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Biomedical subjects

R Jones

Publications and source records attributed to R Jones.

At least 613 records · Page 34Linked to original sources
PubMed1992

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Abstracting and Indexing↗
PubMed1992

Advance directives.

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Advance Directives↗
PubMed1992

Should private payers adopt RBRVS fee schedules?

Independent Blue Cross and Blue Shield plans are adopting RBRVS-based fee schedules for reimbursing physicians. Some argue that private payers should follow suit.

Blue Cross Blue Shield Insurance Plans↗
PubMed1992

Dyspepsia in the community: a follow-up study.

We have repeated a population-based survey of the pattern and prevalence of dyspeptic symptoms in 2460 subjects two years after the original survey, in order to document the changes in dyspeptic symptoms and consultation behaviour. A validated postal questionnaire was sent to 2460 subjects randomly selected in ten-year age bands from the lists of eight general practitioners working in the south of England. A total of 1417 individuals (58%) responded to both questionnaires. The overall six month prevalence of dyspepsia was unchanged (38%), but while 74% of dyspeptic patients were still getting symptoms, 13% became symptom-free each year. Over half of those who had reported dyspepsia before, but not at the time of, the first survey had experienced recurrence of their symptoms. In the two-year study period 113 individuals experienced dyspepsia for the first time, giving an annual incidence of 11.5%. One in four patients consulted their general practitioner, and 75% of those who had not consulted in the first survey still had not done so two years later. Resolution of symptoms appeared independent of consulting behaviour. Peptic ulcers were identified in 14 patients, mostly those with new dyspepsia, during the study period.

Adult↗
PubMed1992

Effect of radiation dose on the development of mixed haemopoietic chimerism following T cell-depleted allogeneic bone marrow transplantation.

The presence of mixed haemopoietic chimerism (MXC) was evaluated by cytogenetic and molecular analysis in 48 patients undergoing T cell-depleted BMT. The dose of total body irradiation (TBI) prescribed to all patients (14.4 Gy) was calculated to compensate for the absence of T cells in the graft. The actual midline dose of TBI received, however, differed significantly depending on the method of TBI administration. Thus, 35 adult patients received an average midline dose of 14.3 Gy, while 13 children received a lower dose of 13 Gy. The incidence of MXC in the adult group, who had received very close to 14.4 Gy to the midline, was 34% (12/35), which is lower than in most reported T cell-depleted series. During follow-up, chimerism remained relatively stable with time but varied between haemopoietic lineages. There was no relationship with relapse. MXC in the 13 children who had received a lower midline TBI dose was significantly higher at 69% (9/13) (p < 0.05) and increased to 90% (9/10) if patients who received additional chemotherapy in their conditioning were excluded (p = 0.001). This suggests that, in terms of marrow ablation, relatively small changes in the dose of TBI may be biologically significant, at least at this dose range. Again, in the lower TBI group MXC was not predictive of relapse.

Adolescent↗
PubMed1992

Ultrastructural analysis of contractile cell development in lung microvessels in hyperoxic pulmonary hypertension. Fibroblasts and intermediate cells selectively reorganize nonmuscular segments.

The current study traces the development of contractile cells in the nonmuscular segments of rat lung microvessels in hyperoxic pulmonary hypertension. New intimal cells first develop into a well-defined layer beneath the endothelium and internal to an elastic lamina. Ultrastructurally, these cells are found to be 1) fibroblasts recruited to the vessel wall from the interstitium and 2) intermediate cells, a population of preexisting vascular cells (structurally between a smooth muscle cell and a pericyte). Early in hyperoxia (days 3 through 7), interstitial fibroblasts migrate and align around the smallest vessels in which an elastic lamina is either absent or fragmentary. These cells then are incorporated into the vessel wall by tropoelastin secretion and the formation of an elastic lamina along their abluminal margin. After day 7, the new mural fibroblasts acquire the features of contractile cells, namely a basal lamina, extensive microfilaments, and dense bodies. In other vessels, as early as day 3 of hyperoxia, intermediate cells within the vessel intima begin to acquire the additional filaments and dense bodies of contractile cells. As hyperoxia continues, each cell pathway gives rise to vessels with distinct intimal or medial layers of contractile cells. In this way, thick-walled 'newly muscularized' vessel segments form adjacent to the capillary bed.

Actin Cytoskeleton↗
PubMed1992

Reasons for consultation in irritable bowel syndrome: symptoms and patient characteristics.

This study compared the characteristics of patients with symptoms of irritable bowel syndrome who had either consulted or not consulted a general practitioner in the preceding two years. The subjects were identified by questionnaire in a community survey of irritable bowel syndrome symptoms and samples of 24 consulting and 24 non-consulting patients were interviewed. The groups were well matched for demographic characteristics, although those who consulted for irritable bowel syndrome also consulted more frequently for other problems. The only significant differences in the pattern, frequency and severity of a range of symptoms, which included the Manning criteria, were that more of the consulting patients experienced visible abdominal distension and had a higher mean score for severity of pain than the non-consulters. Mean negative life event scores and anxiety and depression scores were higher in the group who consulted and more of these patients were concerned about the possible serious nature of their symptoms, including fear of cancer, emphasizing the importance of eliciting patients' beliefs and anxieties about the meaning of their symptoms.

Adult↗
PubMed1991

A 23 kDa protein from rat sperm plasma membranes shows sequence similarity and phospholipid binding properties to a bovine brain cytosolic protein.

A 23 kDa protein that is a major component of rat epididymal secretions and sperm plasma membranes has been purified and partially sequenced. A data-base search revealed approximately 85% sequence similarity with a phosphatidyl-ethanolamine-binding protein from bovine brain cytosol. The rat 23 kDa protein also showed selective affinity for phosphatidylethanolamine (Kd = 1.6 x 10(-5) M) with lower activity towards phosphatidylinositol and phosphatidylcholine. It is suggested that differential affinity of protein antigens towards asymmetrically aligned phospholipids in sperm plasma membranes could account for their organisation into specific regional domains.

Amino Acid Sequence↗