[Anaplastic small cell bronchus carcinoma. Diagnosis, treatment and prognosis].
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Carcinoma, Small Cell↗
Biomedical subjects
R Joss
Publications and source records attributed to R Joss.
[Malignant melanoma: spontaneous course, therapy and prognosis].
The natural history, treatment and prognosis of malignant melanoma are reviewed. Stage, histologic level of invasion and clinical type are the most important prognostic factors. Surgical approach for treatment of the primary tumor, adjuvant therapy and treatment of advanced disease (chemotherapy, hormonal manipulation and immunotherapy) are discussed. 5-year survival rates are tabulated in relation to the most important prognostic factors.
Female↗
[Kidney and urinary tract complications in tumor patients].
This review deals with renal and urinary tract complications in tumor patients. Neoplastic infiltration of the kidney and glomerular nephropathies in neoplastic diseases are discussed. Tumor obstruction of the urinary tract and renal disease due to tumor metabolites are important, potentially reversible complications. Radiation nephritis and drug-induced renal disease can often be avoided with the aid of precautionary measures. Urogenital infections in tumor patients are frequent and often due to atypical microorganisms. Guidelines for dosage modifications of antineoplastic agents in patients with renal insufficiency are summarized. Renal failure in tumor patients deserves a careful diagnostic and therapeutic approach. The potential renal and urinary tract toxicities of the different therapeutic modalities must be considered when planning therapy for cancer patients.
Alkylating Agents↗
[Pregnancy following tumor therapy].
A report is presented on 9 patients who became pregnant and gave birth to 11 children after intensive or long-term tumor therapy. Eight patients had Hodgkin's disease and one patient metastatic choriocarcinoma. Two children had a birth defect probably related to the anticancer therapy: one child has hearing loss of the inner ear and one child a cleft lip and palate. Some general issues relating to pregnancy after tumor therapy are discussed.
Abnormalities, Drug-Induced↗
Collagen type III induced ex vivo thrombogenesis in humans. Role of platelets and leukocytes in deposition of fibrin.
Exposure of type III collagen coats on plastic cover slips in parallel-plate perfusion chambers to flowing nonanticoagulated human blood resulted in deposition of platelets and fibrin. Blood was drawn directly from an antecubital vein by an occlusive roller pump over the collagen coats in chambers having flow slits of different dimensions, so that wall shear rates of 100, 650, and 2600 s-1 were obtained at 10 ml/min. Coagulation was minimally activated during the passage of blood from the vein to the chamber as shown by fibrinopeptide A levels of 3.7 ng/ml after 5-minute perfusions. The surface coverage with platelets increased from 18% at 100 s-1 to 59% at 2600 s-1, and the corresponding thrombus volumes increased from 2 to 22 microns 3/microns 2, respectively. This contrasted with the coverage with fibrin on collagen, which decreased from 28% at 100 s-1 to 9% at 2600 s-1. Fibrin deposits on the thrombi covered 6% of the surface irrespective of the shear rate, indicating that some of the deposited platelets accelerated the deposition of fibrin. The type III collagen preparation did not activate factor XII and did not possess tissue factor activity, indicating that the surface itself was not procoagulant. However, a correlation between deposited leukocytes and surface coverage with fibrin was observed (r = 0.78, p less than 0.01), suggesting a role for these cells in the deposition of fibrin. The data demonstrate that thrombogenesis is triggered by pure type III collagen, although the deposition of fibrin is not initiated by the collagen itself but presumably by deposited leukocytes.(ABSTRACT TRUNCATED AT 250 WORDS)
Blood Coagulation↗