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R Jung

Publications and source records attributed to R Jung.

140 records · Page 8Linked to original sources
PubMedDate not supplied

Age effects on interleukin-6 and interleukin-1beta responses to endurance exercise in patients with neuromuscular diseases.

Plasma IL-6 before and 20 min after prolonged muscular exercise for 20 min at the individual aerobic/anaerobic threshold was analyzed in patients with neuromuscular diseases and in controls. Patients were assigned to the following diagnostic categories: Controls (n=18); amyotrophic lateral sclerosis (n=7); peripheral neuropathy (n=6); muscular dystrophy (n=13); mitochondriopathy (n=3); myopathy (others) (n=3); inflammatory myopathy (n=6); mononeuropathy (n=4). The concentrations of IL-6 before exercise were 5.55+/-0.94 pg/ml, and 6.52+/-0.97 pg/ml after exercise (P=0.0001). We introduced the independent variables age, sex and diagnostic category into a stepwise multiple linear regression model. Age emerged as a significant predictor of the IL-6 ratio (IL-6 post exercise/lL-6 before exercise). The regression equation was: IL-6 ratio=0.87+0.009xage (years), R=0.33, P<0.01, simple linear regression model. All IL-1beta concentrations were below the sensitivity of the assay (5 pg/ml). Concerning patients with neuromuscular diseases, the age associated increased IL-6 release after exercise could mean additional muscle damage.

Journal Article↗
PubMedDate not supplied

[The prevalence of pain and deformities in the feet of adolescents. Results of a cross-sectional study].

AIM: The purpose of the study was to evaluate the prevalence of foot pain and foot deformities in adolescents. It was aimed to obtain information on the association between foot pain and foot deformities. METHOD: A total of 2 368 adolescents (age 14.5 +/- 0.7 years) were evaluated. The frequency of foot pain was probed by using a self-reporting questionnaire. The foot deformities were evaluated during clinical examinations by school doctors. RESULTS: The prevalence of foot pain was 14.0 % and the prevalence of foot deformities was 13.7 %. The prevalence of pain was significantly higher in adolescents with foot deformity (17.8 %) than in persons without deformity (13.4 %), p < 0.05. The prevalence of a flexible flat foot was 6.2 % and the prevalence of a rigid flat foot was 0.5 %. Other deformities registered were splay foot (2.3 %) and flexible splay-flat foot (2.0). The prevalence of hallux-valgus deformity was 3.5 %. A total of 3.5 % patients were suffering from a plantar hyperkeratosis. This was significantly correlated to a high pain prevalence (the hyperkeratosis was significantly associated with a high prevalence of pain). Significant factors which were significantly associated with foot pain were foot deformity (1.4 fold) and hyperkeratosis (75 fold). Foot pain was 1.4 fold higher in children with foot deformity and 75 fold higher in feet with hyperkeratosis. CONCLUSION: The prevalence of foot pain and foot deformity in adolescent is high. Mild deformities (flexible flat foot and splay foot) are physiological variations without any association to foot pain. Pathological conditions that are associated with foot pain are the rigid flat foot, the hallux valgus and the cavus deformity. Plantar hyperkeratosis is an indicator of foot pathology.

Adolescent↗
PubMedDate not supplied

[Coronary collateral circulation and prevention of ischemic mitral regurgitation].

INTRODUCTION: According to definition, collateral circulation is an alternative to major vascular flow which has become dysfunctional. Collateral channels, initially unused, are being formed due to impossibility of the main blood vessel to provide normal coronary flow. Recent controversies about collateral circulation are mainly based on their functional significance. The aim of this work was to evaluate the function of collateral circulation in patients after the first postero-inferior myocardial infarction i.e. whether adequate collateral circulation may reduce the size of myocardial infarction and prevent development of ischemic mitral regurgitation. MATERIAL AND METHODS: The investigation included 128 patients (pts) treated at the Institute of Cardiovascular Diseases in Sremska Kamenica during 1997 and 1998. The investigation group (I) included 64 pts, 58 males and 6 females, mean age 54.42 years. The control group (C) included 64 pts, 56 males and 8 females mean age 51.71 years. In all patients the first posterior, inferior and postero-inferior myocardial infarction were proven during 1-year period. Cineventriculography confirmed kinetic disturbance of the area with or without mitral insufficiency. Degree of mitral regurgitation was evaluated according to Seller's criterion. Alterations on the right coronary or circumflex branch of the left coronary artery were confirmed, but significant stenotic alterations were not verified on the anterior descendent branch of the left coronary artery. Alterations on epicardiac coronary vessels were presented as total coronary score--modification according to Benc (18 segments) while numerical values for stenosis according to Kaltenbach. This value represents the total coronary score (SCORE-A) including alterations before and after occlusion. Gensiny's principle modified for multiplication factor according to Benc and numerical value according to Kaltenbach were used for evaluation of collateral circulation. Levin's classification was used for evaluation of collateral circulation quality. We used quantitative classification according to Cohen. RESULTS: Distribution of mitral regurgitation was not statistically and significantly frequent in the subgroup of patients with lesions on the right coronary artery in relation to subgroup of patients with combined lesions on the right coronary artery and circumflex branch of the left coronary artery (p > 0.05). None of the investigated patients with extensive lesions (lesions on ACD and RCX) had mitral regurgitation of IV degree, so the number of investigated patients was not adequate for statistical evaluation. We did not find a statistically significant difference in the percentage of collateral circulation between the investigation (59.4%) and control group (62.5%) (p > 0.05). Poorly developed collaterals were statistically and significantly more frequent in the investigation group (60.5%) in relation to control group (10%) (p < 0.01). The percentage of moderately developed collateral circulation was similar in both groups. Well developed collateral circulation was statistically and significantly more frequent in control group (52.5%) in relation to investigation group (7.9%) (p < 0.01). The extension of stenotic alterations expressed as total coronary score A was statistically and significantly higher in subgroups of investigated patients with combined alterations on ACD and RCx, proving the sensitivity of our score system in smaller extensity of stenotic lesions on epicardial coronary blood vessels. Collateral circulation was significantly better in patients with ACD occlusion (100%) in relation to patients with significant stenosis or ACD subocclusion (33.3%) (p < 0.01). DISCUSSION: The functional role of collaterals has not been explained yet. The efficacy of coronary collateral vessels and mechanism of adequate compensation of regional perfusion in a position distal from the occluded vessel is highly controversial. (ABSTRACT TRUNCATED)

Collateral Circulation↗
PubMedDate not supplied

Dominant hemodynamic parameters of chronic ischemic mitral regurgitation.

The study included 128 patients treated at the Institute of Cardiovascular Diseases in Sremska Kamenica within a year after the first posteroinferior myocardial infarction. On the basis of hemodynamic measurements, patients were divided into 2 groups. Group I (examinees) included 64 patients (58 males and 6 females, mean age 54.42 +/- 6.70 years) with proven mitral regurgitation and group 2 (control) included 64 patients (56 males and 8 females, mean age 51.71 +/- 8.84 years) without mitral regurgitation, but with stenotic changes in the right coronary artery and left circumflex coronary artery without significant stenotic lesions at the anterior descending left coronary artery. According to Sellers classification mitral regurgitation in group I was as follows: I grade 37.5%, II grade 31.3%, III grade 21.9% and IV grade 9.3%. Measured hemodynamic parameters in basal conditions (systolic, diastolic and mean pulmonary pressure, capillary pulmonary pressure and wave V, left ventricular end-diastolic pressure) point to significant impairment of diastolic function in group I apart from similar values of systolic function (cardiac output, cardiac index and ejection fraction). Dimension of the left atrium and left ventricle determined by transthoracic echocardiography confirm this. There was a positive correlation of examined parameters (pulmonary capillary and total pulmonary resistance) and the degree of mitral regurgitation, as well as the correlation between the degree of mitral regurgitation and hemodynamic parameters. It may be concluded that postinfarction mitral regurgitation in examined patients is of II degree on the average; total and capillary pulmonary resistance are most sensitive hemodynamic parameters for examining the severity of mitral regurgitation, whereas the size of the left atrium is the most sensitive echocardiographic parameter.

Chronic Disease↗
PubMedDate not supplied

[The first non-Q myocardial infarct as a clinical manifestationn of acute coronary syndrome].

INTRODUCTION: Non-Q myocardial infarction is only one of the possible clinical manifestations of acute coronary syndromes. Acute coronary syndrome is the most frequent cause of hospitalization in everyday cardiological practice. OBJECTIVES: 1. To evaluate the incidence of unstable angina and myocardial infarction in the group of patients admitted to hospital with diagnosis of acute coronary syndromes; 2. To evaluate the incidence of non-Q myocardial infarction in the group with index myocardial infarction; 3. To determine the frequency of different ECG changes in the subgroup with non-Q myocardial infarction. MATERIAL AND METHODS: The study was conducted at the Institute of Cardiovascular Diseases in Sremska Kamenica in the period between Jan. 1, 1997 and Dec. 31, 1999. Hospitalized patients with acute coronary syndromes (n = 3.337) were divided into subgroups with unstable angina (chest pain, ECG changes and normal level of CK) and with myocardial infarction (chest pain, ECG with/without changes, elevation of cardiac enzymes). Myocardial infarction without Q waves on ECG was considered to be non-Q myocardial infarction. Initial ECG changes (ST elevation, ST depression, inverted T waves, abscence of changes) were evaluated in patients with non-Q myocardial infarction who were not treated with Streptase. RESULTS: During a three-year period, 3.337 patients with acute coronary syndrome were hospitalized. 65.3% of them had unstable angina, while 34.7% suffered from myocardial infarction. In the group with myocardial infarction, 12.9% (280/2179) had reinfarction. 8.8% of patients were treated with thrombolytic agents, which prevented formation of Q waves in 24.6% of patients. In the group of patients who were not treated with thrombolytics, 196 patients (11.8%) fulfilled criteria for non-Q myocardial infarction. Incidence of initial ST elevation, ST depression and inverted T waves in those patients with non-Q myocardial infarction were 11.2%, 35.2% and 52.1% respectively, whereas 1.5% had no ECG changes. CONCLUSION: Both incidence of unstable angina and non-Q myocardial infarction, as manifestations of acute coronary syndromes, and incidence of newly formed ST elevation, which is one of the forms of initial ECG changes in non-Q myocardial infarction, are significantly lower than those found in literature.

Angina, Unstable↗