects) and their metastases (15 subjects) were found to be uniformly negative for any agglutination reaction. In view of these findings, it seemed that the isoantigens in primary and metastatic malignancies of breast are always lost, while in the benign lesions isoantigens are always present. Although the exact mechanism is not understood, it seems that, in malignancies with a glandular differentiation, some differences exist when these are compared to malignancies with a squamous differentiation. The various possibilities are discussed in the light of previous studies.

ABO Blood-Group System↗