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Biomedical subjects

R K Banerjee

Publications and source records attributed to R K Banerjee.

81 records · Page 5Linked to original sources
PubMed1977

Lack of effect of a granulocyte proliferation inhibitor or their committed precursor cells.

Using the agar culture technique, we have measured the effect of granulocyte extracts GCE (and of erythrocyte-RCE and lymph node extracts-LNE) on the growth and proliferation of the committed granulocytic precursor cells, CFU-C. In addition we have determined their effects on the proliferation of the developing colony cells and on the ultimate cell production in the colonies. The results show that GCE has no effect on the growth or proliferative activity on the CFU-C. It does, however, reduce both the autoradiographic labelling indices of the developing colony cells and the net colony cellularities, acting as a cell cycle modulator. These are effects specific to the GCE since at the dose levels used, neither RCE nor LNE affected these measurements.

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PubMedDate not supplied

Flow-pressure drop measurement and calculation in a tapered femoral artery of a dog.

This study describes the in vivo measurement of pressure drop and flow during the cardiac cycle in the femoral artery of a dog, and the computer simulation of the experiment based on the use of the measured flow, vessel dimensions and blood viscosity. In view of the experimental uncertainty in obtaining the accurate velocity profile at the wall region, the velocity pulse at the center was measured and numerical calculations were performed for the center line instantaneous velocity and within the two limits of spatial distribution of inlet flow conditions: uniform and parabolic. Temporal and spatial variations of flow parameters, i.e., velocity profile, shear rate, non-Newtonian viscosity, wall shear stress, and pressure drop were calculated. There existed both positive and negative shear rates during a pulse cycle, i.e., the arterial wall experiences zero shear three times during a cardiac cycle. For the parabolic inlet condition, the taper of the artery not only increased the magnitude of the positive and negative shear rates, but caused a steep gradient in shear rate, a phenomenon which in turn affects wall shear stress and pressure. In contrast, for the uniform inlet condition, the flow through the tapered artery was predominantly the developing type, which resulted in reduction in magnitude of wall shear rate along the axial direction.

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