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Biomedical subjects

R K Babu

Publications and source records attributed to R K Babu.

4 recordsLinked to original sources

A study of inpatient referral patterns to a general hospital psychiatry unit in India.

The pattern of inpatient referral to a general hospital psychiatry department was examined in the present study. The referral rate of 3.6% was higher than those reported by other investigators from India. The majority of the patients had concurrent physical illness. Neurotic depression and alcohol dependence were the most frequent diagnoses. A diagnosis of schizophrenia was relatively infrequent. Among the patients referred for consultation, there was a high percentage of cases of self-inflicted injury and poisoning. Psychiatric disturbances were of transient nature in about one third of the cases. In about 20% of the cases, no physical illness was detected and their somatic complaints were considered to be psychologically determined.

Humans↗

Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents.

We report here the synthesis of a series of 5-[4-[2-[substituted phthalazinones-2(or 4)yl]ethoxy]phenylmethyl]thiazolidine-2,4-diones and 5-[4-[2-[2,3-benzoxazine-4-one-2-yl]ethoxy]phenylmethyl]thiazolidine-2,4-diones and their plasma glucose and plasma triglyceride lowering activity in db/db mice. In vitro PPARgamma transactivation assay was performed in HEK 293T cells. In vitro and in vivo pharmacological studies showed that the phthalazinone analogue has better activity. PHT46 (compound 5a), the best compound in this series, showed better in vitro PPARgamma transactivation potential than troglitazone and pioglitazone. In insulin resistant db/db mice, PHT46 showed better plasma glucose and triglyceride lowering activity than the standard drugs. Pharmacokinetic study in Wistar rats showed good systemic exposure of PHT46. Subchronic toxicity study in Wistar rats did not show any treatment-related adverse effect.

Animals↗