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Biomedical subjects

R Jovanović

Publications and source records attributed to R Jovanović.

At least 19 recordsLinked to original sources
PubMed2001

Gastrointestinal malignant lymphomas in Macedonia.

The gastrointestinal tract including oral cavity is the most common location of extranodal lymphomas. In this retrospective study, the histomorphological, immunohistochemical and clinical features of 21 Macedonian cases with diagnosed malignant lymphomas were investigated. The series included 15 males and 6 females, mean age 44 (4-78) years. The most common locations were hard palate (n = 7), gastric site (n = 5), small intestinal wall (n = 2), large intestinal wall (n = 5), and lingual root (n = 2). All cases were B cell lymphomas, 23.8% of them low grade B cell lymphoma of mucosa associated lymphoid tissue, 4.7% mantle cell lymphoma, 47.6% diffuse large cell lymphoma, and 23.8% Burkitt type lymphoma. There was no T cell lymphoma. Most of the cases were positive for CD20 and CD79a. Monoclonality was confirmed by light chain restriction, except for nine cases where it failed due to poor tissue preservation. The fact that eight cases were in the clinically advanced third and fourth stage implied a conclusion that not only primary non-Hodgkin's lymphomas but also secondary lesions could invade the gastrointestinal tract. Immunohistochemical staining was helpful in differentiation between benign and malignant infiltration in low grade lymphomas, and in distinguishing diffuse large cell lymphomas from undifferentiated epithelial neoplasms.

Adolescent↗
PubMed1996

[Use and preparation of thrombocyte concentrates].

Blood component transfusion therapy is an achievement of up-to-date transfusiology and is possible due to plastic equipment, centrifuge with air conditioning and modern technology which enables splitting blood into its components. Platelet concentration is a preparation of platelets gained from one unit of the whole blood and is used in therapy of patients with thrombocytopenias and thrombocytopathies. It can be preserved, depending on plastic bags, from 1 to 5 days with rotation on 22 degrees Celsius. This paper presents two methods of platelet concentration preparation (out of thrombocytes rich plasma and buffy coat) contribution of thrombocytes in concentrations and contamination of concentration with leucocytes, as well as changes during 72 hours of concentration preservation. One hundred units of thrombocytes had an average volume 51.42 ml. Platelet concentration gained out of thrombocyte rich plasma was 0.98 x 1011/l, and 0.80 x 109/l leucocytes. The number of thrombocytes in concentrations from buffy coat was 0.82 x 101/l, and 0.10 x 109/l leucocytes. Plasma pH after preparation was 7.21, and three days of conservation later it was 6.68. During these 72 hours of preserving the concentration there has not been a significant decrease in regard to the number of thrombocytes.

Humans↗
PubMed1996

[Transfusion aspects of viral hepatitis C].

The investigation comprised 83 patients with acute non-A, non-B hepatitis who were treated at the Clinic of Infectious and Dermatovenerology Diseases in Novi Sad in the period 1986-1991. They were receiving blood transfusions and/or blood products from blood donors who had not been previously tested for presence of hepatitis C virus (HCV). In order to establish diagnosis anti-HCV ELISA screening tests from various producers were used. Out of 83 blood screening assays 17 patients (20.48%) were found to be anti-HCV seropositive. Out of these 17 seropositive patients 3 patients were intravenous drug-addicts (IVDA), while 14 patients (16.68%) previously received blood transfusions, whereas out of these 7 patients underwent open heart surgery. Only 2 blood donors, out of 48 whose blood was used for therapeutical purposes, were found to have anti-HCV antibodies after blood screening assays. The blood with detected anti-HCV antibodies caused acute post transfusion hepatitis C in 6 blood recipients. The obtained results show that comprehensive and thorough blood screening assays should be performed in all blood donors in order to prevent incidence of post transfusion C hepatitis. The Blood Transfusion Center in Novi Sad introduced compulsory viral screening assays for all blood donors on November 15, 1994, and since then 15019 blood donors have been tested. Only 38 (0.25%) were found to be anti-HCV seropositive, and were excluded from further blood donation and are under constant control. Now it is impossible to transmit HCV to patients who receive blood transfusion and/or blood products, and at the same time anti-HCV seropositive donors are prevented to develop chronic hepatitis and adverse complications due to HCV presence.

Adolescent↗
PubMed1993

[Lyme disease and pregnancy].

The authors have investigated Borrelia infection in pregnant women with two or more spontaneous abortions, but with no clinical manifestations of Lyme disease. In 42 such cases the results were negative. On the other hand, in two cases with positive epidemiologic data, but without clinical manifestations of Lyme disease, serologic findings were positive. No complications during pregnancy or after childbirth were recorded.

Adult↗
PubMed1988

Recovery from herpes simplex virus type-1 hepatitis in a female adult.

A study of one case of herpes simplex hepatitis in an adult woman is presented. The clinical feature and laboratory findings were typical for acute hepatitis in a febrile patient without herpetic mucocutaneous lesions. The evidence of high IgM antibody titer in serum against herpes simplex virus and confirmation of the herpes simplex virus hepatitis by immunofluorescent microscopy after liver biopsy helped us establish the diagnosis. After 3-months the patient recovered.

Adult↗
PubMed1977

[Role of the partogram in the modern conduction of labor].

The authors present an original partogram showing the course of labour. The partogram consists of three parts. Its back first contains columns for general data, the position of the fetus, the results of amnioscopy and prepartal cardiotocography with the oxytocin test. The second part contains data on the progressed dilatation of the uterine cervix, the condition of the bag of waters, the quality of the amnionic fluid, uterine contractions, and he results of the pH-metry and the interpretation of cardiotocography in the course of labour. The third part contains the diagnosis of delivery and the newborn's vital symptoms. Six partograms of women with different characteristics and different pathologic conditions are presented. The authors underline the simple way of composing and using the partogram, as well as the benefit deriving from it, especially when several labours are conducted at the same time.

Adult↗