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R Jin

Publications and source records attributed to R Jin.

113 records · Page 7Linked to original sources
PubMedDate not supplied

Second surgical treatment of retroperitoneal persistent disease in epithelial ovarian cancer.

AIMS AND BACKGROUND: This report retrospectively analyzes 9 cases of epithelial ovarian cancer with persistent retroperitoneal metastasis after intraperitoneal surgery (without systematic lymphadenectomy) and chemotherapy. METHODS: All 9 patients were diagnosed as FIGO stage I to IV at the time of primary surgery. They received combined postoperative chemotherapy (8 cases with a cisplatin-based regimen and 1 with adriamycin and endoxan). They were submitted to pelvic and paraaortic lymphadenectomy at the National Cancer Institute of Milan during the period 1990-1994. RESULTS: All patients presented no evidence of disease in the abdominal cavity but retroperitoneal metastasis, which was the unique metastatic site. Chemotherapy was administered as adjuvant therapy after lymphadenectomy. Six patients were free of disease for 14 to 61 months. One patient with vaginal recurrence at the 18th month was treated with radiotherapy and chemotherapy, but died of widespread disease 25 months after lymphadenectomy. Two patients with massive positive lymph nodes dies of brain and lung metastasis 20 and 6 months later, respectively. CONCLUSIONS: We conclude that retroperitoneal metastasis may be the only site of persistent disease and that systematic lymphadenectomy technically feasible in this situation to increase the opportunity for local disease control and to obtain a good result.

Adult↗
PubMedDate not supplied

Malignant rhabdoid tumor of the vulva: a case report and review of the literature.

Malignant rhabdoid tumor (MRT) is an uncommon aggressive neoplasm which usually occurs in the kidney of children, but it has also been found in extrarenal sites. MRT arising in the vulva is extremely rare. Only four cases of MRT of the vulva have been reported in the English literature. We herein present another case. The diagnosis and management of vulva MRT are reviewed.

Adult↗
PubMedDate not supplied

Metallothionein expression and zinc levels in invasive ductal breast carcinoma.

Metallothioneins (MTs) and zinc are both known to promote progression of tumors in human cancers. A close relationship exists between MT and zinc, as synthesis of the former has been reported to be induced by the latter. To assess the relationship between MT and zinc content in breast cancer tissues, we analysed MT expression by immunohistochemistry and tissue zinc levels by atomic absorption spectrometry (AAS) in invasive ductal breast cancers and adjacent benign breast tissues. We observed overexpression of MT in breast cancer tissues and noted that zinc content in breast cancer tissues was twice that of benign breast tissues. The nuclear fraction obtained by subcellular fractionation of breast cancer tissues was found to have a higher zinc content than the plasma membrane and cytosolic fractions. Contrary to expectations, we found a significant inverse correlation of MT expression with zinc levels in breast cancer tissues, suggesting that whilst both synergistically influence growth and survival of tumor cells, they may also have divergent roles in carcinogenesis.

Breast↗
PubMedDate not supplied

Modulation of the rat tumor-associated shedding antigen (CE7) and augmentation of immunogenicity by irradiation.

We have previously reported that rat fibrosarcoma KMT-17 cells and their in vitro counterparts, cloned A3 cells, shed a tumor-associated antigen (TAA), termed CE7, from the cell surface on vesicular membranes, under growth-enhancing conditions. This study shows that irradiation (1 approximately Gy) from a 60Co source, inhibited A3 cell growth dose-dependently and correspondingly increased CE7 expression by A3 cells as determined by anti-CE7 monoclonal antibody using flow cytometry. CE7 expression gradually increased with increasing doses of irradiation and reached a peak level at 30Gy. After 30Gy irradiation, CE7 expressing A3 cells were fixed with 1% paraformaldehyde and were used to intradermally immunize syngenic rats. Immunized rats developed transplantation resistance to the parent KMT-17 cells as compared to rats immunized with unirradiated A3 cells. Rat MHC class 1 antigen expression was slightly decreased by irradiation and therefore, resistance to tumor transplantation appeared to arise solely due to the enhancing effects of irradiation on TAA expression which increases the antigenicity of the tumor cells coverting them to an effective stimulator of antitumor effector cells. This phenomenon may offer a possibility of the resistance to the re-emergence and metastasis of the tumor like a KMT-17 through the induction of antitumor memory cells.

Animals↗